Patents by Inventor Hilda M. L. Buyoli

Hilda M. L. Buyoli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assays and kits incorporating nucleic acid probes containing improved molecular switch
    Patent number: 5312728
    Abstract: A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful for selectively generating a detectable signal if the probe is hybridized to a target; also, assays and kits utilizing such probes.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: May 17, 1994
    Assignees: Public Health Research Institute of the City of New York, Inc., The Salk Institute for Biological Studies
    Inventors: Paul M. Lizardi, Fred R. Kramer, Sanjay Tyagi, Cesar E. Guerra, Hilda M. L. Buyoli, Barbara C. Chu, Gerald F. Joyce, Leslie E. Orgel
  • Nucleic acid process containing improved molecular switch
    Patent number: 5118801
    Abstract: A probe for the detection of a nucleic acid target sequence containing a molecular switch comprising three essential elements: a probe sequence of 20-60 nucleotides surrounded by switch sequences of 10-40 nucleotides which are complementary to each other, wherein the state of the switch is useful for selectively generating a detectable signal if the probe is hybridized to a target; also, assays and kits utilizing such probes.
    Type: Grant
    Filed: September 30, 1988
    Date of Patent: June 2, 1992
    Assignees: The Public Health Research Institute, The Salk Instiute for Biological Studies
    Inventors: Paul M. Lizardi, Fred R. Kramer, Sanjay Tyagi, Cesar E. Guerra, Hilda M. L. Buyoli