Patents by Inventor Hideshi Ishii

Hideshi Ishii has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220101147
    Abstract: The present disclosure relates to predicting trait information from the genetic information of individuals, and generating a model therefor. Learning is performed using a plurality of types of genetic information from a plurality of individuals, and a model for predicting trait information is generated. For said learning, it is possible to create images of the genetic information, and provide the same to said learning. The images in the present disclosure can store both sequence information and expression information. Moreover, the layout of genetic factors in the images can be optimized. Said learning can be performed as split learning, and the data after said split learning can be consolidated.
    Type: Application
    Filed: December 27, 2019
    Publication date: March 31, 2022
    Inventors: Masamitsu KONNO, Hideshi ISHII, Masaki MORI, Ayumu ASAI, Jun KOSEKI
  • Publication number: 20210308271
    Abstract: The present invention pertains to a ligand that contains a plurality of groups represented by formula (1) and is capable of multivalently binding to a glutamine transporter expressed in excess in a cancer cell compared to a normal cell.
    Type: Application
    Filed: August 17, 2017
    Publication date: October 7, 2021
    Applicants: TOKYO INSTITUTE OF TECHNOLOGY, OSAKA UNIVERISTY
    Inventors: Nobuhiro Nishiyama, Hiroyasu Takemoto, Takahiro Nomoto, Keishiro Tomoda, Makoto Matsui, Naoki Yamada, Yuto Honda, Hideshi Ishii, Masaki Mori, Masamitsu Konno
  • Publication number: 20210215669
    Abstract: A method of examining for cancer in a non-primate mammal such as a pet animal may include, for example, a method of examining or diagnosing for cancer in a non-primate mammal, including evaluating taxic behavior of nematodes toward a urine sample from a subject mammal.
    Type: Application
    Filed: August 14, 2019
    Publication date: July 15, 2021
    Applicant: Hirotsu Bio Science Inc.
    Inventors: Takaaki HIROTSU, Satoru KAIFUCHI, Toshimi SUGIMOTO, Hideshi ISHII, Masamitsu KONNO, Yuji UEDA, Shogo KOBAYASHI, Hidetoshi EGUCHI, Yuichiro DOKI, Masaki MORI
  • Publication number: 20210046190
    Abstract: An object to be achieved by the present invention is to provide a technique for enhancing the anticancer effect of ubenimex; in particular, enhancing its anticancer effect on solid cancer. This object can be achieved by a compound containing a chain structure in which a plurality of ubenimex molecules is linked to a chain polymer.
    Type: Application
    Filed: January 30, 2019
    Publication date: February 18, 2021
    Inventors: Masaki MORI, Hideshi ISHII, Masamitsu KONNO, Hidetoshi EGUCHI, Naotsugu HARAGUCHI, Reishi TOSHIYAMA, Nobuhiro NISHIYAMA, Hiroyasu TAKEMOTO
  • Publication number: 20140377768
    Abstract: The present invention provides a novel antitumor agent that acts through a novel mechanism. The novel antitumor agent contains as an active ingredient a substance capable of inhibiting a cell cycle-dependent Rho GTPase activating protein (RhoGAP). The RhoGAP is cell cycle-dependent and plays an important role in a process through which cancer cells acquire invasive capacity and/or metastatic capacity. The invasion and/or metastasis of cancer cells can be controlled by targeting the RhoGAP. Examples of the substance capable of inhibiting a cell cycle-dependent RhoGAP include an antisense oligonucleotide against a gene encoding the RhoGAP and an oligonucleotide that induces RNA interference of the gene. As the oligonucleotide, one containing an artificial nucleic acid such as BNA is preferred because of its excellent stability. The present invention also provides a screening method including selecting an antitumor agent capable of suppressing cancer cell invasion and/or metastasis through a novel mechanism.
    Type: Application
    Filed: January 28, 2013
    Publication date: December 25, 2014
    Applicant: Osaka University
    Inventors: Masaru Ishii, Yoshinori Kagawa, Masaki Mori, Hideshi Ishii
  • Patent number: 8852941
    Abstract: A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency. The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.
    Type: Grant
    Filed: February 18, 2011
    Date of Patent: October 7, 2014
    Assignee: Osaka University
    Inventors: Masaki Mori, Hideshi Ishii, Norikatsu Miyoshi, Yuichiro Doki, Masahiro Tanemura, Kenichi Nagai, Hiromitsu Hoshino, Yoshiaki Omura, Naotsugu Haraguchi, Susumu Miyazaki
  • Publication number: 20130065243
    Abstract: A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency. The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.
    Type: Application
    Filed: February 18, 2011
    Publication date: March 14, 2013
    Inventors: Masaki Mori, Hideshi Ishii, Norikatsu Miyoshi, Yuichiro Doki, Masahiro Tanemura, Kenichi Nagai, Hiromitsu Hoshino, Yoshiaki Omura, Naotsugu Haraguchi, Susumu Miyazaki
  • Patent number: 7777005
    Abstract: The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic, therapeutic, cell proliferation enhancement, and screening methods which involve these polynucleotides and protein. The invention further includes kits useful for performing the methods of the invention.
    Type: Grant
    Filed: November 21, 2006
    Date of Patent: August 17, 2010
    Assignee: Thomas Jefferson University
    Inventors: Carlo M Croce, Hideshi Ishii
  • Publication number: 20070072230
    Abstract: The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic, therapeutic, cell proliferation enhancement, and screening methods which involve these polynucleotides and protein. The invention further includes kits useful for performing the methods of the invention.
    Type: Application
    Filed: November 21, 2006
    Publication date: March 29, 2007
    Inventors: Carlo Croce, Hideshi Ishii
  • Patent number: 7141417
    Abstract: The invention relates to isolated polynucleotides homologous with a portion of one strand of the human tumor suppressor gene, FEZ1, and to the tumor suppressor protein encoded thereby, Fez1. The polynucleotides are useful, for example, as probes, primers, portions of expression vectors, and the like. The invention also includes diagnostic, therapeutic, cell proliferation enhancement, and screening methods which involve these polynucleotides and protein. The invention further includes kits useful for performing the methods of the invention.
    Type: Grant
    Filed: February 25, 2000
    Date of Patent: November 28, 2006
    Assignee: Thomas Jefferson University
    Inventors: Carlo M. Croce, Hideshi Ishii
  • Patent number: 4974198
    Abstract: A vector processing system prevents delays in reading microinstructions from a control memory during processing operations. The vector processing system permits a second microinstruction to be read from the control memory before processing is completed on a first microinstruction. Thus, delays caused by waiting for the processing to be completed on the first microinstruction before loading the next microinstruction are prevented. The disclosed vector processing system incorporates a start command hold flag that holds the start command from a second microinstruction until the processing initiated by the first microinstruction is completed.
    Type: Grant
    Filed: July 15, 1987
    Date of Patent: November 27, 1990
    Assignee: NEC Corporation
    Inventor: Hideshi Ishii
  • Patent number: 4882701
    Abstract: A branch instruction processing unit executes a branch-on-count (BCT) instruction for loop control of a program by means of pipeline control. The unit includes a memory for storing the number of loops for each BCT instruction, a first storage register for storing the output of the memory, a detection circuit for detecting if the output of the memory is a "1" while the output is stored in the first storage register, a second storage register for storing the output of the first storage register, and a branch judgement circuit which judges if each instruction is taken in response to the detection of a "1" by the detection circuit while the output of the first storage register is being stored in the second storage register.
    Type: Grant
    Filed: September 23, 1988
    Date of Patent: November 21, 1989
    Assignee: NEC Corporation
    Inventor: Hideshi Ishii
  • Patent number: 4476525
    Abstract: A pipeline-controlled data processing system includes decoding apparatus for decoding successive instructions and a detection device responsive to the decoding apparatus output for determining when a particular two-instruction sequence is present. When a first instruction calls for an operation to be executed and the execution result to be loaded into an arithmetic register, and when a second instruction immediately following the first instruction calls for the storing of the output of the arithmetic register into both a main memory unit and a cache memory, the execution result is simultaneously stored in all of the arithmetic register, main memory and cache memory.
    Type: Grant
    Filed: August 14, 1981
    Date of Patent: October 9, 1984
    Assignee: NEC Corporation
    Inventor: Hideshi Ishii