Patents by Inventor Hideto Ohno

Hideto Ohno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody specific to central nervous system tau protein
    Patent number: 7442516
    Abstract: The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable by using a polypeptide comprising an amino acid sequence of a connective portion between the amino acid sequence encoded by Exon 4 of a gene encoding a tau protein and the amino acid sequence encoded by Exon 5 thereof as an epitope specific to the isoform of tau protein predominantly existing in central nervous tissues. The present invention further provides a method of detecting Alzheimer's disease and a reagent kit using the antibody.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: October 28, 2008
    Assignees: Mitsubishi Chemical Corporation, Mitsubishi Kagaku Iatron, Inc.
    Inventors: Hideto Ohno, Koichi Ishiguro, Masaki Imagawa
  • Antibody specific to central nervous system tau protein
    Publication number: 20050181460
    Abstract: The present invention provides an antibody which specifically recognizes a CNS tau protein but not a peripheral tau protein. More specifically, the present invention provides an antibody obtainable by using a polypeptide comprising an amino acid sequence of a connective portion between the amino acid sequence encoded by Exon 4 of a gene encoding a tau protein and the amino acid sequence encoded by Exon 5 thereof as an epitope specific to the isoform of tau protein predominantly existing in central nervous tissues. The present invention further provides a method of detecting Alzheimer's disease and a reagent kit using the antibody.
    Type: Application
    Filed: February 11, 2005
    Publication date: August 18, 2005
    Inventors: Hideto Ohno, Koichi Ishiguro, Masaki Imagawa
  • Anti-thymosin .alpha.1 monoclonal antibody-producing hybridoma
    Patent number: 5643735
    Abstract: There are disclosed a hybridoma obtained by fusing a myeloma cell with an anti-thymosin .alpha.1 antibody-producing cell and selecting a hybridoma which produces a monoclonal antibody that recognizes the N-terminus of thymosin .alpha.1; an anti-thymosin .alpha.1 monoclonal antibody which is produced by the hybridoma, and a method for measuring thymosin .alpha.1 which comprises forming a three-component complex comprising thymosin .alpha.1, the anti-thymosin .alpha.1 monoclonal antibody (A), and an anti-thymosin .alpha.1 antibody (B) that recognizes a different site of thymosin .alpha.1 than antibody (A) does; forming a four-component complex of said three- component complex with a labeled substance (C) that specifically binds to antibody (A) or antibody (B) of the three-component complex; and detecting the labeled substance in said four-component complex.
    Type: Grant
    Filed: March 29, 1995
    Date of Patent: July 1, 1997
    Assignee: Yuka Medias, Co., Ltd.
    Inventors: Hiroyuki Yokoi, Takao Saito, Hideto Ohno