Abstract: The present disclosure relates to methods for treatment of mucopolysaccharidosis type I in a subject in need thereof by administering a pharmaceutical composition containing a fusion protein of an anti-human transferrin receptor antibody and human ?-L-iduronidase.

Abstract: A cooling mechanism includes a bottom wall (22) in contact with a combustion chamber, an upper wall (30), and a cooling passage (40) arranged between the bottom wall (22) and the upper wall (30). The cooling passage (40) includes a first passage (50) extending to a first direction, a second passage (60) extending to the first direction, and a connection section (70) connected with the first passage (50) and the second passage (60). The second passage (60) is arranged to have an offset to the first passage (50) in a second direction perpendicular to the first direction and along the bottom wall (22).

Abstract: An injection device, a combustor, and a rocket engine include a device main body partitioned into a fuel manifold and an oxidant manifold, and a plurality of injectors arranged at predetermined intervals in the device main body to inject fuel and oxidant into a combustion chamber, each of the injectors includes a LOx channel including a proximal end portion communicating with the oxidant manifold and a distal end portion communicating with the combustion chamber, a restrictor provided on the proximal end portion of the LOx channel and a GH2 channel including a proximal end portion communicating with the fuel manifold and a distal end portion communicating with the combustion chamber, and the restrictors have different shapes.

Abstract: A combustor and a rocket engine include an injection device that injects an oxidizing agent and fuel from an injecting surface, a combustion chamber that generates combustion gas by burning the oxidizing agent and the fuel injected from the injection device, a resonator communicatively connected with the combustion chamber via a communication passage, and a perforated plate provided in the communication passage.

Abstract: An injection device, a combustor, and a rocket engine include a device main body partitioned into a fuel manifold and an oxidant manifold, and a plurality of injectors arranged at predetermined intervals in the device main body to inject fuel and oxidant into a combustion chamber, each of the injectors includes a LOx channel including a proximal end portion communicating with the oxidant manifold and a distal end portion communicating with the combustion chamber, a restrictor provided on the proximal end portion of the LOx channel and a GH2 channel including a proximal end portion communicating with the fuel manifold and a distal end portion communicating with the combustion chamber, and the restrictors have different shapes.

Abstract: A cooling mechanism includes a bottom wall (22) in contact with a combustion chamber, an upper wall (30), and a cooling passage (40) arranged between the bottom wall (22) and the upper wall (30). The cooling passage (40) includes a first passage (50) extending to a first direction, a second passage (60) extending to the first direction, and a connection section (70) connected with the first passage (50) and the second passage (60). The second passage (60) is arranged to have an offset to the first passage (50) in a second direction perpendicular to the first direction and along the bottom wall (22).