Patents by Inventor Hideo Sakakibara
Hideo Sakakibara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5563122Abstract: A safe, stabilized lyophilized preparation comprising parathyroid hormone (PTH) as an active ingredient and effective amounts of sugar and sodium chloride to provide a stable preparation of parathyroid hormone.Type: GrantFiled: September 6, 1994Date of Patent: October 8, 1996Assignee: Asahi Kasei Kogyo Kabushiki KaishaInventors: Ken Endo, Shinji Sato, Yoshinori Sugiyama, Masaru Ohno, Hideo Sakakibara
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Patent number: 5407911Abstract: A parathyroid hormone-containing emulsion for nasal administration, comprising parathyroid hormone as the active ingredient, at least, azacycloalkane derivative of the general formula [1]: ##STR1## wherein R is alkyl, m is an integer of 2-4, and n is an integer of 1-15, provided that R is alkyl of C.sub.5-11 in case where n is 1-3, as the absorption promotor, glycyrrhizic acid or its non-toxic salt, and a suitable amount of water.Type: GrantFiled: May 16, 1994Date of Patent: April 18, 1995Assignees: Asahi Kasei Kogyo Kabushiki Kaisha, Hisamitsu Keiyaku Kabushiki KaishaInventors: Nakayuki Yamamoto, Michihiko Sugimoto, Seiki Morimoto, Hideo Sakakibara, Masaru Saita, Yuji Shimozono, Takafumi Manako
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Patent number: 5281580Abstract: The present invention is to provide emulsion preparations for nasal administration containing calcitonins, which are safely and effectively administrated compared with the conventional calcitonin preparations. The emulsions are prepared by using a calcitonin as the active ingredient, an azacycloalkane derivative as the absorption promotor such as 1-[2-(decylthio)ethyl] azacyclopentan-2-one, and glycyrrhizic acid or its salt.Type: GrantFiled: July 23, 1991Date of Patent: January 25, 1994Assignees: Toyo Jozo Company, Ltd., Hisamitsu Pharmaceutical Co., Inc.Inventors: Nakayuki Yamamoto, Michihiko Sugimoto, Hideo Sakakibara, Masaru Saita, Yuji Shimozono, Takafumi Manako
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Patent number: 5059587Abstract: A nasal administration powder composition containing a physiologically active peptide as an active ingredient can be efficiently absorbed through nasal mucosa by the addition of a water-soluble organic acid as an absorption promoter. This composition may further contain a diluent. The water-soluble organic acid used as absorption promoter includes, for example, at least one of succinic acid, tartaric acid, citric acid, fumaric acid, maleic acid, malonic acid, glutaric acid, adipic acid, malic acid, L-glutamic acid, L-aspartic acid, gluconic acid and glucuronic acid.Type: GrantFiled: July 19, 1988Date of Patent: October 22, 1991Assignee: Toyo Jozo Company, Ltd.Inventors: Nakayuki Yamamoto, Hideo Sakakibara, Kimio Mizuno
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Patent number: 4868290Abstract: 4"-deoxy-3"-demethoxy-3"-methylene-desmycosin derivatives of the formula ##STR1## wherein R.sub.1 is hydrogen, acyl or substituted carbamoyl,R.sub.2 is ##STR2## R.sub.3 is hydrogen or a protective group for hydroxy, R.sub.4 is hydrogen, hydroxy or protected hydroxy, and Me is --CH.sub.3, and pharmaceutically acceptable salts thereof are produced.These novel derivatives have antibiotic properties superior to the known related antibiotics tylosin and desmycosin.Type: GrantFiled: November 25, 1987Date of Patent: September 19, 1989Assignee: Toyo Jozo Kabushiki KaishaInventors: Tatsuro Fujiwara, Tomoko Yashiro, Hideo Sakakibara
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Patent number: 4804749Abstract: 20-O-Acyl-19,20-enolmacrolide antibiotic derivatives represented by the following general formula (I): ##STR1##Type: GrantFiled: April 9, 1987Date of Patent: February 14, 1989Assignee: Toyo Jozo Co., Ltd.Inventors: Tatsuro Fijiwara, Hideyuki Watanabe, Hideo Sakakibara
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Patent number: 4797479Abstract: A compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are long-chain fatty acid residue, and Ns is nucleoside residue selected from the group consisting of 5-fluorouridine-5'-yl, 5-fluoro-2'-deoxyuridine-5'-yl-, bredinin-5'-yl, tubercidine-5'-yl-, neplanocin A-6'-yl-, 5-fluorocytidine-5'-yl-, arabinosylcytosine-5'-yl, arabinocyl-5-fluorocytosine-5'-yl-, arabinosyladenine-5'-yl- and arabinosylthymine-5 '-yl-, and pharmacologically acceptable salts thereof, having antitumor activity.Type: GrantFiled: April 15, 1986Date of Patent: January 10, 1989Assignee: Toyo Jozo Kabushiki KaishaInventors: Satoshi Shuto, Hiromichi Ito, Kiyofumi Fukukawa, Hideo Sakakibara, Masatoshi Tsujino
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Patent number: 4661588Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is lower alkyl, lower alkoxycarbonyl-lower alkyl, phenyl, phenyl substituted by one or more lower alkyl or halogen, phenyl-lower alkyl optionally substituted in its side chain by lower alkyl or lower alkoxycarbonyl, thienylmethyl or thiazolyl, R.sub.2 is hydrogen or lower alkyl, or ##STR2## constitutes a 3-7-membered nitrogen-containing heterocyclic ring in which R.sub.1 and R.sub.2 are connected, R.sub.3 is hydrogen or hydroxyl, and X is oxygen or sulfur, or a non-toxic salt thereof. These compounds have stronger antibacterial activity as compared with known clinically used macrolide antibiotics such as erythromycin, oleandomycin, josamycin and leucomycin, and also have strong antibacterial activity against all macrolide antibiotic-resistant strains such as macrolide-resistant A group strains (clinical isolates or erythromycin, oleandomycin and 16-membered macrolide antibiotic resistant strains).Type: GrantFiled: October 25, 1985Date of Patent: April 28, 1987Assignee: Toyo Jozo Kabushiki KaishaInventors: Tatsuro Fujiwara, Kazuyo Ohta, Eiichi Honda, Takao Hirano, Hideo Sakakibara
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Patent number: 4517296Abstract: Antibiotic acmimycin of the formula ##STR1## is active against Gram positive and Gram negative bacteria. It is produced by culturing the microorganism Streptomyces sp. AC4559 FERM P-6445, and isolating the above compound from the cultured medium.Type: GrantFiled: September 9, 1983Date of Patent: May 14, 1985Assignee: Toyo Jozo Kabushiki KaishaInventors: Hideo Sakakibara, Masashi Awata, Shuzo Satoi, Naoki Mutoh, Masaki Takada, Mitsuo Hayashi
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Patent number: 4515941Abstract: Novel 23-demycinosyldesmycosin derivatives are disclosed of the formula ##STR1## wherein A is oxygen or sulfur, R.sub.1 is optionally substituted phenyl or ##STR2## group, in which R.sub.3 is optionally substituted phenyl and R.sub.4 and R.sub.5 are the same or different and are hydrogen, lower alkyl or optionally substituted phenyl, and R.sub.2 is hydrogen or hydroxyl. The compounds or non-toxic salts thereof are useful as antibiotics.Type: GrantFiled: March 30, 1983Date of Patent: May 7, 1985Assignee: Toyo Jozo Kabushiki KaishaInventors: Tatsuro Fujiwara, Hideyuki Watanabe, Takao Hirano, Hideo Sakakibara
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Patent number: 4490524Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is optionally substituted phenyl, thienyl, 2-amino-4-thiazolyl or 2-chloroacetamido-4-thiazolyl; A is lower alkylene, lower alkenylene, or lower alkylene substituted by lower alkyl, amino, lower alkoxyimino or phenyl-Z-group wherein Z is a single bond or --S-- or --SO.sub.2 --, but when R.sub.1 is 2-amino-4-thiazolyl or 2-chloroacetamido-4-thiazolyl then A is lower alkylene substituted by lower alkoxyimino; R.sub.2 is hydrogen or hydroxyl; X is oxygen or sulfur and n=0 or 1, or a non-toxic salt thereof. These compounds have a stronger antibacterial activity against Gram positive bacteria as compared with known macrolide antibiotics such as erythromycin and tylosin, and also have an equivalent level of antibacterial activity against Gram negative bacteria as compared with that of erythromycin, and hence may be useful for clinical use. These compounds are also useful for feed additives and growth stimulants.Type: GrantFiled: January 24, 1983Date of Patent: December 25, 1984Assignee: Toyo Jozo Kabushiki KaishaInventors: Tatsuro Fujiwara, Hideyuki Watanabe, Takao Hirano, Hideo Sakakibara
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Patent number: 4482707Abstract: Antibiotic saccharocins of the formula ##STR1## wherein R is hydrogen (saccharocin) or hydroxyl (3'-oxysaccharocin) are produced by culturing a microorganism belonging to the genus Saccharopolyspora, for example Saccharopolyspora sp. AC 3440 FERM-P No. 6238, in a conventional nutrient medium, and separating the thus-produced saccharocins from the cultured medium. The noval saccharocins exhibit anti-bacterial activity against Gram negative bacteria.Type: GrantFiled: December 8, 1982Date of Patent: November 13, 1984Assignee: Toyo Jozo Kabushiki KaishaInventors: Hideo Sakakibara, Shuzo Satoi, Masashi Awata, Hitoshi Sagai, Mitsuo Hayashi, Naoki Muto, Masaki Takada
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Patent number: 4421911Abstract: A compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or hydroxy and at least one of R.sub.1 and R.sub.2 is hydrogen, or a pharmaceutically acceptable salt thereof, has strong antimicrobial and antibacterial activity..Type: GrantFiled: March 16, 1982Date of Patent: December 20, 1983Assignee: Toyo Jozo Kabushiki KaishaInventors: Tatsuro Fujiwara, Eiichi Honda, Hideo Sakakibara, Takao Hirano
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Patent number: 4415730Abstract: A compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or hydroxyl and at least one of R.sub.1 and R.sub.2 is hydrogen, or a pharmaceutically acceptable salt thereof, has antibacterial activity against Gram positive bacteria and against macrolide-resistant A group bacteria.Type: GrantFiled: June 23, 1982Date of Patent: November 15, 1983Assignee: Toyo Jozo Kabushiki KaishaInventors: Tatsuro Fujiwara, Eiichi Honda, Hideo Sakakibara, Takao Hirano
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Patent number: 4345069Abstract: Deformyltylosin derivatives of the formula ##STR1## wherein A is ##STR2## --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --, R.sub.1 is hydrogen, lower alkanoyl or aryl-lower alkanoyl, X.sub.1 and X.sub.2 are hydrogen or are connected to form a valence bond, Y.sub.1 and Y.sub.2 are hydrogen or are connected to form a valence bond, Q.sub.1 is hydrogen or methyl, Q.sub.2 is hydrogen or ##STR3## R.sub.2 is hydrogen or lower alkanoyl, R is hydrogen or ##STR4## R.sub.3 is hydrogen or C.sub.2-5 alkanoyl, and R.sub.4 is hydrogen or C.sub.2-6 alkanoyl, and when R.sub.3 is not hydrogen, then R.sub.4 is not hydrogen, or a pharmaceutically acceptable salt thereof, have strong antibacterial activities as compared to the known antibiotic tylosin, and also have enhanced antibacterial activities against all macrolide antibiotic-resistant strains such as A, B and C group strains, and have higher blood levels as compared with tylosin.Type: GrantFiled: September 5, 1980Date of Patent: August 17, 1982Assignee: Toyo Jozo Kabushiki KaishaInventors: Hideo Sakakibara, Tatsuro Fujiwara, Osamu Okegawa, Eiichi Honda, Susumu Watanabe, Tetsuo Matsuda
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Patent number: 4268665Abstract: Derivatives of antibiotic tylosin of the formula ##STR1## wherein R.sub.1 is hydrogen or lower alkanoyl, A.sub.1 and A.sub.2 are groups of which one is R.sub.2 and the other is R.sub.3, and R.sub.2 and R.sub.3 are C.sub.2-6 alkanoyl, or a physiologically acceptable salt thereof, have enhanced antibacterial activity against macrolide antibiotic-resistant strains.Type: GrantFiled: September 14, 1979Date of Patent: May 19, 1981Assignee: Toyo Jozo Kabushiki KaishaInventors: Hideo Sakakibara, Tatsuro Fujiwara, Osamu Okegawa, Toshiyuki Watanabe, Susumu Watanabe, Tetsuo Matsuda
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Patent number: 4242504Abstract: 3"-acylated macrolide antibiotics of the formula ##STR1## wherein R.sub.1 is hydrogen or C.sub.2-3 alkanoyl, R.sub.2 is hydrogen or C.sub.2-4 alkanoyl, at least one of R.sub.1 and R.sub.2 being hydrogen, and one of R' and R" being R.sub.3 and the other R.sub.4, R.sub.3 being C.sub.2-6 alkanoyl and R.sub.4 being C.sub.2-5 alkanoyl, or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 10, 1979Date of Patent: December 30, 1980Assignee: Toyo Jozo Kabushiki KaishaInventors: Hideo Sakakibara, Osamu Okegawa, Toshiyuki Watanabe, Tatsuro Fujiwara, Susumu Watanabe, Satoshi Omura, Tetsuo Matsuda