Patents by Inventor Hilde Stals

Hilde Stals has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of variable domains
    Patent number: 9150640
    Abstract: The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provided and polypeptides comprising one or more variable domains obtainable by the methods of the present invention, as well as compounds that comprise such variable domains and/or polypeptides coupled to one or more groups, residues or moieties.
    Type: Grant
    Filed: July 9, 2010
    Date of Patent: October 6, 2015
    Assignee: Ablynx N.V.
    Inventors: Hilde Stals, Veronique De Brabandere, Peter Schotte
  • METHOD FOR THE PRODUCTION OF VARIABLE DOMAINS
    Publication number: 20150023963
    Abstract: The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provided and polypeptides comprising one or more variable domains obtainable by the methods of the present invention, as well as compounds that comprise such variable domains and/or polypeptides coupled to one or more groups, residues or moieties.
    Type: Application
    Filed: June 20, 2014
    Publication date: January 22, 2015
    Applicant: Ablynx N.V.
    Inventors: Hilde Stals, Veronique De Brabandere, Peter Schotte
  • METHOD FOR THE PRODUCTION OF VARIABLE DOMAINS
    Publication number: 20120141460
    Abstract: The present invention provides methods for the expression and/or production of variable domains with a C-terminal extension that can be used for coupling of the variable domain to one or more further groups, residues or moieties. In the method of the invention a yield of at least 80% of variable domains with a cysteine containing C-terminal extension is obtained. Also variable domains are provided and polypeptides comprising one or more variable domains obtainable by the methods of the present invention, as well as compounds that comprise such variable domains and/or polypeptides coupled to one or more groups, residues or moieties.
    Type: Application
    Filed: July 9, 2010
    Publication date: June 7, 2012
    Applicant: Ablynx N.V.
    Inventors: Hilde Stals, Veronique De Brabandere, Peter Schotte
  • IMMUNOGLOBULIN SINGLE VARIABLE DOMAIN DIRECTED AGAINST HUMAN CXCR4 AND OTHER CELL ASSOCIATED PROTEINS AND METHODS TO GENERATE THEM
    Publication number: 20110117113
    Abstract: The invention relates to immunoglobulin single variable domains directed against specific human CXCR4 epitopes (herein also referred to interchangeably as “compounds of the invention”, “amino acid sequences of the invention”, or “building blocks of the invention”) and polypeptides comprising them (herein also referred to as “polypeptides of the invention”, “compounds of the invention”, or “constructs of the invention”).
    Type: Application
    Filed: October 4, 2010
    Publication date: May 19, 2011
    Inventors: Gerald Beste, Stephanie Staelens, Peter Vanlandschoot, Maria Gonzalez Pajuelo, Hilde Adi Pierrette Revets, Peter Schotte, Hilde Stals, Ann Brige, Maarten Dewilde, Catelijne Stortelers