Abstract: It is an object to provide effective means for preventing and/or treating fulminant acute pneumonia. Provided are a pharmaceutical agent or pharmaceutical composition to be used for preventing and/or treating fulminant acute pneumonia, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing intra-alveolar neutrophil aggregation, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing pulmonary neutrophil infiltration, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), and a method of preventing and/or treating fulminant acute pneumonia, including administering a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody).

Abstract: It is an object to provide effective means for preventing and/or treating fulminant acute pneumonia. Provided are a pharmaceutical agent or pharmaceutical composition to be used for preventing and/or treating fulminant acute pneumonia, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing intra-alveolar neutrophil aggregation, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), an agent for suppressing pulmonary neutrophil infiltration, containing a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody), and a method of preventing and/or treating fulminant acute pneumonia, including administering a CD69 antagonist, such as an antibody that specifically recognizes CD69 (anti-CD69 antibody).

Abstract: A submerged nozzle for continuous casting of molten metal, wherein two or more discharge hole flow passages are provided on a cylindrical side surface of a submerged nozzle, and first and second inner surface side walls and first and second outer surface side walls of the discharge hole flow passages in a horizontal cross-section of the submerged nozzle when in use are composed by straight lines formed so as to be inflected at an inner side point of inflection and an outer side point of inflection.

Abstract: A submerged nozzle for continuous casting of molten metal, wherein two or more discharge hole flow passages are provided on a cylindrical side surface of a submerged nozzle, and first and second inner surface side walls and first and second outer surface side walls of the discharge hole flow passages in a horizontal cross-section of the submerged nozzle when in use are composed by straight lines formed so as to be inflected at an inner side point of inflection and an outer side point of inflection.

Abstract: An object of the invention is to provide a casting nozzle in which attachment and deposition of alumina or the like can be prevented while a drift of molten steel can be prevented. The casting nozzle according to the invention is characterized in that the casting nozzle has a molten steel flow hole portion in which “a plurality of independent protrusion portions and/or concave portions” are disposed so that each of the protrusion portions and/or concave portions has a size satisfying the expression (1): H?2 mm and the expression (2): L>2×H mm [in which “H” shows the maximum height of the protrusion portion or the maximum depth of the concave portion, and “L” shows the maximum length of a base portion of the protrusion portion or concave portion].

Abstract: An object of the invention is to provide a casting nozzle in which attachment and deposition of alumina or the like can be prevented while a drift of molten steel can be prevented. The casting nozzle according to the invention is characterized in that the casting nozzle has a molten steel flow hole portion in which “a plurality of independent protrusion portions and/or concave portions” are disposed so that each of the protrusion portions and/or concave portions has a size satisfying the expression (1): H?2 mm and the expression (2): L>2×H mm [in which “H” shows the maximum height of the protrusion portion or the maximum depth of the concave portion, and “L” shows the maximum length of a base portion of the protrusion portion or concave portion].