Abstract: The present invention relates to a novel combination of (1) a substance that suppresses or inhibits the function of extracellular TCTP (translationally controlled tumor protein), especially released from tumor cells, and (2) a cancer immunotherapeutic agent for the treatment of cancer. Preferably, such a cancer immunotherapeutic agent is an immune checkpoint inhibitor. The substance that suppresses or inhibits the function of extracellular TCTP functions as an activator or enhancer of anti-tumor immune cells including T cells and natural killer (NK) cells and/or an antagonist of immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs), in the tumor immune microenvironment (TIME). The combination according to the present invention is useful for treating or preventing cancer. The combination according to the present invention is also useful for alleviating, reverting, or preventing immune suppression in the tumor immune microenvironment.

Abstract: The present invention is intended to identify a modulatory substance of the tumor immune microenvironment, and to provide a therapeutic utilization method of the modulatory substance. Specifically, the present invention relates to an inhibitor of the accumulation of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment (TIME), wherein the inhibitor comprises, an active ingredient, a substance that suppresses or inhibits the function of an immunomodulator released from dead tumor cells. More specifically, the present invention relates to the aforementioned inhibitor comprising a substance that suppresses or inhibits the function of, for example, TCTP (translationally controlled tumor protein).

Abstract: An industrial two-layered fabric includes a front side fabric with warps and wefts and a back side fabric with warps and wefts. The front and back side fabrics are bound by binding warps. A first pair of warps consists of the front side warp and back side warp. A second pair of warps consists of two binding warps. A mutually complementary structure presents where one of the two binding warps forms consecutive knuckles on the front surface while another one of the two binding warps does not emerge on the front surface side, and where the another one of the two binding warps forms consecutive knuckles on the front surface whereas the one of the two binding warps does not emerge on the front surface side. A back side warp and an adjacent binding warp form knuckles below a one back side weft and another one back side weft.

Abstract: The object of the present invention is to provide an industrial two-layered fabric including binding wefts which is capable of improving a high adhesivity of the fabric on the front and back surface sides and the supportability of the warps, without deteriorating the surface smoothness, the abrasion resistance on the back surface side, the extension resistance in the longitudinal direction and the hydration property, which have been conventionally desired.

Abstract: An industrial two-layer fabric includes an upper surface side fabric constituted by upper surface side warps and upper surface side wefts, one a lower surface side fabric constituted by lower surface side warps and lower surface side wefts, the upper surface side warps include a warp binding yarn, wherein two adjacent upper surface side warps that includes a upper surface side warp that weaves only the upper surface side wefts and the warp binding yarn form a pair, the warp binding yarn of the pair passes below three of the adjacent upper surface side wefts where the warp binding yarn passes below the one of the lower surface side wefts, a ratio of the number of the upper surface side warps to the number of the lower surface side is 2:1.

Abstract: According to the present invention, the curling or lifting of webs that occurs during the production nonwoven fabrics, and wrinkles that form on the surface of nonwoven fabrics are prevented. Also, the webs can be easily taken off without making grip stronger than necessary. The present invention pertains to an industrial fabric formed by weaving warp and weft, wherein an embossed pattern having a concavo-convex shape is formed in the vicinity of the apex of a knuckle portion exposed on the surface side of the warp and/or weft. In particular, the industrial fabric is characterized in that the warp and/or weft having the embossed pattern are plastic monofilaments.

Abstract: Provided is an industrial two-layer fabric satisfying basic characteristics of a fabric. The industrial two-layer fabric pertaining to the present invention has at least a first structure and a second structure in the weave repeat thereof, the first structure being formed by a combination of two upper-surface-side warps and a single lower-surface-side warp, the second structure being formed by a single upper-surface-side warp and a single lower-surface-side warp, the first structure and the second structure being disposed adjacent to each other, the upper-surface-side warps in the first structure being formed by a warp binding yarn having the function of binding an upper-surface-side fabric and a lower-surface-side fabric, the combination of two upper-surface-side warps forming the first structure being disposed adjacent to each other and constituting a partial rib weave at the surface of the upper-surface-side fabric.

Abstract: The object of the present invention is to provide a fabric with a thinned thickness which exhibits excellent rigidity, good anti-extension property, good wear resistance, good hydration property and good surface smoothness property. The present invention includes one upper surface side fabric constituted by warps on the surface side and upper surface side wefts, one lower surface side fabric constituted by lower surface side warps and lower surface side wefts, at least one warps on the surface side function as a warp binding yarn, two warps on the upper surface side are woven to form a pair on the upper surface side as the ribbed cord fabric, a ratio of the number of the warps on the upper surface side to that of the warps on the lower surface side is 2:1.

Abstract: The object of the present invention is to provide an industrial two-layered fabric including binding wefts which is capable of improving a high adhesivity of the fabric on the front and back surface sides and the supportability of the warps, without deteriorating the surface smoothness, the abrasion resistance on the back surface side, the extension resistance in the longitudinal direction and the hydration property, which have been conventionally desired.

Abstract: A metal adsorbent which can adsorb a wide variety of metals, can conform to various uses, and adsorbs metals in large amounts. Metal adsorbents in various forms, which have the property of highly efficiently adsorbing metals, are produced by (a) a method in which a polyamine polymer is chemically bonded and immobilized to a porous support, (b) a method in which a polyamine polymer is blended into a solution of a raw material for fibers and the mixture is formed into fibers by wet-spinning or dry spinning, and (c) a method in which a polyamine polymer is blended into a solution of a film-forming polymer and the mixture is formed into a film by a method of film formation from solution.

Abstract: Provided are an inhibitor of activation of an immune response mediated by an HMGB protein, the inhibitor containing at least one compound selected from the group consisting of a phosphorothioate oligonucleotide and a derivative thereof, and a method of screening for an inhibitor or enhancer of activation of an immune response mediated by an HMGB protein.

Abstract: A metal adsorbent which can adsorb a wide variety of metals, can conform to various uses, and adsorbs metals in large amounts. Metal adsorbents in various forms, which have the property of highly efficiently adsorbing metals, are produced by (a) a method in which a polyamine polymer is chemically bonded and immobilized to a porous support, (b) a method in which a polyamine polymer is blended into a solution of a raw material for fibers and the mixture is formed into fibers by wet-spinning or dry spinning, and (c) a method in which a polyamine polymer is blended into a solution of a film-forming polymer and the mixture is formed into a film by a method of film formation from solution.

Abstract: A metal adsorbent which can adsorb a wide variety of metals, can conform to various uses, and adsorbs metals in large amounts. Metal adsorbents in various forms, which have the property of highly efficiently adsorbing metals, are produced by (a) a method in which a polyamine polymer is chemically bonded and immobilized to a porous support, (b) a method in which a polyamine polymer is blended into a solution of a raw material for fibers and the mixture is formed into fibers by wet-spinning or dry spinning, and (c) a method in which a polyamine polymer is blended into a solution of a film-forming polymer and the mixture is formed into a film by a method of film formation from solution.

Abstract: Provided are an inhibitor of activation of an immune response mediated by an HMGB protein, the inhibitor containing at least one compound selected from the group consisting of a phosphorothioate oligonucleotide and a derivative thereof, and a method of screening for an inhibitor or enhancer of activation of an immune response mediated by an HMGB protein, the method including a mixing step of mixing an HMGB protein and a labeled nucleic acid in the presence and absence of a test substance; a quantifying step of quantifying the HMGB protein bound to the labeled nucleic acid; and a determination step of determining that the test substance is an inhibitor of activation of an immune response mediated by the HMGB protein when the amount of the HMGB protein bound to the labeled nucleic acid in the presence of the test substance is less than the amount of the HMGB protein bound to the labeled nucleic acid in the absence of the test substance and determining that the test substance is an enhancer of activation of an i

Abstract: A metal adsorbent which can adsorb a wide variety of metals, can conform to various uses, and adsorbs metals in large amounts. Metal adsorbents in various forms, which have the property of highly efficiently adsorbing metals, are produced by (a) a method in which a polyamine polymer is chemically bonded and immobilized to a porous support, (b) a method in which a polyamine polymer is blended into a solution of a raw material for fibers and the mixture is formed into fibers by wet-spinning or dry spinning, and (c) a method in which a polyamine polymer is blended into a solution of a film-forming polymer and the mixture is formed into a film by a method of film formation from solution.

Abstract: A heat exchanger which is constructed such that combustion gas passages 4 for passage of combustion gas and air passages 5 for passages of air are arranged alternately, and the heat exchanger is cut at one end side thereof in an unequal angle configuration to form combustion gas passage inlets 11 and air passage outlets 16, and cut at the other end side thereof in an unequal angle configuration to form combustion gas passage outlets 12 and air passage inlets 15. the combustion gas passage inlets 11 and combustion gas passage outlets 12, through which a combustion gas having a larger volume flow rate passes, are formed on a long side of an angle, and the air passage inlets 15 and air passage outlets 16, through which an air having a smaller volume flow rate passes, are formed on a short side of an angle.

Abstract: First heat-transfer plates S1 and second heat-transfer plates S2 are radially arranged between a larger diameter cylindrical-shaped outer casing 6 and a smaller diameter cylindrical-shaped inner casing 7 to form combustion gas passages 4 and air passages 5 alternately in a circumferential direction, and a multiplicity of projections 22, 23 formed on both surfaces of the first heat-transfer plates S1 and second heat-transfer plates S2 are jointed to one another at tip ends thereof. Pitches P between adjacent projections 22, 23 are changed in a radial direction to make the number of heat transfer units substantially constant in a radial direction to uniformize temperature distributions on the first heat-transfer plates S1 and second heat-transfer plates S2 in the radial direction, thereby avoiding a decrease in heat exchanging efficiency and generation of unwanted thermal stress.

Abstract: First heat transfer plates S1 and second heat transfer plates S2 folded along crest folding lines L1 and valley folding lines L2 are bonded to an inner periphery of an outer casing 6 and an outer periphery of an inner casing 7, so that the first and second heat transfer plates S1 and S2 are disposed radiately, thereby forming combustion gas passages and air passages circumferentially alternately. One end of both the combustion gas passages and the air passages is cut into an angle shape, and one side and the other side of the angle shape are closed to form combustion gas passage inlets 11 and air passage outlets 16. In a similar manner, combustion gas passage outlets 12 and air passage inlets 15 are formed at the other end of the combustion gas passages and the air passages. Thus, it is possible to provide a heat exchanger which has a simple structure and is easy to manufacture, and in which the pressure loss due to bending of flow paths can be suppressed to the minimum.