Patents by Inventor Hilary Koprowski

Hilary Koprowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9574206
    Abstract: The present invention relates to a genetically modified plant having an increased amount of oil in its green biomass as compared to the oil in the green biomass of its non-genetically modified counterpart. The plants may be used for producing bio-fuels such as biodiesel fuel.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: February 21, 2017
    Assignees: Biotechnology Foundation, Inc., Thomas Jefferson University
    Inventors: Hilary Koprowski, Vyacheslav Andrianov, Mykola Borysyuk
  • Patent number: 8847010
    Abstract: The present invention relates to a genetically modified plant having an increased amount of oil in its green biomass as compared to the oil in the green biomass of its non-genetically modified counterpart. The plants may be used for producing bio-fuels such as biodiesel fuel.
    Type: Grant
    Filed: June 12, 2008
    Date of Patent: September 30, 2014
    Assignees: Biotechnology Foundation, Inc., Thomas Jefferson University
    Inventors: Hilary Koprowski, Vyacheslav Andrianov, Mykola Borsyuk
  • Publication number: 20120174264
    Abstract: Methods of in vitro propagation of plants of the genus Eriodictyon are described, including, in particular embodiments, plants of the species E. californicum, E. trichocalyx and E. sessilifolium. Methods of producing transgenic plants of the genus Eriodictyon are also described, along with methods of producing recombinant proteins in such plants. Compositions and methods for administering recombinant proteins produced in these plants are also described.
    Type: Application
    Filed: March 8, 2012
    Publication date: July 5, 2012
    Inventors: Hilary Koprowski, Natalia Pogrebnyak, Maxim Golovkin
  • Patent number: 8148609
    Abstract: Methods of in vitro propagation of plants of the genus Eriodictyon are described, including, in particular embodiments, plants of the species E. californicum, E. trichocalyx and E. sessilifolium. Methods of producing transgenic plants of the genus Eriodictyon are also described, along with methods of producing recombinant proteins in such plants. Compositions and methods for administering recombinant proteins produced in these plants are also described.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: April 3, 2012
    Inventors: Hilary Koprowski, Natalia Pogrebnyak, Maxim Golovkin
  • Publication number: 20100184130
    Abstract: The present invention relates to a genetically modified plant having an increased amount of oil in its green biomass as compared to the oil in the green biomass of its non-genetically modified counterpart. The plants may be used for producing bio-fuels such as biodiesel fuel.
    Type: Application
    Filed: June 12, 2008
    Publication date: July 22, 2010
    Inventors: Hilary Koprowski, Vyacheslav Andrianov, Mykola Borsyuk
  • Publication number: 20100009913
    Abstract: Methods of in vitro propagation of plants of the genus Eriodictyon are described, including, in particular embodiments, plants of the species E. californicum, E. trichocalyx and E. sessilifolium. Methods of producing transgenic plants of the genus Eriodictyon are also described, along with methods of producing recombinant proteins in such plants. Compositions and methods for administering recombinant proteins produced in these plants are also described.
    Type: Application
    Filed: June 19, 2009
    Publication date: January 14, 2010
    Inventors: Hilary Koprowski, Natalia Pogrebnyak, Maxim Golovkin
  • Publication number: 20100003269
    Abstract: The present invention relates to a method for the generation of transgenic Brassica oleracea plants, in particular transgenic Cruciferae (also known as Brassicaceae) plants. The present invention also provides a method for the production of heterologous proteins using a Cruciferae-based plant system, for example pharmaceutical and/or recombinant proteins. In particular the invention also relates to a method for the production of transgenic collard and cauliflower, and to the large scale production of pharmaceutical and/or therapeutic production, such as production of Cruciferae-based vaccine production.
    Type: Application
    Filed: June 28, 2007
    Publication date: January 7, 2010
    Applicant: THOMAS JEFFERSON UNIVERSITY
    Inventors: Hilary Koprowski, Maxim Golovkin, Slava Andrianov, Sergei Spitsin, Natalia Pogrebnyak
  • Publication number: 20090041776
    Abstract: The invention as described herein provides compositions and methods for cancer immunotherapy and cancer detection. In particular, the invention discloses plant-derived human monoclonal antibodies that bind human carcinoma antigens in cancer cell lines.
    Type: Application
    Filed: April 23, 2008
    Publication date: February 12, 2009
    Applicants: Biotechnology Foundation, Inc., The Chancellor, Masters and Scholars of the University of Oxford, University of Oxford
    Inventors: Hilary Koprowski, Kisung Ko, Pauline Rudd, Yoram Tekoah, Raymond Dwek
  • Publication number: 20060134099
    Abstract: Human rabies monoclonal antibodies (rabies MAbP) comprising rabies human MAb S057 heavy chain and light chain subunits are expressed and assembled in plants under the control of two strong constitutive promoters. Additionally, regulatory control elements such as alfalfa mosaic virus untranslated leader sequence and Lys-Asp-Glu-Leu (KDEL) endoplasmic reticulum retention signal were linked at the N- and C-terminus of the heavy chain of human rabies MAbP, respectively to regulate expression of the rabies MAbP. Rabies MAbP was as effective at neutralizing the activity of the rabies virus as the mammalian-derived antibody (MAbM) or human rabies immunoglobulin (HRIG).
    Type: Application
    Filed: June 2, 2004
    Publication date: June 22, 2006
    Applicants: BIOTECHNOLOGY FOUNDATION, INC., UNIVERSITY OF OXFPRD
    Inventors: Hilary Koprowski, Kisung Ko, Pauline Rudd, Raymond Dwek, Yoram Tekoah
  • Publication number: 20050229275
    Abstract: The present invention discloses novel methods for producing foreign polypeptides in a host plant using recombinant viruses through functional complementation systems. The methods involve constructing suitable recombinant viral vectors that are capable of systemic infection and infecting the host plants with one or more recombinant viral vectors. The methods are also directed to infecting a host plant that is transgenic for expressing replicase genes of a virus, wherein the transgenic plant expressing a virus replicase genes complements the virus replicase function. The invention also discloses a method for producing a full-length antibody in a host plant using viral vectors.
    Type: Application
    Filed: December 7, 2004
    Publication date: October 13, 2005
    Applicant: Thomas Jefferson University
    Inventors: Hilary Koprowski, Vidadi Yusibov
  • Publication number: 20050138692
    Abstract: The invention as described herein provides compositions and methods for cancer immunotherapy and cancer detection. In particular, the invention discloses plant-derived human monoclonal antibodies that bind human carcinoma antigens in cancer cell lines.
    Type: Application
    Filed: June 2, 2004
    Publication date: June 23, 2005
    Applicants: Biotechnology Foundation, Inc., The Chancellor, Masters and Scholars of the University of Oxford, University of Oxford
    Inventors: Hilary Koprowski, Kisung Ko, Pauline Rudd, Yoram Tekoah, Raymond Dwek
  • Patent number: 6645498
    Abstract: The present invention describes novel soluble variants of type I membrane protein GA733-2 and methods of making and using them. In addition, the present invention describes a method of converting type I membrane proteins into secretory proteins which may be used for active immunotherapy against carcinomas and as reagents in the detection of GA733-2 expression on tumor cells.
    Type: Grant
    Filed: March 30, 1995
    Date of Patent: November 11, 2003
    Assignee: The Wistar Institute of Anatomy and Biology
    Inventors: Alban J. Linnenbach, Hilary Koprowski, Dorothee Herlyn
  • Publication number: 20030103935
    Abstract: The present invention describes novel soluble variants of type I membrane protein GA733-2 and methods of making and using them. In addition, the present invention describes a method of converting type I membrane proteins into secretory proteins which may be used for active immunotherapy against carcinomas and as reagents in the detection of GA733-2 expression on tumor cells.
    Type: Application
    Filed: November 19, 2002
    Publication date: June 5, 2003
    Applicant: The Wistar Institute of Anatomy and Biology
    Inventors: Alban J. Linnenbach, Hilary Koprowski, Dorothee Herlyn
  • Patent number: 6448070
    Abstract: A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such as a human. The plant virus capsid protein is that of an alfalfa mosaic virus (AlMV) or ilarvirus.
    Type: Grant
    Filed: February 25, 1999
    Date of Patent: September 10, 2002
    Assignee: Thomas Jefferson University
    Inventors: Hilary Koprowski, Vidadi Yusibov, Douglas Craig Hooper, Anna Modelska
  • Patent number: 6436648
    Abstract: Chimeric viral proteins and nucleic acid constructs that code for them and are useful as therapeutic agents are disclosed.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: August 20, 2002
    Assignee: Thomas Jefferson University
    Inventors: Alagarsamy Srinivisan, Hilary Koprowski
  • Publication number: 20020052478
    Abstract: Chimeric viral proteins and nucleic acid constructs that code for them and are useful as therapeutic agents are disclosed.
    Type: Application
    Filed: March 26, 2001
    Publication date: May 2, 2002
    Inventors: Alagarsamy Srinivisan, Hilary Koprowski
  • Patent number: 6355621
    Abstract: Oligodeoxynucleotides complementary to genomic RNA of a negative-stranded nonsegmented RNA virus are provided. Methods of inhibiting infection of cells by a negative-stranded nonsegmented RNA virus and treating animals infected with a negative-stranded nonsegmented RNA virus using these oligodeoxynucleotides are also provided.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: March 12, 2002
    Assignee: Thomas Jefferson University
    Inventors: Zhen Fang Fu, Eric Wickstrom, Bernhard Dietzschold, Hilary Koprowski
  • Patent number: 6271354
    Abstract: Chimeric viral proteins and nucleic acid constructs that code for them and are useful as therapeutic agents.
    Type: Grant
    Filed: April 2, 1998
    Date of Patent: August 7, 2001
    Assignee: Thomas Jefferson University
    Inventors: Alagarsamy Srinivisan, Hilary Koprowski
  • Patent number: 6129921
    Abstract: Methods of enhancing an antigen-induced immune response through use of a ribonucleocapsid complex are provided. Composition containing a ribonucleocapsid complex and an antigen which are capable of enhancing the immune response to the antigen are also provided.
    Type: Grant
    Filed: December 5, 1995
    Date of Patent: October 10, 2000
    Assignee: Thomas Jefferson University
    Inventors: Douglas Craig Hooper, Bernhard Dietzschold, Hilary Koprowski
  • Patent number: 6042832
    Abstract: A fusion capsid protein comprising a plant virus capsid protein fused to an antigenic polypeptide is used as a molecule for presentation of that polypeptide to the immune system of an animal such as a human. The plant virus capsid protein is that of an alfalfa mosaic virus (AlMV) or ilarvirus.
    Type: Grant
    Filed: August 28, 1996
    Date of Patent: March 28, 2000
    Assignee: Thomas Jefferson University
    Inventors: Hilary Koprowski, Vidadi Yusibov, Douglas Craig Hooper, Anna Modelska