Patents by Inventor Hila Isenberg

Hila Isenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Letrozole purification process
    Patent number: 7465749
    Abstract: Provided is a process for purifying a letrozole product that contains an isoletrozole impurity, which process preferably includes converting at least a portion of the isoletrozole impurity into 4,4?-dicyanobenzophenone and removing 4,4?-dicyanobenzophenone, to produce a purified letrozole product.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: December 16, 2008
    Assignee: Chemagis, Ltd.
    Inventors: Michal Hasson, Hila Isenberg, Efrat Manoff, Moshe Bentolila, Oded Friedman, Lior Zelikovitch
  • Letrozole purification process
    Publication number: 20070112203
    Abstract: Provided is a process for purifying a letrozole product that contains an isoletrozole impurity, which process preferably includes converting at least a portion of the isoletrozole impurity into 4,4?-dicyanobenzophenone and removing 4,4?-dicyanobenzophenone, to produce a purified letrozole product.
    Type: Application
    Filed: August 3, 2006
    Publication date: May 17, 2007
    Applicant: CHEMAGIS LTD.
    Inventors: Michal Hasson, Hila Isenberg, Efrat Manoff, Moshe Bentolila, Oded Friedman, Lior Zelikovitch
  • Process for alkylating secondary amines and the use in donepezil preparation thereof
    Publication number: 20060122227
    Abstract: The present invention relates to an improved process of alkylating secondary amines, more particularly of alkylating compounds having amino piperidinic group, which are useful as donepezil intermediates, wherein an alcohol serves as reaction facilitator thus enabling to obtain donepezil and salts thereof in high quality and yield. The present invention also relates to the prevention of unwanted alkylation of donepezil precursors, having amino piperidinic group, by using suitable reaction conditions.
    Type: Application
    Filed: September 27, 2005
    Publication date: June 8, 2006
    Inventors: Lior Zelikovitch, Oded Arad, Mohammed Alnabari, Yana Sery, Orna Kurlat, Moshe Bentolila, Aric Abadayev, Hanit Marom, Hila Isenberg, Joseph Kaspi