Patents by Inventor Hilary P. Francis

Hilary P. Francis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antithrombotic substituted cycloalkano (B) dihydroindole sulphonamides
    Patent number: 5374647
    Abstract: Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0,1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine,with the proviso, that in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.
    Type: Grant
    Filed: April 5, 1993
    Date of Patent: December 20, 1994
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Bohagen, Ulrich Muller, Ulrich Rosentreter, Erwin Bischoff, Volker-Bernd Fiedler, Elisabeth Perzborn, Joachim Hutter, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis, Marie G. McKenniff
  • Antithrombotic iso- and heterocyclic phenylsulphonamides
    Patent number: 5264458
    Abstract: Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: November 23, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Franz-Peter Hoever, Elisabeth Perzborn, Volker-Bernd Fiedler, Peter Norman, Hilary P. Francis, Marie G. McKenniff
  • Substituted alkenoic acid and its derivatives
    Patent number: 5246966
    Abstract: The new substituted alkenoic acid derivatives can be prepared by reacting the appropriate aldehyde with a phosphonium compound. The compounds have leukotriene antagonistic properties and can be incorporated into pharmaceutical compositions.
    Type: Grant
    Filed: December 30, 1991
    Date of Patent: September 21, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinrich Meier, John E. B. Ransohoff, Trevor S. Abram, Peter Norman, Tudhope Stephen R., Phillip J. Gardiner, Nigel J. Cuthbert, Hilary P. Francis
  • Cycloalkano(b)dihydroindoles and -indolesulphonamides substituted by heterocycles
    Patent number: 5204374
    Abstract: New cycloalkano[b]dihydroindoles and -indolesulphonamides, substituted by heterocycles, of the formula (I) ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different andrepresent hydrogen, nitro, cyano, halogen, trifluoromethyl, carboxyl, hydroxyl or trifluoromethoxy, orrepresent a group of the formula --S(O).sub.w R.sup.5, in whichR.sup.5 denotes alkyl or optionally substituted aryl,w denotes the number 0, 1 or 2, orrepresents alkoxy or alkoxycarbonyl, or benzyloxy, orrepresents a group of the formula --NR.sup.6 R.sup.7, in whichR.sup.6 and R.sup.7 are identical or different anddenote hydrogen, alkyl or acyl ordenote aryl, ordenote a group of the formula --S(O).sub.w R.sup.5, in which R.sup.
    Type: Grant
    Filed: April 3, 1991
    Date of Patent: April 20, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich E. Muller, Ulrich Rosentreter, Ulrich Niewohner, Elisabeth Perzborn, Erwin Bischoff, Hans-Georg Dellweg, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis
  • Antithrombotic iso- and heterocyclic phenylsulphonamides
    Patent number: 5191092
    Abstract: Iso- and heterocyclic phenylsulphonamides can be prepared by reaction of corresponding iso- and heterocyclic amines with phenylsulphonic acid derivatives. The iso- and heterocyclic phenylsulphonamides have thrombocyte aggregation-inhibiting and thromboxane A.sub.2 antagonist action and can be used in medicaments.
    Type: Grant
    Filed: September 26, 1990
    Date of Patent: March 2, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventors: Ulrich Niewohner, Franz-Peter Hoever, Elisabeth Perzborn, Volker-Bernd Fiedler, Peter Norma, Hilary P. Francis, Marie G. McKenniff
  • Antithrombotic substituted cycloalkano(b)dihydroindole- and -indole-sulphonamides
    Patent number: 5096897
    Abstract: Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1, 2, 3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: March 17, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Muller, Ulrich Rosentreter, Erwin Bischoff, Volker-Bernd Fiedler, Elisabeth Perzborn, Joachim Hutter, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis, Marie G. McKenniff
  • Antithrombotic substituted cycloalkano(B)dihydroindole- and -indole-sulphonamides and use
    Patent number: 5039670
    Abstract: Substituted antithrombotic substituted cycloalkano[b]-dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0, 1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine, with the proviso that, in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group,or a salt thereof.
    Type: Grant
    Filed: October 17, 1990
    Date of Patent: August 13, 1991
    Assignee: Bayer Aktiengesellschaft
    Inventors: Horst Boshagen, Ulrich Muller, Ulrich Rosentreter, Erwin Bischoff, Volker-Bernd Fiedler, Elisabeth Perzborn, Joachim Hutter, Peter Norman, Nigel J. Cuthbert, Hilary P. Francis, Marie G. McKenniff