Abstract: An object of the invention is to provide an operation mechanism, an endoscope, and a manufacturing method that can reliably fix an operation wire to a member to be operated. According to an operation mechanism of an aspect of the invention, since a sleeve member is caulked in a caulked shape where a twisted shape of a plurality of strands of an operation wire is maintained, the sleeve member is caulked while the strands are maintained in an original line contact state. Accordingly, since damages to the strands caused by a point contact state of the strands do not occur, the tensile strength and bending durability of the operation wire are improved and the operation wire can be reliably fixed to a member to be operated. Further, since the sleeve member, which is externally fitted to the operation wire, is fixed to the member to be operated, other fixing members are not required. Accordingly, a fixing portion can be reduced in size.

Abstract: An assay chip includes fluidic-channel member composed of a light-transmissive lower member and an upper member, forming a fluidic-channel therebetween, and a cover member fitted with the fluidic-channel member from the upper-member-side thereof. An inlet for injecting a sample solution into the fluidic-channel and a suction opening for sucking, from the downstream side, the injected sample solution, both communicating with the fluidic-channel, are formed on the upper surface of the upper member. A pot for carrying out predetermined pre-processing on the sample solution, a pot for first-reaction processing to bind a photoresponsive labeling substance to an analyte in the sample solution, an inlet insertion-hole for inserting the inlet, and a suction-opening insertion-hole for inserting the suction opening are linearly arranged on the upper surface of the cover member.

Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.

Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.

Abstract: A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first insoluble carrier (11). These three carriers (11), (12) and (13) are housed not in contact with each other. A pressing unit (18) having a pressing surface (18a) that is parallel to the detection portion (14) is provided on an inner surface of the second device part (20) facing the detection portion (14). The pressing surface (18a) is displaced by being pressed toward the detection portion (14), and presses, from the upper side of the first insoluble carrier (11), the second insoluble carrier (12) and the third insoluble carrier (13) onto the first insoluble carrier (11). The first device part (10) and the second device part (20) are joined together.

Abstract: A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first insoluble carrier (11). These three carriers (11), (12) and (13) are housed not in contact with each other. A pressing unit (18) having a pressing surface (18a) that is parallel to the detection portion (14) is provided on an inner surface of the second device part (20) facing the detection portion (14). The pressing surface (18a) is displaced by being pressed toward the detection portion (14), and presses, from the upper side of the first insoluble carrier (11), the second insoluble carrier (12) and the third insoluble carrier (13) onto the first insoluble carrier (11). The first device part (10) and the second device part (20) are joined together.

Abstract: An assay chip includes fluidic-channel member composed of a light-transmissive lower member and an upper member, forming a fluidic-channel therebetween, and a cover member fitted with the fluidic-channel member from the upper-member-side thereof. An inlet for injecting a sample solution into the fluidic-channel and a suction opening for sucking, from the downstream side, the injected sample solution, both communicating with the fluidic-channel, are formed on the upper surface of the upper member. A pot for carrying out predetermined pre-processing on the sample solution, a pot for first-reaction processing to bind a photoresponsive labeling substance to an analyte in the sample solution, an inlet insertion-hole for inserting the inlet, and a suction-opening insertion-hole for inserting the suction opening are linearly arranged on the upper surface of the cover member.

Abstract: It is a microfluidic device including a flowchannel in which liquid flows. The flowchannel includes a main channel and a pair of branch channels provided across the main channel from each other to be each connected to the main channel. The main channel includes a first zone, a second zone, and a coupling zone that connects the first zone and the second zone. The second zone is smaller than the first zone in a distance between a bottom surface and a ceiling surface. The coupling zone is configured such that the distance between the bottom surface and the ceiling surface thereof gradually decreases towards the second zone from the first zone. A connection zone provided in the main channel and connected to each of the pair of branch channels overlaps with the coupling zone.

Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.

Abstract: A device for assay can evenly develop solution, and performs highly accurate and sensitive measurement. A first device part (10) maintains a second insoluble carrier (12) and a third insoluble carrier (13) in such a manner that they overlap with each other at a detection portion (14) of a first insoluble carrier (11). These three carriers (11), (12) and (13) are housed not in contact with each other. A pressing unit (18) having a pressing surface (18a) that is parallel to the detection portion (14) is provided on an inner surface of the second device part (20) facing the detection portion (14). The pressing surface (18a) is displaced by being pressed toward the detection portion (14), and presses, from the upper side of the first insoluble carrier (11), the second insoluble carrier (12) and the third insoluble carrier (13) onto the first insoluble carrier (11). The first device part (10) and the second device part (20) are joined together.

Abstract: A container includes a container body having a short pipe shape in which one end is an open end and the other end is provided with a bottom plate which is formed with a pouring hole and a first sealing member which is joined to an end surface of the open end of the container body to seal the open end.

Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of each of the developing directions.

Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions.

Abstract: It is a microfluidic device including a flowchannel in which liquid flows. The flowchannel includes a main channel and a pair of branch channels provided across the main channel from each other to be each connected to the main channel. The main channel includes a first zone, a second zone, and a coupling zone that connects the first zone and the second zone. The second zone is smaller than the first zone in a distance between a bottom surface and a ceiling surface. The coupling zone is configured such that the distance between the bottom surface and the ceiling surface thereof gradually decreases towards the second zone from the first zone. A connection zone provided in the main channel and connected to each of the pair of branch channels overlaps with the coupling zone.

Abstract: A reaction method of performing an adsorption reaction in which a subject substance of analysis is specifically adsorbed in a first channel, the method includes: flowing a specimen liquid to a second channel connected to the first channel so that the specimen liquid is fed to the first channel, the specimen liquid containing the subject substance and a labeled substance that can be bonded to the subject substance; stopping feeding of the specimen liquid by detecting an event that a rear end of the specimen liquid flows into the first channel; joining a washing liquid to the rear end of the specimen liquid which stops in the first channel by flowing the washing liquid to a third channel that is converged to a connection portion of the second channel; and feeding the washing liquid to the first channel after the washing liquid is joined to the rear end.

Abstract: An object of the present invention is to provide a microchip whereby, when chemical analysis is conducted, a specimen liquid can be directly collected and weighed without using any collecting and weighing devices. The present invention provides a microchip for analyzing liquid samples, which has a measuring structure for weighing and collecting a given amount of a specimen liquid within a range of 0.05 to 10 ?l from an excessive amount of the specimen liquid which was introduced in the chip, wherein the measuring structure is located at the upstream side of an analysis element for analyzing a target substance in the specimen liquid inside the microchip.

Abstract: A reaction method of performing an adsorption reaction in which a subject substance of analysis is specifically adsorbed in a first channel, the method includes: flowing a specimen liquid to a second channel connected to the first channel so that the specimen liquid is fed to the first channel, the specimen liquid containing the subject substance and a labeled substance that can be bonded to the subject substance; stopping feeding of the specimen liquid by detecting an event that a rear end of the specimen liquid flows into the first channel; joining a washing liquid to the rear end of the specimen liquid which stops in the first channel by flowing the washing liquid to a third channel that is converged to a connection portion of the second channel; and feeding the washing liquid to the first channel after the washing liquid is joined to the rear end.

Abstract: The present invention provides an immunochromatographic device, which contains the following (a) and (b): (a) a first device part holding a first insoluble carrier used for developing a complex formed with an analyte and a labeling substance comprising a metal labeled with a first binding substance that can bind to the analyte and capturing the analyte and the labeling substance at a reaction portion containing a second binding substance that can bind to the analyte, and (b) a second device part holding a second insoluble carrier used for developing a liquid and a third insoluble carrier used for absorbing a liquid, in such a way that the first insoluble carrier does not come into contact with the second insoluble carrier and the third insoluble carrier.

Abstract: It is an object of the present invention to provide a measurement kit for developing a first developing solution and a second developing solution from different directions to suppress background noise, and an immunochromatography kit. The present invention provides a measurement kit, which comprises a first developing member for supplying a first developing solution and a second developing member for supplying a second developing solution, wherein the developing direction of the first developing solution is allowed to intersect with the developing direction of the second developing solution, so that development is carried out by developing the first and second developing solutions in different developing directions, and a water absorbent portion is established on the downstream of the developing directions.