Patents by Inventor Hideya SAKAGUCHI

Hideya SAKAGUCHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for maturation of retinal tissue containing continuous epithelium
    Patent number: 12534706
    Abstract: The present invention provides a method for maintaining a continuous epithelial structure of a retinal tissue including culturing the retinal tissue in a medium comprising a methyl group donor or a substrate of the methyl group donor at a concentration at which cell differentiation of a neural retinal progenitor cell is suppressed, and a neurite extension inhibitor at a concentration at which neurite extension is suppressed.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: January 27, 2026
    Assignees: RIKEN, RACTHERA CO., LTD.
    Inventors: Hideya Sakaguchi, Yoshiki Sasai, Mototsugu Eiraku, Daiki Nukaya, Atsushi Kuwahara
  • METHOD FOR MANUFACTURING TELENCEPHALON OR PROGENITOR TISSUE THEREOF
    Publication number: 20220098550
    Abstract: The present invention provides a method of producing more mature telencephalon or a progenitor tissue thereof, in vitro, from mammalian pluripotent stem cells, comprising obtaining a telencephalon marker-positive aggregate by culturing an aggregate of pluripotent stem cells in suspension in the presence of a Wnt signal inhibitor and a TGF? signal inhibitor, and further culturing the telencephalon marker-positive aggregate in suspension under a high oxygen partial pressure condition. In one embodiment, the suspension culture under a high oxygen partial pressure condition is performed in the presence of a Wnt signal enhancer and a bone morphogenetic factor signal transduction pathway activating substance.
    Type: Application
    Filed: December 13, 2021
    Publication date: March 31, 2022
    Applicants: RIKEN, Sumitomo Chemical Company, Limited
    Inventors: Yoshiki SASAI, Taisuke KADOSHIMA, Hideya SAKAGUCHI
  • Method for manufacturing telencephalon or progenitor tissue thereof
    Patent number: 11198850
    Abstract: The present invention provides a method of producing more mature telencephalon or a progenitor tissue thereof, in vitro, from mammalian pluripotent stem cells, comprising obtaining a telencephalon marker-positive aggregate by culturing an aggregate of pluripotent stem cells in suspension in the presence of a Wnt signal inhibitor and a TGF? signal inhibitor, and further culturing the telencephalon marker-positive aggregate in suspension under a high oxygen partial pressure condition. In one embodiment, the suspension culture under a high oxygen partial pressure condition is performed in the presence of a Wnt signal enhancer and a bone morphogenetic factor signal transduction pathway activating substance.
    Type: Grant
    Filed: November 21, 2014
    Date of Patent: December 14, 2021
    Assignees: RIKEN, Sumitomo Chemical Company, Limited
    Inventors: Yoshiki Sasai, Taisuke Kadoshima, Hideya Sakaguchi
  • METHOD FOR MATURATION OF RETINAL TISSUE CONTAINING CONTINUOUS EPITHELIUM
    Publication number: 20200208103
    Abstract: The present invention provides a method for maintaining a continuous epithelial structure of a retinal tissue including culturing the retinal tissue in a medium comprising a methyl group donor or a substrate of the methyl group donor at a concentration at which cell differentiation of a neural retinal progenitor cell is suppressed, and a neurite extension inhibitor at a concentration at which neurite extension is suppressed.
    Type: Application
    Filed: July 20, 2018
    Publication date: July 2, 2020
    Applicants: RIKEN, SUMITOMO DAINIPPON PHARMA CO., LTD., SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventors: Hideya SAKAGUCHI, Yoshiki SASAI (deceased), Mototsugu EIRAKU, Daiki NUKAYA, Atsushi KUWAHARA
  • METHOD FOR MANUFACTURING TELENCEPHALON OR PROGENITOR TISSUE THEREOF
    Publication number: 20160289635
    Abstract: The present invention provides a method of producing more mature telencephalon or a progenitor tissue thereof, in vitro, from mammalian pluripotent stem cells, comprising obtaining a telencephalon marker-positive aggregate by culturing an aggregate of pluripotent stem cells in suspension in the presence of a Wnt signal inhibitor and a TGF? signal inhibitor, and further culturing the telencephalon marker-positive aggregate in suspension under a high oxygen partial pressure condition. In one embodiment, the suspension culture under a high oxygen partial pressure condition is performed in the presence of a Wnt signal enhancer and a bone morphogenetic factor signal transduction pathway activating substance.
    Type: Application
    Filed: November 21, 2014
    Publication date: October 6, 2016
    Applicant: RIKEN
    Inventors: Yoshiki SASAI, Taisuke KADOSHIMA, Hideya SAKAGUCHI