Patents by Inventor Hilary A. Coller

Hilary A. Coller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INDUCING APOPTOSIS IN QUIESCENT CELLS
    Publication number: 20130064815
    Abstract: Compositions comprising an autophagy inhibitor and at least one of an NADPH modulator or a glutathione inhibitor are provided. Methods of inhibiting or killing a quiescent cell are provided. Methods of treating cancer are provided. Methods of identifying compositions that inhibit or kill quiescent cells are provided. Methods of identifying compositions that inhibit or kill quiescent cells are provided. Methods of inducing apoptosis are provided. Methods of sensitizing quiescent cells to proteasome inhibitors are provided.
    Type: Application
    Filed: September 12, 2012
    Publication date: March 14, 2013
    Applicant: THE TRUSTEES OF PRINCETON UNIVERSITY
    Inventor: Hilary Coller
  • Methods for predicting chemosensitivity or chemoresistance
    Patent number: 7324926
    Abstract: Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression. Methods, computer systems and apparatus for classifying or predicting whether a sample is treatment sensitive (e.g., chemosensitive) or treatment resistant (e.g., chemoresistant) are also provided. Classification occurs based on analysis of gene expression data from samples that have been subjected to one or more compounds.
    Type: Grant
    Filed: October 1, 2001
    Date of Patent: January 29, 2008
    Assignees: Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Inc.
    Inventors: Pablo Tamayo, Jane E. Staunton, Donna K. Slonim, Hilary A. Coller, Todd R. Golub, Eric S. Lander, Jill P. Mesirov
  • Methods for predicting chemosensitivity or chemoresistance
    Publication number: 20030073083
    Abstract: Methods and apparatus for classifying or predicting the classes for samples based on gene expression are described. Also described are methods and apparatus for ascertaining or discovering new, previously unknown classes based on gene expression. Methods, computer systems and apparatus for classifying or predicting whether a sample is treatment sensitive (e.g., chemosensitive) or treatment resistant (e.g., chemoresistant) are also provided. Classification occurs based on analysis of gene expression data from samples that have been subjected to one or more compounds.
    Type: Application
    Filed: October 1, 2001
    Publication date: April 17, 2003
    Inventors: Pablo Tamayo, Jane E. Staunton, Donna K. Slonim, Hilary A. Coller, Todd R. Golub, Eric S. Lander, Jill P. Mesirov
  • Methods for defining MYC target genes and uses thereof
    Publication number: 20010049393
    Abstract: Identification of MYC target genes whose expression is either induced or repressed by c-myc induction in human fibroblasts is disclosed. Also disclosed are methods of inducing or repressing expression of MYC target genes.
    Type: Application
    Filed: December 7, 2000
    Publication date: December 6, 2001
    Applicant: Whitehead Institute for Biomedical Research
    Inventors: Hilary A. Coller, Todd R. Golub, Carla Grandori, Pablo Tamayo, Trenton Colbert, Robert Eisenman