Abstract: A compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy is provided. The present inventors have conducted studies on a compound useful as an active ingredient of a pharmaceutical composition for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy, and confirmed that a heteroaryl carboxamide compound has DGK ? (DGKzeta) inhibitory effect, leading to completion of the present invention. The heteroaryl carboxamide compound of the present invention has DGK ? inhibitory effect, and can be used as a therapeutic agent for treatment of cancer related to activation of immune cells or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody therapy.

Abstract: A valve timing control apparatus for an internal combustion engine includes a housing having a housing body and shoes protruding from an inner circumferential surface of the housing body to define actuation spaces therebetween, a vane rotor disposed in the housing and having a rotor body and vanes protruding from an outer circumferential surface of the rotor body to divide the actuation spaces into circumferentially alternating first and second hydraulic chambers, a plurality of spring units arranged in at least either the first hydraulic chambers or the second hydraulic chambers to bias the vane rotor in a rotational direction with respect to the housing, and a rotation restriction mechanism capable of restricting a relative rotation of the housing and the vane rotor to prevent the shoes and the vanes from contact with each other within the hydraulic chambers in which the spring units are arranged.

Abstract: A valve timing control apparatus for an internal combustion engine includes a housing having a housing body and shoes protruding from an inner circumferential surface of the housing body to define actuation spaces therebetween, a vane rotor disposed in the housing and having a rotor body and vanes protruding from an outer circumferential surface of the rotor body to divide the actuation spaces into circumferentially alternating first and second hydraulic chambers, a plurality of spring units arranged in at least either the first hydraulic chambers or the second hydraulic chambers to bias the vane rotor in a rotational direction with respect to the housing, and a rotation restriction mechanism capable of restricting a relative rotation of the housing and the vane rotor to prevent the shoes and the vanes from contact with each other within the hydraulic chambers in which the spring units are arranged.

Abstract: A variable valve timing control apparatus for an internal combustion engine comprising a housing member rotated in synchronism with one of a first shaft and a second shaft, the housing member comprising a circular space provided therein and at least one fan-shaped space radially extending from an outer circumferential surface of the circular space, a vane rotor rotated in synchronism with the other of the first shaft and the second shaft, the vane rotor is accommodated in the housing member in order to relatively rotate with respect to the housing member, the vane rotor comprising at least one vane radially extending so as to divide each the fan-shaped space into a first chamber and a second chamber, a locking member provided in one of the housing member and the vane, the locking member comprising a main body portion provided with a cylindrical shape and a leading head portion provided with a tapered surface whose diameter decreases toward an end face of the leading head portion, an engaging bore provided in

Abstract: In a valve open-and-closure timing changing apparatus for an internal combustion engine, a rotary body (3) is revolved in synchronization with a revolution of the engine, a camshaft (1) is provided, and a valve open-and-closure changing mechanism is interposed between the rotary body and the camshaft to relatively rotate the camshaft to the rotary body to enable a change in a valve open-and-closure timing of at least one of intake and exhaust valves.

Abstract: A variable valve timing control apparatus for an internal combustion engine that varies the rotational phrase of the first shaft with respect to the second shaft. The apparatus comprises a housing member rotated in synchronism with one of the first shaft and the second shaft, the housing member having a circular space provided in the housing member and radially extending at least one fan-shaped space from outer circumferential surface of the circular space, a vane rotor rotated in synchronism with the other of the first shaft and the second shaft and accommodated in the housing member in order to relatively rotate with respect to the housing member, the vane rotor having radially extending at least one vane so as to divide the fan-shaped space into first chamber and second chamber.

Abstract: A variable valve timing control apparatus for an internal combustion engine that varies the rotational phrase of the first shaft with respect to the second shaft. The apparatus comprises a housing member rotated in synchronism with one of the first shaft and the second shaft, the housing member having a circular space provided in the housing member and radially extending at least one fan-shaped space from outer circumferential surface of the circular space, a vane rotor rotated in synchronism with the other of the first shaft and the second shaft and accommodated in the housing member in order to relatively rotate with respect to the housing member, the vane rotor having radially extending at least one vane so as to divide the fan-shaped space into first chamber and second chamber.

Abstract: A valve timing control device disposed between a rotary element synchronously rotating with an engine and a camshaft actuating the engine valve, comprising a housing adapted to rotate with one of the rotary element and the camshaft and a vane rotor within the housing. The vane rotor has an axial bore having an open end and pressure chamber-side fluid passages open to the axial bore and is adapted to rotate with the other of the rotary element and the camshaft. Vanes radially extending from the vane rotor define within the housing fluid pressure chambers communicating with the pressure chamber-side fluid passages, respectively. A fluid control mechanism controls supply and discharge of a hydraulic fluid relative to the fluid pressure chambers. A shaft is received in the axial bore and formed with pressure source-side fluid passages connecting the pressure chamber-side fluid passages with the fluid control mechanism.

Abstract: An internal combustion engine has a sprocket driven by a timing chain in synchronization with the engine rotation and a camshaft for driving intake or exhaust valves. A valve timing control device of the engine comprises a first rotating member on which the sprocket is integrally formed; a second rotating member capable of making a relative rotation to the first rotating member and rotated together with the camshaft; a plurality of working fluid chambers defined between the first and second rotating members; and a charging/discharging means for charging and discharging a working fluid to and from the working fluid chambers to induce the relative rotation between the first and second rotating members. The sprocket and at least a base part of the first rotating member on which the sprocket is integrally formed are constructed of a porous metal member.

Abstract: A piston for an internal combustion engine includes a ring land formed with a piston-ring groove, and a skirt connected to the ring land so that the piston-ring groove is adjacent thereto, the skirt being formed with a piston-pin hole with an axis, and having a plane including the axis of the piston-pin hole. A taper is formed on the skirt in a first portion thereof nearer to the ring land than the plane to converge on the ring land.