Patent number: 7291337
Abstract: The peptide in this invention is a peptide having affinity to gp120 represented by Formula (1): H-A1-A2-A3-A4-A5-R(SEQ ID No. 1) (in the formula, H means hydrogen, A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue, A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine, leucine, or tyrosine residue, A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue, A4 is alanine, tryptophan, or glycine residue, A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue, R is OH derived from carboxyl group or NH2 derived from acid amide group). The above peptide has an affinity to gp120 of the HIV envelope protein and is superior in stability.
Type:
Grant
Filed:
August 3, 2004
Date of Patent:
November 6, 2007
Assignee:
Aspion Co., Ltd.
Inventors:
Takeru Fujii, Hideakira Yokoyama, Hidetoshi Hamamoto
Publication number: 20050004040
Abstract: The peptide in this invention is a peptide having affinity to gp120 represented by Formula (1): H-A1-A2-A3-A4-A5-R (in the formula, H means hydrogen, A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue, A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine, leucine, or tyrosine residue, A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue, A4 is alanine, tryptophan, or glycine residue, A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue, R is OH derived from carboxyl group or NH2 derived from acid amide group). The above peptide has an affinity to gp120 of the HIV envelope protein and is superior in stability.
Type:
Application
Filed:
August 3, 2004
Publication date:
January 6, 2005
Inventors:
Takeru Fujii, Hideakira Yokoyama, Hidetoshi Hamamoto
Patent number: 6827939
Abstract: The peptide in this invention is a peptide having affinity to gp120 represented by
H-A1-A2-A3-A4-A5-R (SEQ ID No. 1) Formula (1)
(in the formula,
H means hydrogen,
A1 is aspartic acid, lysine, valine, glutamic acid, glycine, asparagine, or tyrosine residue,
A2 is valine, aspartic acid, tryptophan, lysine, phenylalanine, isoleucine, leucine, or tyrosine residue,
A3 is lysine, valine, aspartic acid, arginine, alanine, or tryptophan residue,
A4 is alanine, tryptophan, or glycine residue,
A5 is glycine, alanine, valine, leucine, isoleucine, serine, threonine, methionine, asparagine, glutamine, histidine, lysine, arginine, phenylalanine, tryptophan, proline, or tyrosine residue,
R is OH derived from carboxyl group or NH2 derived from acid amide group).
Type:
Grant
Filed:
January 11, 2001
Date of Patent:
December 7, 2004
Assignee:
MedRx Co., Ltd.
Inventors:
Takeru Fujii, Hideakira Yokoyama, Hidetoshi Hamamoto