Patent number: 4430500
Abstract: A cephalosporin compound of the formula: ##STR1## wherein X is hydrogen, halogen, hydroxy, alkyloxy, aralkyloxy, aryloxy, mercapto, alkylthio, aralkylthio, arylthio, alkylsulfonyl, aralkylsulfonyl, arylsulfonyl, alkylsulfinyl, aralkylsulfinyl, arylsulfinyl, amino, mono-or di-alkylamino, mono- or di-aralkylamino, mono- or di-arylamino, acylamino, a sulfonic acid group, nitro, alkyl, aralkyl, aryl or a heterocyclic group; R is hydrogen, alkyl, aralkyl, aryl or a heterocyclic group, with all of the alkyl, aralkyl, aryl and heterocyclic ring groups in radicals X and R optionally being substituted with at least one substituent, is purified by (a) adjusting the pH of an aqueous solution containing said cephalosporin compound to be purified to within the range of 1.0 to 3.
Type:
Grant
Filed:
June 15, 1982
Date of Patent:
February 7, 1984
Assignee:
Ajinomoto Co., Inc.
Inventors:
Hideomi Saito, Tomoya Yamamoto, Masayuki Nomura, Tomoyoshi Hachiya
Patent number: 4423215
Abstract: A method of preparing sodium salts of an imidazoledicarboxylic acid derivative of a substituted cephalosporin represented by the general formula of ##STR1## where X is a radical selected from the group consisting of hydrogen, halogen, hydroxyl, alkyl, aryl, aralkyl, alkoxy, aryloxy, aralkyloxy, mercapto, alkylthio, arylthio, aralkylthio, alkylsulfonyl, arylsulfonyl, aralkylsulfonyl, alkylsulfinyl, arylsulfinyl, aralkylsulfinyl, amino, mono- or dialkylamino, mono- or diarylamino, mono- or diaralkylamino, acylamino, sulfonic acid, nitro or heterocyclic group;and where R is a radical selected from hydrogen, an organic radical such as alkyl, aryl or aralkyl or a heterocyclic group, said organic radical and heterocyclic group being optionally substituted;said method comprising reacting a compound represented by the following formula: ##STR2## with 4-pyridineethanesulfonic acid in an aqueous solution of sodium iodide and subsequently recovering the salt.
Type:
Grant
Filed:
March 2, 1982
Date of Patent:
December 27, 1983
Assignee:
Ajinomoto Company, Inc.
Inventors:
Naohiko Yasuda, Hisao Iwagami, Yasuo Irie, Eiji Nakanishi, Hideomi Saito