Abstract: The present invention provides a heterocyclic compound having a HDAC6 inhibitory action, which is useful for the treatment of central nervous system diseases including neurodegenerative diseases, and the like, and a medicament comprising the compound. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the description, or a salt thereof.

Abstract: The system includes a memory that stores a trained model, and a processor. The processor acquires at least one treatment image including an image in which at least one energy device and at least one biological tissue are captured. The processor acquires information regarding an amount of energy supply, the information regarding an energy output setting of the energy device. The processor estimates, based on the treatment image, the information regarding the amount of energy supply, and the trained model, estimated remaining heat information regarding an amount of heat or a temperature of the energy device. The processor causes a notification section to make a notification based on the estimated remaining heat information.

Abstract: The system includes a memory that stores first and second trained models, and a processor. The processor acquires a captured image in which at least one energy device and at least one biological tissue are imaged. The processor detects a bounding box from the captured image by processing based on the first trained model and estimates the image recognition information from the captured image in the bounding box by processing based on the second trained model. The processor outputs an energy output adjustment instruction based on the estimated image recognition information to the generator. The generator controls the energy supply amount to the energy device based on the energy output adjustment instruction.

Abstract: A medical system can include a light source configured to generate excitation light; and a processor including a memory, the processor: controlling energy supplied to an energy device, the light source generating the excitation light to generate fluorescence from the living body tissue heat treated by the energy device; generating a fluorescence image based on an image pickup signal obtained by imaging the living body tissue; and generating a control signal that restricts energy supply to the energy device and output the control signal to the energy control apparatus when a pixel value of at least one pixel in the fluorescence image exceeds a first threshold value.

Abstract: A suture needle has: a flexible elongated shaft member; a passing mechanism for passing a suture needle between two gripping members, wherein the passing mechanism has fitting hole portions that are provided in the respective gripping members and that hold the suture needle in a fitting manner, a holding member movable in a direction intersecting the axis of each fitting hole portion and having a pressing surface which can press an outer circumferential surface of the suture needle held in the fitting hole portion, and a tensile-force-transmitting member coupled with the holding member and which can move along the longitudinal axis of the elongated shaft member, wherein the outer circumferential surface of the suture needle is pressed by the pressing surface against the inner circumferential surface of the fitting hole portion by the motion of the tensile-force-transmitting member.

Abstract: A suture needle has: a flexible elongated shaft member; a passing mechanism for passing a suture needle between two gripping members, wherein the passing mechanism has fitting hole portions that are provided in the respective gripping members and that hold the suture needle in a fitting manner, holding member movable in a direction intersecting the axis of each fitting hole portion and having a pressing surface which can press an outer circumferential surface of the suture needle held in the fitting hole portion, and a tensile-force-transmitting member coupled with the holding member and which can move along the longitudinal axis of the elongated shaft member, wherein the outer circumferential surface of the suture needle is pressed by the pressing surface against the inner circumferential surface of the fitting hole portion by the motion of the tensile-force-transmitting member.

Abstract: A surgical instrument includes an insertion part; a base having a bottom part; first grasping surface; second grasping surface; a plurality of staple disposed between the base and the first grasping surface; first and second staple line consist of the plurality of staple; a groove part; a traction member; a locked part having first and second locked part; and a blade part accommodated in the groove part so as to be capable of advancing and retracting along the longitudinal axis, wherein the first and second wall surfaces are provided to be apart from each other in the cross direction such that when the blade part is positioned between the first and second locked parts in the cross direction, gaps both between the blade part and the first locked part and between the blade part and the second locked part are capable of being formed.

Abstract: A treatment device includes a first energy output portion that is disposed in one of a pair of holding portions and includes first and second operation regions; and a second energy output portion that is disposed in the other holding portion of the pair of holding portions and includes third and fourth operation regions. The first operation region projects toward the second energy output portion more than the second operation region. The third operation region projects toward the first energy output portion more than the fourth operation region. Each of the first and third operation regions includes steps.

Abstract: A treatment device which applies energy to a biological tissue to treat the biological tissue, includes: an interlocking mechanism that regulates at least one of a closing time until first and second jaws reach a closed state from an opened state when one operation is input into an operating body for a handle, and a unit closing amount from the opened state toward the closed state, interlocks at least one of the first and second jaws with the operating body, and is interposed between the operating body and the handle; and an elastic member that is disposed in the interlocking mechanism, couples the operating body with the handle, pulls the operating body toward the handle at a constant load or a constant pressure, and regulates the closing time until the closed state is reached from the opened state.

Abstract: A treatment system includes: an absorbent member which is arranged to be discharged into the biological tissues as the fusion targets from the first jaw, thermally deformed when the thermal energy is applied thereto; a first energy discharge portion which is configured to discharge the absorbent member toward the second holding surface, and which is configured to supply the high-frequency energy and the thermal energy to the biological tissues; a second energy discharge portion which is configured to come into contact with at least a part of the absorbent member when the absorbent member is discharged, and which is configured to supply the high-frequency energy and the thermal energy to the biological tissues; and a control unit which is configured to control the energy source to supply the thermal energy after discharging the absorbent member to the biological tissues.

Abstract: A surgical device which is configured to apply energy to living tissue and to be used to perform a surgical procedure includes a grasping portion, an incising portion, an introduction portion and a treatment portion. The grasping portion grasps the living tissue having a first surface and a second surface. The incising portion is movable forward and backward with respect to the living tissue and incises the living tissue. The introduction portion is movable forward and backward with respect to the living tissue and introduces a biocompatible material, which is chemically bound with the living tissue, to a space between the first surface and the second surface. The treatment portion is configured to apply high-frequency energy and thermal energy to the living tissue.

Abstract: A surgical treatment device which is used together with an endoscope, includes a sheath, a treatment portion which is arranged at the distal end portion of the sheath and includes first to third electrodes configured to treat a living tissue by using electrical energy, an operation portion which is arranged at a proximal end portion of the sheath and which is configured to operate the treatment portion, and a switching portion which is configured to switch between a first mode in which a treatment is given by using the first electrode and at least one of the second and third electrodes in the treatment portion and a second mode in which a treatment is given by using the second and third electrodes.

Abstract: A treatment method for a living tissue using energy includes a first step of outputting energy to a grasped living tissue and raising a temperature of cells of the grasped living tissue, a second step of, after the first step, outputting high-frequency energy to the grasped living tissue and destroying cell membranes of the grasped living tissue to discharge proteins in the cells to the outside of the cells, and a third step of, after the second step, outputting heat energy to the living tissue and welding the proteins to each other while dehydrating the grasped living tissue.

Abstract: A treatment method for a living tissue using energy includes a first step of outputting high-frequency energy to grasped living tissues to destroy cell membranes of the grasped living tissues, allowing proteins to flow out of cells and joining the living tissues to each other, and a second step of, after the first step, outputting heat energy to the grasped living tissues to dehydrate the grasped living tissues.

Abstract: An endoscopic surgical instrument includes an insertion section which is inserted into a body cavity, and a surgical section which is disposed on a tip of the insertion section and treats an object. The surgical section includes a body section, and a first electrode, a second electrode, and a third electrode which are disposed on the body section. The surgical section coagulates and cuts the object by using a combination of not less than two of the first electrode, the second electrode, and the third electrode.

Abstract: According to one aspect of the present invention, there is provided a treatment device for cutting a living tissue, comprising a main unit which is to be inserted into a body, a tip-end treatment portion which is disposed at a tip end of the main unit to cut the living tissue, a notch groove which is disposed at the tip-end treatment portion and which compresses the living tissue guided into the notch groove, and an electrode which is positioned in a part of the notch groove and which electrically cuts the living tissue compressed by the notch groove.

Abstract: A cutter for a blood vessel tissue harvesting instrument is disposed at the distal end of an insertion member. A cutter body projecting from the distal end of the insertion member includes a slit that extends from the distal end toward a base edge. High-frequency electrodes are disposed along the sides of the slit. A feeding mechanism has rotating surfaces which are rotated as a result of being pressed by the tissue, and which feed the tissue toward the base edge of the slit. The rotating surfaces are provided by two rotary members disposed opposite each other along the two side edges of the slit, respectively, so that the first and second rotating surfaces move in a direction from the opening of the slit toward the base edge of the slit.

Abstract: An ultrasound-guided ablation method captures an objective area to be ablated in an ultrasound scan area of an ultrasound transducer and delineates the objective area on an ultrasound image; specifies an ablation target area to display the ablation target area with a margin necessary for ablating the objective area on the ultrasound image processed by an ultrasound observation device and displayed on a display device; ablates, by an ablation device, the ablation target area displayed on the ultrasound image; and checks, on the ultrasound image, that an ablated area ablated by the ablation device has reached the ablation target area displayed on the ultrasound image.

Abstract: The body tissue harvesting instrument is provided with a cutter which is disposed at the distal end of an insertion member that is inserted into the body to sever tissue inside the body. The cutter includes a slit that extends from the distal end toward the base end; a first high-frequency electrode disposed along the two side edges of the slit on the outer surface of the cutter body and a second high-frequency electrode disposed at the base end of the slit; and a mechanism which is disposed on both sides of the distal end of the slit in the projection of the cutter body which rotates as a result of being pressed by the tissue, and which feeds the tissue toward the interior of the slit. Parts located on both sides of the distal end of the slit in the projection may mutually separate in the thickness direction.

Abstract: A living-body tissue removing apparatus includes a grip portion, an inserting portion which is connected to the grip portion and is inserted in the body, and an air feed channel which feeds predetermined air in the inserting portion so as to discharge the predetermined air from an opening arranged to the inserting portion.