Patents by Inventor Hideyuki Okano

Hideyuki Okano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210040445
    Abstract: A method for producing a tau-related disease model is provided. The method includes three-dimensionally culturing pluripotent stem cells having a mutation in a Microtubule Associated. Protein Tau (MAPT) gene to form a nerve organoid, and dissociating the nerve organoid into single cells and performing two-dimensional adherent culture to obtain neurons, in which the neurons are a tau-related disease model.
    Type: Application
    Filed: August 4, 2020
    Publication date: February 11, 2021
    Applicant: Keio University
    Inventors: Mari NAKAMURA, Seiji SHIOZAWA, Hideyuki OKANO
  • Patent number: 10898492
    Abstract: This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, e.g., adolescents and adults.
    Type: Grant
    Filed: June 13, 2018
    Date of Patent: January 26, 2021
    Assignee: Massachusetts Eye and Ear Infirmary
    Inventors: Albert Edge, Hideyuki Okano, Masato Fujioka, Kunio Mizutari
  • Publication number: 20200400619
    Abstract: A standard-moisture generator includes a flow controller configured to control a flow of a gas, a dryer connected to the flow controller, configured to absorb water molecules in the gas and to generate a dry gas having a background moisture, a moisture cell connected to the dryer, configured to add an object moisture to the dry gas, and a delay member connected to the moisture cell, configured to pass the dry gas with a delay time depending on a concentration of the background moisture in the dry gas.
    Type: Application
    Filed: February 12, 2019
    Publication date: December 24, 2020
    Applicant: Ball Wave Inc.
    Inventors: Yusuke TSUKAHARA, Osamu HIRAYAMA, Nobuo TAKEDA, Toshihiro TSUJI, Kazushi YAMANAKA, Toru OIZUMI, Hideyuki FUKUSHI, Nagisa SATO, Shingo AKAO, Tatsuhiro OKANO
  • Publication number: 20200325453
    Abstract: To produce and/or maintain naïve pluripotent stem cells capable of highly expressing genes important for maintaining an undifferentiated state, which could not be achieved by known methods for producing pluripotent stem cells. The present invention can produce naïve pluripotent stem cells capable of maintaining an undifferentiated state by introducing and allowing transient expression of six genes (Oct3/4, Klf4, c-Myc, Sox2, Nanog, and Klf2) among the so-called initializing factors, and further performing culturing in a medium containing LIF, an MEK inhibitor, a GSK3 inhibitor, a cAMP production promoter, a TGF-? inhibitor and a PKC inhibitor. Thus, the problem of the present invention can be solved.
    Type: Application
    Filed: June 30, 2020
    Publication date: October 15, 2020
    Applicants: ONO PHARMACEUTICAL CO., LTD., KEIO UNIVERSITY
    Inventors: Hideyuki OKANO, Seiji Shiozawa, Fumihiko Kisa
  • Publication number: 20200318064
    Abstract: Provided is an agent for accelerating maturation or aging of cells. An agent for accelerating maturation or aging of cells, comprising KU-60019 as an active ingredient.
    Type: Application
    Filed: October 11, 2019
    Publication date: October 8, 2020
    Applicant: JUNTENDO EDUCATIONAL FOUNDATION
    Inventors: Wado AKAMATSU, Takahiro Shiga, Naoko Kuzumaki, Hideyuki Okano
  • Publication number: 20200299643
    Abstract: A culture medium for inducing a pluripotent stem cell into a differentiation-promoted pluripotent stem cell, the medium including a Glycogen synthase kinase 3? (GSK3?) inhibitor, a Bone morphogenic protein (BMP) signaling inhibitor, and a Transforming growth factor (TGF)-? inhibitor as active ingredients.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 24, 2020
    Inventors: Hideyuki OKANO, Wado AKAMATSU, Koki FUJIMORI, Takuya MATSUMOTO, Naoko KUZUMAKI, Fumihiko KISA
  • Patent number: 10738280
    Abstract: To produce and/or maintain naïve pluripotent stem cells capable of highly expressing genes important for maintaining an undifferentiated state, which could not be achieved by known methods for producing pluripotent stem cells. The present invention can produce naïve pluripotent stem cells capable of maintaining an undifferentiated state by introducing and allowing transient expression of six genes (Oct3/4, Klf4, c-Myc, Sox2, Nanog, and Klf2) among the so-called initializing factors, and further performing culturing in a medium containing LIF, an MEK inhibitor, a GSK3 inhibitor, a cAMP production promoter, a TGF-? inhibitor and a PKC inhibitor. Thus, the problem of the present invention can be solved.
    Type: Grant
    Filed: March 17, 2016
    Date of Patent: August 11, 2020
    Assignees: ONO PHARMACEUTICAL CO., LTD., KEIO UNIVERSITY
    Inventors: Hideyuki Okano, Seiji Shiozawa, Fumihiko Kisa
  • Publication number: 20200225190
    Abstract: A collimated beam (23) of a surface acoustic wave propagates on a piezoelectric substrate (22) while passing through sensitive film (25) to adsorb a sensing gas. Signal processing unit (40) transmits an exciting burst signal to sensor electrode (24) to excite the collimated beam (23), receives first and second returned burst signals after the collimated beam (23) has propagated, and calculates a target gas parameter by a target leakage factor of the background gas and a relation between reference gas parameters and reference leakage factors of reference gases, the leakage factor is provided by first and second attenuations of the first and second returned burst signals, respectively, using waveform data of the first and second returned burst signals.
    Type: Application
    Filed: January 30, 2019
    Publication date: July 16, 2020
    Applicant: Ball Wave Inc.
    Inventors: Kazushi YAMANAKA, Nobuo TAKEDA, Shingo AKAO, Toshihiro TSUJI, Toru OIZUMI, Hideyuki FUKUSHI, Tatsuhiro OKANO, Nagisa SATO, Yusuke TSUKAHARA
  • Patent number: 10429512
    Abstract: A navigation signal transmitting apparatus, provided on ground, for transmitting a navigation signal to a receiver capable of positioning by receiving a spread spectrum satellite positioning signal from a satellite has first and second transmission antennas; a message generating unit that generates a message signal of positional information included in the navigation signal, and a modulating unit that modulates the message signal by a modulation process including spectrum spreading, based on spread codes of the same sequence as the satellite positioning signal allotted in advance to the navigation signal transmitting apparatus, for generating first and second navigation signals. The modulating unit executes the modulating process using either one of the first and second navigation signals as an object of demodulation at each time of reception by the receiver.
    Type: Grant
    Filed: May 11, 2011
    Date of Patent: October 1, 2019
    Assignee: GNSS Technologies Inc.
    Inventors: Hideyuki Torimoto, Kazuki Okano
  • Patent number: 10328385
    Abstract: A pump housing of the carbon dioxide-containing gas recovery apparatus is formed with a first chamber and a second chamber partitioned by a partition wall. The first and second chambers and communicate with each other through a third chamber. The first chamber communicates with a water supply opening and a carbon dioxide-containing gas inlet. When blown against water filling the first chamber, a carbon dioxide-containing gas is dissolved in the water, and the carbon dioxide-containing gas remaining undissolved exists as bubbles in the water. When a pair of six-blade rotors oppositely disposed on two axes and in the third chamber compress the bubbles to be refined into different bubbles, the carbon dioxide-containing gas can further be dissolved in the water by a compression action. An aqueous solution of carbon dioxide-containing gas is discharged from a water outlet communicating with the second chamber.
    Type: Grant
    Filed: June 21, 2016
    Date of Patent: June 25, 2019
    Assignee: Anlet Co., Ltd.
    Inventors: Yasuna Yokoi, Toshiaki Kato, Hideyuki Okano, Yoshinobu Ito
  • Publication number: 20190153387
    Abstract: A method is provided for uniformly differentiating a pluripotent stem cell into a neural stem cell, with elimination of variation among cell strains or clones of the pluripotent stem cell and without formation of an embryoid body, regardless of the origin of the pluripotent stem cell
    Type: Application
    Filed: February 14, 2017
    Publication date: May 23, 2019
    Inventors: Hideyuki OKANO, Wado AKAMATSU, Koki FUJIMORI, Tomoko NODA, Takayuki ANDOH, Toshiki TEZUKA, Takuya MATSUMOTO
  • Publication number: 20180369253
    Abstract: This invention relates to methods for treating hearing loss associated with loss of cochlear hair cells, e.g., caused by noise exposure, using certain gamma secretase inhibitors, in post-neonatal animals, e.g., adolescents and adults.
    Type: Application
    Filed: June 13, 2018
    Publication date: December 27, 2018
    Inventors: Albert Edge, Hideyuki Okano, Masato Fujioka, Kunio Mizutari
  • Patent number: 10041040
    Abstract: A method for differentiating a human differentiated cell-derived pluripotent stem cell into a neural stem cell is provided, which includes the steps of: making an embryoid body from the human differentiated cell-derived pluripotent stem cell; and culturing the embryoid body in a medium containing LIF to differentiate into a neural stem cell, so that, when the neural stem cell is allowed to differentiate in vitro after multiple subculturing of the neural stem cell, it differentiate mainly into neurons but substantially not into glial cells.
    Type: Grant
    Filed: February 3, 2010
    Date of Patent: August 7, 2018
    Assignee: Keio University
    Inventors: Hideyuki Okano, Yohei Okada, Masaya Nakamura
  • Publication number: 20180185783
    Abstract: [Problem] Providing a carbon dioxide-containing gas recovery-apparatus which is low in cost and can improve a carbon dioxide-containing gas recovery efficiency. [Overcoming Means] A pump housing 11 of the carbon dioxide-containing gas recovery apparatus 10 is formed with a first chamber 23 and a second chamber 26 partitioned by a partition wall 20a. The first and second chambers 23 and 26 communicate with each other through a third chamber 20. The first chamber 23 communicates with a water supply opening and a carbon dioxide-containing gas inlet. When blown against water filling the first chamber, a carbon dioxide-containing gas is dissolved in the water, and the carbon dioxide-containing gas remaining undissolved exists as bubbles A in the water. When a pair of six-blade rotors 40 oppositely disposed on two axes 41a and 41b in the third chamber 20 compress the bubbles A to be refined into bubbles B, the carbon dioxide-containing gas can further be dissolved in the water by a compression action.
    Type: Application
    Filed: June 21, 2016
    Publication date: July 5, 2018
    Inventors: Yasuna YOKOI, Toshiaki KATO, Hideyuki OKANO, Yoshinobu ITO
  • Publication number: 20180080009
    Abstract: To produce and/or maintain naïve pluripotent stem cells capable of highly expressing genes important for maintaining an undifferentiated state, which could not be achieved by known methods for producing pluripotent stem cells. The present invention can produce naïve pluripotent stem cells capable of maintaining an undifferentiated state by introducing and allowing transient expression of six genes (Oct3/4, Klf4, c-Myc, Sox2, Nanog, and Klf2) among the so-called initializing factors, and further performing culturing in a medium containing LIF, an MEK inhibitor, a GSK3 inhibitor, a cAMP production promoter, a TGF-? inhibitor and a PKC inhibitor. Thus, the problem of the present invention can be solved.
    Type: Application
    Filed: March 17, 2016
    Publication date: March 22, 2018
    Applicants: ONO PHARMACEUTICAL CO., LTD., KEIO UNIVERSITY
    Inventors: Hideyuki OKANO, Seiji SHIOZAWA, Fumihiko KISA
  • Publication number: 20170340586
    Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2-OH or —CH2—CH2OH, and X is ?O, (H, H) or (H, OH).
    Type: Application
    Filed: January 13, 2016
    Publication date: November 30, 2017
    Inventors: Makoto HOSOYA, Masato FUJIOKA, Hideyuki OKANO, Kaoru OGAWA, Tatsuo MATSUNAGA
  • Publication number: 20170333403
    Abstract: An object of the present invention is to provide novel apoptosis inhibitors and therapeutic agents for inner ear hearing impairment. As a pharmaceutical agent for this purpose, biguanide compounds represented by the following structural formula (I) or a rapamycin derivative represented by the following structural formula (II) as an active ingredient is provided: wherein R1 to R7 are each independently selected from a hydrogen atom, a halogen atom, or a C1-6 alkyl group, a C3-8 cycloalkyl group, a C6-10 aryl group, a 5- or 6-membered heteroaryl group, or a 5- or 6-membered non-aromatic heterocyclic group, each of which may have a substituent selected from a halogen atom, a cyano group, a C1-6 alkyl group, a C1-6 alkoxy group, a C1-6 alkoxy carbonyl group, a C3-8 cycloalkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, and a phenyl group; wherein R1 is a C1-6 alkyl or a C3-6 alkynyl, R2 is H, —CH2—OH or —CH2—CH2—OH, and X is ?O, (H, H) or (H, OH).
    Type: Application
    Filed: July 19, 2017
    Publication date: November 23, 2017
    Inventors: Makoto HOSOYA, Masato FUJIOKA, Hideyuki OKANO, Kaoru OGAWA, Tatsuo MATSUNAGA
  • Publication number: 20170204374
    Abstract: The present invention aims to obtain a method for quality evaluation of human mesenchymal stem cells, a method for isolation, selection and culture of human mesenchymal stem cells, a cell population of rapidly proliferating human mesenchymal stem cells, as well as monoclonal antibodies that specifically recognize rapidly proliferating human mesenchymal stem cells. From a cell population containing human mesenchymal stem cells, rapidly proliferating human mesenchymal stem cells are isolated, selected and cultured. The abundance ratio of cells expressing Ror2 or Fzd5 in the cell population thus isolated, selected and cultured is quantified to determine whether or not each cell population is acceptable.
    Type: Application
    Filed: July 31, 2015
    Publication date: July 20, 2017
    Applicant: PUREC CO., LTD.
    Inventors: Yumi IYOKU, Hideyuki OKANO, Yo MABUCHI
  • Patent number: 9399759
    Abstract: In order to provide a method for producing neural stem cells easily and quickly by inducing differentiation of somatic cells directly into neurospheres, dedifferentiation factors are introduced into somatic cells, which are then cultured in suspension in the presence of growth factors to produce the neurospheres, thereby allowing the neural stem cells to be produced quickly without establishing iPS cells.
    Type: Grant
    Filed: November 4, 2009
    Date of Patent: July 26, 2016
    Assignee: Keio University
    Inventors: Wado Akamatsu, Hideyuki Okano
  • Patent number: 9394516
    Abstract: An object of the present invention to provide an agent for promoting the self-renewal of the neural stem cells and a method of using the same. ECF-L contained in a culture supernatant of endothelial progenitor cells derived from bone marrow has an effect of promoting the self-renewal of neural stem cells. Accordingly, ECF-L can be used as an ingredient of an agent for promoting the self-renewal of the neural stem cells, a pharmaceutical composition for growing the neural stem cells, and a pharmaceutical composition for treating a disease associated with neural dysfunction.
    Type: Grant
    Filed: April 26, 2011
    Date of Patent: July 19, 2016
    Assignee: Keio University
    Inventors: Jun Namiki, Hideyuki Okano