Patents by Inventor Hideo Iba
Hideo Iba has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11479769Abstract: Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a delivery system for delivering such an miRNA inhibitory complex.Type: GrantFiled: March 16, 2018Date of Patent: October 25, 2022Assignees: National University Corporation Chiba University, GeneDesign, Inc., NOF CorporationInventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
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Patent number: 11285168Abstract: Tumor growth was found to be significantly suppressed in vivo by inhibiting both miRNA containing 5?-AACACUG-3? as a seed sequence and miRNA containing 5?-AAUACUG-3? as a seed sequence. The inhibition significantly altered the proportion of subpopulations of tumor cells and reduced the tumorigenicity in all subpopulations. The inhibition also exerted a remarkable tumor-shrinking effect on already-formed tumors. The present invention provides novel therapeutic potential against tumor.Type: GrantFiled: September 27, 2016Date of Patent: March 29, 2022Assignee: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITYInventors: Hideo Iba, Takeshi Haraguchi
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Patent number: 10844376Abstract: The present invention pertains to the improvement of a miRNA inhibitor (a synthesized Tough Decoy (S-TuD)). The present invention provides a miRNA inhibitory complex including RNA or an analog thereof, wherein the RNA inhibitory complex includes at least one double-stranded structure and a miRNA binding sequence, each of two strands of the miRNA binding sequence being bound to two strands of at least one end of the double-stranded structure, and the miRNA inhibitory complex further includes at least one crosslinked nucleic acid.Type: GrantFiled: September 16, 2016Date of Patent: November 24, 2020Assignees: University of Tokyo, GeneDesign, Inc.Inventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
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Publication number: 20200147120Abstract: The present invention provides an anticancer agent based on a novel mechanism. Specifically, the present invention relates to an inhibitor that inhibits gene expression regulation by SWI/SNF complex-dependent NF-?B or a corepressor complex that participate in chromatin remodeling. More specifically, the present invention provides an inhibitor that reduces the interaction (such as binding and transcription regulation) of endogenous SWI/SNF complexes with NF-?B or a corepressor complex, or an inhibitor that inhibits the adapter function of d4 family proteins. The inhibitor of the present invention can be utilized in the treatment of cancers involving SWI/SNF complexes (such as SWI/SNF-mediated cancers).Type: ApplicationFiled: February 16, 2018Publication date: May 14, 2020Inventors: Hideo IBA, Kazuyoshi KOBAYASHI
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Publication number: 20200032262Abstract: Provided is a novel technique for treating cancer using structurally-reinforced S-TuD. Provided are: a composition for the prevention or treatment of tumors, said composition comprising an miRNA inhibitory complex including RNA of analog thereof; and a method for preventing or treating tumors using said composition. The miRNA inhibitory complex preferably includes at least one double-stranded structure and an miRNA-binding sequence. Two strands of the miRNA binding sequence preferably bind individually to two strands on at least one end of the double-stranded structure. According to some of the aspects of the present invention, there is provided a delivery system for delivering such an miRNA inhibitory complex.Type: ApplicationFiled: March 16, 2018Publication date: January 30, 2020Inventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
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Publication number: 20180271895Abstract: Tumor growth was found to be significantly suppressed in vivo by inhibiting both miRNA containing 5?-AACACUG-3? as a seed sequence and miRNA containing 5?-AAUACUG-3? as a seed sequence. The inhibition significantly altered the proportion of subpopulations of tumor cells and reduced the tumorigenicity in all subpopulations. The inhibition also exerted a remarkable tumor-shrinking effect on already-formed tumors. The present invention provides novel therapeutic potential against tumor.Type: ApplicationFiled: September 27, 2016Publication date: September 27, 2018Applicant: NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITYInventors: Hideo IBA, Takeshi HARAGUCHI
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Publication number: 20180223281Abstract: The present invention pertains to the improvement of a miRNA inhibitor (a synthesized Tough Decoy (S-TuD)). The present invention provides a miRNA inhibitory complex including RNA or an analog thereof, wherein the RNA inhibitory complex includes at least one double-stranded structure and a miRNA binding sequence, each of two strands of the miRNA binding sequence being bound to two strands of at least one end of the double-stranded structure, and the miRNA inhibitory complex further includes at least one crosslinked nucleic acid.Type: ApplicationFiled: September 16, 2016Publication date: August 9, 2018Inventors: Hideo Iba, Takeshi Haraguchi, Hirokazu Nankai, Hideaki Sato
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Patent number: 8563709Abstract: A miRNA-inhibiting RNA complex has a double-stranded structure, in which at least one RNA strand that includes a miRNA-binding sequence is linked to the two strands at at least one end of the double-stranded structure. The complex can efficiently inhibit miRNAs. In particular, RNAs in which two RNAs containing a miRNA binding sequence are positioned between two double-stranded structures were able to strongly inhibit miRNA. These RNAs can be expressed from, for example, a PolIII promoter, and by integration into a vector, miRNAs can be stably inhibited for a long period of time.Type: GrantFiled: March 2, 2011Date of Patent: October 22, 2013Assignee: The University of TokyoInventors: Hideo Iba, Takeshi Haraguchi
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Publication number: 20110245481Abstract: A miRNA-inhibiting RNA complex has a double-stranded structure, in which at least one RNA strand that includes a miRNA-binding sequence is linked to the two strands at at least one end of the double-stranded structure. The complex can efficiently inhibit miRNAs. In particular, RNAs in which two RNAs containing a miRNA binding sequence are positioned between two double-stranded structures were able to strongly inhibit miRNA. These RNAs can be expressed from, for example, a PolIII promoter, and by integration into a vector, miRNAs can be stably inhibited for a long period of time.Type: ApplicationFiled: March 2, 2011Publication date: October 6, 2011Applicant: THE UNIVERSITY OF TOKYOInventors: Hideo Iba, Takeshi Haraguchi
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Publication number: 20060153810Abstract: The present invention provides a process for preparing a retrovirus to be expressed at a high titer by specifically transferring a desired foreign gene into target cells. A pseudotyped retrovirus vector having a high titer can be prepared by transferring a DNA construction wherein a promoter, an loxP sequence, a VSV-G gene and a polyA addition signal are arranged in this order is transferred into cells carrying the retrovirus gag and pol gene expression systems, and then transferring a retrovirus vector containing the desired foreign gene thereinto, followed by the treatment with a recombinase.Type: ApplicationFiled: March 20, 2006Publication date: July 13, 2006Applicant: Eisai Co., Ltd.Inventors: Hideo Iba, Tohru Arai
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Patent number: 7056696Abstract: The present invention provides a process for preparing a retrovirus to be expressed at a high titer by specifically transferring a desired foreign gene into target cells. A pseudotyped retrovirus vector having a high titer can be prepared by transferring a DNA construction wherein a promoter, a loxP sequence, a VSV-G gene and a polyA addition signal are arranged in this order is transferred into cells carrying the retrovirus gag and pol gene expression systems, and then transferring a retrovirus vector containing the desired foreign gene thereinto, followed by the treatment with a recombinase.Type: GrantFiled: March 8, 2001Date of Patent: June 6, 2006Assignee: Eisai Co., Ltd.Inventors: Hideo Iba, Tohru Arai
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Patent number: 6743620Abstract: The present invention provides a process for preparing a retrovirus to be expressed at a high titer by specifically transferring a desired foreign gene into target cells. A pseudotyped retrovirus vector having a high titer can be prepared by transferring a DNA construction wherein a promoter, an loxP sequence, a VSV-G gene and a polyA addition signal are arranged in this order is transferred into cells carrying the retrovirus gag and pol gene expression systems, and then transferring a retrovirus vector containing the desired foreign gene thereinto, followed by treatment with a recombinase.Type: GrantFiled: January 5, 1999Date of Patent: June 1, 2004Assignee: Eisai Co., Ltd.Inventors: Hideo Iba, Tohru Arai
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Publication number: 20010018203Abstract: The present invention provides a process for preparing a retrovirus to be expressed at a high titer by specifically transferring a desired foreign gene into target cells. A pseudotyped retrovirus vector having a high titer can be prepared by transferring a DNA construction wherein a promoter, an loxP sequence, a VSV-G gene and a polyA addition signal are arranged in this order is transferred into cells carrying the retrovirus gag and pol gene expression systems, and then transferring a retrovirus vector containing the desired foreign gene thereinto, followed by the treatment with a recombinase.Type: ApplicationFiled: March 8, 2001Publication date: August 30, 2001Applicant: Eisai Co.Inventors: Hideo Iba, Tohru Arai