Abstract: A method for producing a cysteine knot protein, the method including: producing the cysteine knot protein by culturing a transformed mammalian cell containing a gene encoding the cysteine knot protein and a gene encoding an exogenous chaperone protein in a protein production medium; and collecting the produced cysteine knot protein, wherein the chaperone protein includes one or more selected from the group consisting of HSP90?, HSP90?, CDC37, HSP70, HSP40, HSP60, HSP10, HSP110, and HSP27.

Abstract: This disclosure relates to a method of generating a symbol string based on an input sentence represented by a sequence of symbols. In particular, the method involves receiving an input symbol string representing a sentence, generating, using a neural network based on a sequence of dependency structure of elements in the input symbol string, an output symbol string corresponding to the input sentence. The neural network includes an encoder that converts elements of the input symbol string to a first hidden state in a form of a multi-dimensional vector, an attention mechanism that applies a weight to the first hidden state and generates the weighted first hidden state as a second hidden state, a decoder that generates a third hidden state based on at least one element of the input symbol string, an element of the output symbol string, and the second hidden state, and an output generator that generates an element of the output symbol string based on the second hidden state and the third hidden state.

Abstract: The present invention provides a kit for use in determining tauopathy or a dementia-related disease (excluding Alzheimer’s disease), containing an antibody that recognizes a polypeptide consisting of (1) the amino acid sequence shown in SEQ ID NO: 1, or (2) an amino acid sequence resulting from substitution, deletion, addition or insertion of one to several amino acids in the amino acid sequence shown in SEQ ID NO: 1, and the like.

Abstract: An object of the present invention is to provide a method for culturing one or more hematopoietic stem cells applicable to hematopoietic stem cell transplantation, and a method for producing such one or more hematopoietic stem cells.

Abstract: The present invention provides a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof with high selectivity for dopamine D4 receptors, which are useful for treating a disease such as attention deficit hyperactivity disorder. Specifically, a compound of formula (1) or a pharmaceutically acceptable salt thereof is provided, wherein n and m are independently 1 or 2; Ra is C1-6 alkyl group, C3-6 cycloalkyl group, or amino group; Rb is hydrogen atom, C1-6 alkyl group or the like, provided that when Ra is amino group, then Rb is hydrogen atom; Rc1 and Rc2 are independently hydrogen atom, or C1-6 alkyl group; Rd1 and Rd2 are independently hydrogen atom, fluorine atom or the like; ring Q is an optionally-substituted pyridyl group or an optionally-substituted isoquinolyl group; and the bond having a dashed line is a single or double bond.

Abstract: The present invention provides a cyclic aminomethyl pyrimidine derivative and a pharmaceutically acceptable salt thereof with high selectivity for dopamine D4 receptors, which are useful for treating a disease such as attention deficit hyperactivity disorder. Specifically, a compound of formula (1) or a pharmaceutically acceptable salt thereof is provided, wherein n and m are independently 1 or 2; Ra is C1-6 alkyl group, C3-6 cycloalkyl group, or amino group; Rb is hydrogen atom, C1-6 alkyl group or the like, provided that when Ra is amino group, then Rb is hydrogen atom; Rc1 and Rc2 are independently hydrogen atom, or C1-6 alkyl group; Rd1 and Rd2 are independently hydrogen atom, fluorine atom or the like; ring Q is an optionally-substituted pyridyl group or an optionally-substituted isoquinolyl group; and the bond having a dashed line is a single or double bond.