Abstract: The invention provides an aryl ethynyl phthalic acid and derivatives thereof (including fluorine-containing compounds) represented by Formulae 1, 3, 5, 4A and 5A including the structure of Formula 2, and method of producing these compounds, in which an aryl ethynyl phthalic anhydride is formed by subjecting an aryl phthalic acid to ring closing:

Abstract: The invention provides a method for producing a compound represented by the following formula (II), comprising executing alkali hydrolysis of a compound represented by the following formula (I) with an alkali metal hydroxide in the presence of a barium compound to from the compound represented by formula (II), precipitating the barium compound in the form of a barium halide, and eliminating the barium halide: 1

Abstract: There is disclosed a method for producing an N-alkyl-.alpha.-dialkylaminoacetohydroxamic acid compound represented by formula (2), which comprises reacting an .alpha.-dialkylaminoacetic acid ester compound represented by formula (1) with an N-alkylhydroxylamine, wherein the reaction is carried out in water and an ether-series organic solvent, ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4, which are the same or different, each represents an alkyl group. According to the method, it is possible to obtain the objective compound in a high yield with a short reaction time, with restrained formation of a by-product.

Abstract: A bis-azo compound represented by the following general formula (1), a tautomer thereof or a salt thereof: ##STR1## wherein R represents a substituted or unsubstituted phenyl group or a substituted or unsubstituted heteroaryl group and X represents a substituted or unsubstituted phenylene group. These compounds exhibit low toxicity and do not have any undesirable effect such as mutagenecity.

Abstract: A peptide derivative containing 1 to 20 units of peptide unit represented by the following general formula [I] or a pharmaceutically acceptable salt thereof;[Z]--Arg--X--Asp--[Y] [I]wherein Arg represents L- or D-arginine residue, Asp represents L-aspartic acid residue, X represents L- or D-leucine, D-isoleucine, L- or D-norleucine, L- or D-phenylalanine, D-phenylglycine or D-alanine residue, and [Z] and [Y] each represents an amino acid or a peptide residue, which may be present or absent, selected from glycine, L-serine, L-threonine, L- and D-aspartic acid, L-alanine, L- and D-glutamic acid, L-proline residues and a peptide residue constituted by the foregoing amino acid residues, and a pharmaceutical composition comprising the peptide derivative. The composition of the present invention is useful as an agent for inhibiting tumor metastasis.

Abstract: A phosphorylating agent represented by the following general formula [1]: ##STR1## wherein R represents a protective group of the phosphoric acid; and X represents a heterocyclic residue represented by the following general formula [2]: ##STR2## wherein Y represents a single bond or an oxygen or sulfur atom; Z represents a heterocyclic nucleus comprising at least one nitrogen atom as a ring-forming element and may be condensed with another aromatic ring; and W represents one or more substituents other than a hydrogen atom. The phosphorylating agent is stable, can rapidly proceed phosphodiester bond-forming reactions in good selectivity under mild conditions and thus makes it possible to perform a reaction even in a relatively large scale.

Abstract: A compound represented by the following general formula I; ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 independently represent a hygrogen atom, alkyl group or aryl group, provided that at least one of R.sup.1, R.sup.2 and R.sup.3 represents 3,7,11,15-tetramethylhexadecyl group, 3,7,11-trimethyldodecyl group or 3,7-dimethyloctyl group, or a salt thereof. The compound may have R- or S- configuration with respect to each asymmetric carbon contained therein and it may be present as a racemate. The compounds of the present invention are useful as surfactants, lubricants, dispersants, emulsifiers, additives, stabilizers, solubilizers, water-repellants, antistatic agents and the like.

Abstract: A glycerol derivative or a salt thereof is provided and the derivative is represented by the following general formula (I): ##STR1## wherein n is an integer ranging from 1 to 3; R.sup.1 represents a hydrogen atom or a group: --P(O)(OR.sup.2)(OR.sup.3) wherein R.sup.2 represents a hydrogen atom or a protective group for the phosphoric acid residue and R.sup.3 represents a hydrogen atom, a protective group for the phosphoric acid residue or a hydrophilic group; provided that the phosphoric acid residue represented by R.sup.1 may be in the form of a salt wih a proper counter ion; and, in respect of stereochemistry of asymmetric carbon atoms present in the molecule, the derivative or salt may be either an optically active isomer or a racemic isomer.These compounds are excellent in biological compatibility, dispersibility and chemical stability and that they can provide membranes having high flowability and high barrier properties as compared with conventional phospholipids.

Abstract: A phosphatidylserine derivative represented by formulae (I), (II), and (III): ##STR1## wherein R represents a protective group which can be removed by an acid; and R' represents a straight chain or branched alkyl group having from 8 to 24 carbon atoms and may contain a substituent group, or may be unsaturated, provided that if an asymmetric carbon is present, the phosphatidylserine derivative is a racemic mixture or an optically active isomer thereof. Preferably, R represents a tertiary butoxycarbonyl group; R' represents a straight chain or branched alkyl group having 14, 16, or 18 carbon atoms; and the substituent is an alkylcarbonyl group, an alkoxycarbonyl group, a halogen atom, or an aryl group.