Patents by Inventor Hila Sberro

Hila Sberro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotides encoding BREX system polypeptides and methods of using same
    Patent number: 10767156
    Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: September 8, 2020
    Assignee: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
    Inventors: Rotem Sorek, Hila Sberro, Tamara Goldfarb
  • BACTERIAL ANTI-PHAGE DEFENSE SYSTEMS
    Publication number: 20160287677
    Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.
    Type: Application
    Filed: April 18, 2016
    Publication date: October 6, 2016
    Applicant: Yeda Research and Development Co. Ltd.
    Inventors: Rotem SOREK, Hila SBERRO, Azita LEAVITT
  • POLYNUCLEOTIDES ENCODING BREX SYSTEM POLYPEPTIDES AND METHODS OF USING SAME
    Publication number: 20160281053
    Abstract: Isolated polynucleotides encoding a BREX system are provided. Accordingly there is provided an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ and at least one of pglX, pglXI, brxP, brxHI, brxHII, brxL, brxD, brxA, brxB, brxF, and brxE, with the proviso that said BREX system does not comprise pglW, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same; Also provided is an isolated polynucleotide encoding a BREX system comprising a nucleic acid sequence encoding the BREX system comprising brxC/pglY, pglZ, pglX, pglW and at least one of brxD and brxHI, and wherein said BREX system confers phage resistance to a bacteria recombinantly expressing same. Also provided are compositions and methods for conferring phage resistance to bacteria or for conferring bacterial susceptibility to phages.
    Type: Application
    Filed: October 14, 2014
    Publication date: September 29, 2016
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Rotem SOREK, Hila SBERRO, Tamara GOLDFARB
  • Bacterial anti-phage defense systems
    Patent number: 9353359
    Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.
    Type: Grant
    Filed: December 26, 2013
    Date of Patent: May 31, 2016
    Assignee: Yeda Research and Development Co. Ltd.
    Inventors: Rotem Sorek, Hila Sberro, Azita Leavitt
  • BACTERIAL ANTI-PHAGE DEFENSE SYSTEMS
    Publication number: 20140178353
    Abstract: An isolated polypeptide is disclosed comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 2773-5544 and 11089-11094, wherein the polypeptide has antimicrobial activity. Uses thereof for treating microbial infections are also disclosed.
    Type: Application
    Filed: December 26, 2013
    Publication date: June 26, 2014
    Applicant: Yeda Research and Development Co., Ltd.
    Inventors: Rotem SOREK, Hila Sberro, Azita Leavitt
  • Detection of heart failure using a photoplethysmograph
    Patent number: 7803118
    Abstract: A method for diagnosis includes receiving a signal associated with blood oxygen saturation of a patient during sleep. The signal is filtered so as to eliminate signal components at frequencies equal to and greater than a respiratory frequency of the patient. The filtered signal is processed to detect a pattern corresponding to multiple cycles of periodic breathing.
    Type: Grant
    Filed: May 17, 2007
    Date of Patent: September 28, 2010
    Assignee: Widemed Ltd.
    Inventors: Daniel Reisfeld, Hila Sberro
  • DETECTION OF HEART FAILURE USING A PHOTOPLETHYSMOGRAPH
    Publication number: 20070213621
    Abstract: A method for diagnosis includes receiving a signal associated with blood oxygen saturation of a patient during sleep. The signal is filtered so as to eliminate signal components at frequencies equal to and greater than a respiratory frequency of the patient. The filtered signal is processed to detect a pattern corresponding to multiple cycles of periodic breathing.
    Type: Application
    Filed: May 17, 2007
    Publication date: September 13, 2007
    Applicant: WIDEMED LTD.
    Inventors: Daniel Reisfeld, Hila Sberro