Patents by Inventor Hikaru Itani

Hikaru Itani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazo[4,5-b]-pyridiniummethyl-containing cephem compounds having broad antibacterial spectrum activity
    Patent number: 6800621
    Abstract: A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA. wherein, X is N or CY and Y is H or halogen; R1 is amino or protected amino; R2 is hydrogen or optionally substituted lower alkyl etc.; R3 is hydrogen etc.; R4 is hydrogen, optionally substituted lower alkyl, or optionally substituted N-containing heterocyclic group etc.; R5 is hydrogen etc.; and a wavy line means syn- or anti-isomerism or a mixture thereof.
    Type: Grant
    Filed: December 13, 2002
    Date of Patent: October 5, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yasuhiro Nishitani, Hikaru Itani, Tadashi Irie
  • Sulfate of cephem compound
    Publication number: 20040157821
    Abstract: The present invention provides sulfates of cefem compound (I) of the following formula, solvates thereof or crystals of the same, which are of high quality and useful as medicines such as an injection.
    Type: Application
    Filed: October 3, 2003
    Publication date: August 12, 2004
    Inventors: Hikaru Itani, Tadashi Irie, Fumihiko Matsubara, Hidetoshi Myojyo
  • Imidazo[4,5-b]-pyridinium-containing cephem compounds having broad antibacterial spectrum activity
    Publication number: 20030149014
    Abstract: A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA.
    Type: Application
    Filed: December 13, 2002
    Publication date: August 7, 2003
    Applicant: Shionogi & Co., Ltd.
    Inventors: Yasuhiro Nishitani, Hikaru Itani, Tadashi Irie
  • Imidazo[4,5-b]pyridiniummethyl-containing cephem compounds having broad antibacterial spectrum
    Patent number: 6518263
    Abstract: A cefem compound of the formula (I) shows wide antibacterial spectrum against various pathogenic bacteria including MRSA. wherein, X is N or CY and Y is H or halogen; R1 is amino or protected amino; R2 is hydrogen or optionally substituted lower alkyl etc.; R3 is hydrogen etc.; R4 is hydrogen, optionally substituted lower alkyl, or optionally substituted N-containing heterocyclic group etc.; R5 is hydrogen etc.; and a wavy line means syn- or anti-isomerism or a mixture thereof.
    Type: Grant
    Filed: May 25, 2001
    Date of Patent: February 11, 2003
    Assignee: Shionogi & Co., Ltd.
    Inventors: Yasuhiro Nishitani, Hikaru Itani, Tadashi Irie
  • Process for producing halomethylcarbapenems
    Patent number: 5064954
    Abstract: A functionallized intermediate for antibacterial carbapenems, 2-halomethylcarbapenem (III) is effectively synthesized by treating 2-hydroxymethylcarbapenem (I) with a phosphorylating reagent to give 2-phosphoryloxymethylcarbapenem (II) and then treating this product with a halogenating reagent. Some carbapenems derived from the intermediate are also disclosed. ##STR1## wherein, R.sup.1 is hydrogen or substituted or unsubstituted alkyl;R.sup.2 is hydrogen or substituted or unsubstituted alkyl;R.sup.3, R.sup.4 is halogen or substituted or unsubstituted alkoxy or aryloxy;R.sup.5 is hydrogen or carboxy protecting group; andHal is halogen.
    Type: Grant
    Filed: October 10, 1990
    Date of Patent: November 12, 1991
    Assignee: Shionogi & Co., Ltd.
    Inventors: Shoichiro Uyeo, Mitsuru Imuta, Hisao Ona, Hikaru Itani
  • Production of 1-oxacephams and intermediates
    Patent number: 4539148
    Abstract: Useful intermediates, 7.alpha.-acylamino-3-(oxo or exomethylene)-1-dethia-1-oxacepham-4.alpha.-carboxylates, are produced by the intramolecular carbenoid insertion of a 2-diazo-3-(oxo or exomethylene)-4-(3.alpha.-acylamino-2-oxoazetidin-4.beta.-yl)oxybutyrate prepared in several steps from the corresponding oxazolinoazetidinone and diketone.
    Type: Grant
    Filed: August 16, 1983
    Date of Patent: September 3, 1985
    Assignee: Shionogi & Co., Ltd.
    Inventors: Sadao Yamamoto, Hikaru Itani, Hiromi Takahashi, Teruji Tsuji, Wataru Nagata
  • Penicillin oxides
    Patent number: 4081443
    Abstract: Compounds of the formula: ##STR1## (where COB is carboxy or protected carboxy and X is hydrogen or nucleophilic group)preparable by oxidation of the corresponding N-nitrosopenicillin derivatives are useful as starting materials for synthesizing known and useful cephalosporins.
    Type: Grant
    Filed: June 15, 1977
    Date of Patent: March 28, 1978
    Assignee: Shionogi & Co., Ltd.
    Inventors: Shoichiro Uyeo, Hikaru Itani, Tsutomu Aoki, Teruji Tsuji, Wataru Nagata