Patents by Inventor Hideshi Kumai

Hideshi Kumai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting early cancer
    Patent number: 7090983
    Abstract: MK (midkine) was found to rise in the blood or urine of patients with various types of cancers at early stage. Based on this finding, a method for detecting early cancer, comprising the step of measuring MK in blood or urine was completed.
    Type: Grant
    Filed: September 8, 2000
    Date of Patent: August 15, 2006
    Assignee: Muramatsu, Takashi
    Inventors: Takashi Muramatsu, Kohji Okamoto, Shinya Ikematsu, Munehiro Oda, Hideshi Kumai, Sadatoshi Sakuma
  • High level secretory expression system of intact MK family protein
    Patent number: 6867037
    Abstract: Under the regulation of a methanol-inducible alcohol oxidase gene (AOX1) promoter and a transcription termination sequence originating from Pichia pastoris, Pichia yeast, which has been transformed with an expression vector containing an MK family protein gene ligated to an a1 factor signal sequence originating from Saccharomyces cerevisiae, is cultured and an intact MK family protein is thus expressed and secreted in a large amount into the culture supernatant.
    Type: Grant
    Filed: August 10, 1999
    Date of Patent: March 15, 2005
    Assignee: Meiji Dairies Corp.
    Inventors: Akira Murasugi, Yukio Asami, Isao Kido, Hideshi Kumai
  • Treatment of peptic ulcers using midkine (MK) proteins
    Patent number: 6083907
    Abstract: An anti-ulcer composition is provided, which comprises as an active ingredient at least one of MK protein, its derivative having biological activity of MK protein, and their fragment having biological activity of MK protein, and a pharmaceutically acceptable carrier. The composition exhibits an effect for treating ulcer by promoting autotherapy without recurrence of ulcer.
    Type: Grant
    Filed: January 22, 1998
    Date of Patent: July 4, 2000
    Assignee: Meiji Milk Products Co., Ltd.
    Inventors: Masayuki Uchida, Shinya Ikematsu, Minehiko Yokoyama, Akio Yamashita, Hideshi Kumai, Munehiro Oda, Naoki Kato, Sadatoshi Sakuma, Takashi Muramatsu