Patents by Inventor Hildegard Kuss

Hildegard Kuss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 7-azaindoles and the use thereof as therapeutic agents
    Patent number: 7947705
    Abstract: The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Grant
    Filed: March 6, 2007
    Date of Patent: May 24, 2011
    Assignee: Biotie Therapies GmbH
    Inventors: Norbert Höfgen, Hildegard Kuss, Matthias Olbrich, Ute Egerland, Chris Rundfeldt, Karin Steinike, Rudolf Schindler
  • 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
    Patent number: 7683074
    Abstract: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds and methods of treating arthritis and other conditions with the compounds are also provided.
    Type: Grant
    Filed: March 10, 2008
    Date of Patent: March 23, 2010
    Assignee: Biotie Therapies GmbH
    Inventors: Norbert Höfgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • Combination of loteprednol and ?-adrenoceptor agonists
    Patent number: 7521438
    Abstract: The invention relates to a novel combination of a soft steroid, in particular loteprednol, and at least one ?2 adrenoceptor agonist for the simultaneous, sequential or separate treatment of allergies and/or airway disorders, medicaments comprising the combination, processes for the production of such medicaments and the use of the novel combination for the production of medicaments for the simultaneous, sequential or separate treatment of allergies and/or airway disorders.
    Type: Grant
    Filed: September 26, 2000
    Date of Patent: April 21, 2009
    Assignee: MEDA Pharma GmbH & Co. KG
    Inventors: Istvan Szelenyi, Hildegard Kuss, Sabine Heer, Juergen Engel
  • 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
    Patent number: 7419987
    Abstract: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds are also provided.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: September 2, 2008
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • 7-Azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
    Publication number: 20080207680
    Abstract: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds and methods of treating arthritis and other conditions with the compounds are also provided.
    Type: Application
    Filed: March 10, 2008
    Publication date: August 28, 2008
    Inventors: Norbert Hofgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • Use of the non-opiate analgesic drug flupirtine for the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowel syndrome
    Patent number: 7309713
    Abstract: The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction including bladder instability and other related diseases as described below including urinary flow problems, urgency and incontinence as a result of prostate hyperplasia (BPH) and to the prevention, reversal and medical treatment of irritable bowl syndrome (IBS) with special focus on the diarrhea-predominant and mixed diarrhea-constipation type IBS, both in human beings and animals.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: December 18, 2007
    Assignee: Elbion AG
    Inventors: Chris Rundfeldt, Hildegard Kuss, Regina Draheim, Katrin Bernoester
  • 7-Azaindoles and the use thereof as therapeutic agents
    Publication number: 20070161671
    Abstract: The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Application
    Filed: March 6, 2007
    Publication date: July 12, 2007
    Inventors: Nobert Hofgen, Hildegard Kuss, Matthias Olbrich, Ute Egerland, Chris Rundfeldt, Karin Steinike, Rudolf Schindler
  • 7-azaindoles and the use thereof as therapeutic agents
    Patent number: 7211583
    Abstract: The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: May 1, 2007
    Assignee: Elbion AG
    Inventors: Nobert Höfgen, Hildegard Kuss, Matthias Olbrich, Ute Egerland, Chris Rundfeldt, Karin Steinike, Rudolf Schindler
  • Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
    Publication number: 20070093531
    Abstract: The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lympho-cytes).
    Type: Application
    Filed: November 30, 2006
    Publication date: April 26, 2007
    Inventors: Norbert Hofgen, Hildegard Kuss, Ute Egerland, Chris Rundfeldt, Helge Hartenhauer, Antje Gasparic
  • 7-azaindoles, use thereof as phosphodiesterase 4 inhibitors and method for producing the same
    Patent number: 7169787
    Abstract: The invention relates to new 7-azaindoles, their use as inhibitors of phosphodiesterase 4 and to methods for their synthesis.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: January 30, 2007
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • Hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
    Patent number: 7166637
    Abstract: The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lymphocytes).
    Type: Grant
    Filed: November 13, 2003
    Date of Patent: January 23, 2007
    Assignee: Elbion AG
    Inventors: Norbert Höfgen, Hildegard Kuss, Ute Egerland, Chris Rundfeldt, Helge Hartenhauer, Antje Gasparic
  • 7-azaindoles, their use as inhibitors of phosphodiesterase 4, and a method for synthesizing them
    Publication number: 20060258700
    Abstract: 7-azaindoles inhibit phosphodiesterase 4 (PDE4). Methods for preparing these compounds are also provided.
    Type: Application
    Filed: January 10, 2006
    Publication date: November 16, 2006
    Inventors: Norbert Hofgen, Ute Egerland, Thomas Kronbach, Degenhard Marx, Stefan Szelenyi, Hildegard Kuss, Emmanuel Polymeropoulos
  • Use of the non-opiate analgesic drug flupirtine of the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowl syndrome
    Publication number: 20060173052
    Abstract: The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction including bladder instability and other related diseases as described below including urinary flow problems, urgency and incontinence as a result of prostate hyperplasia (BPH) and to the prevention, reversal and medical treatment of irritable bowl syndrome (IBS) with special focus on the diarrhea-predominant and mixed diarrhea-constipation type IBS, both in human beings and animals.
    Type: Application
    Filed: January 20, 2006
    Publication date: August 3, 2006
    Inventors: Chris Rundfeldt, Hildegard Kuss, Regina Draheim
  • 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents
    Patent number: 7067536
    Abstract: The invention relates to substituted 4-, 6- or 7-hydroxyindoles with N-oxide groups, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: June 27, 2006
    Assignee: Elbion AG
    Inventors: Nobert Hofgen, Hildegard Kuss, Karin Steinike, Ute Egerland, Chris Rundfeldt
  • 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents
    Publication number: 20060128758
    Abstract: The invention relates to substituted 4-, 6- or 7-hydroxyindoles with N-oxide groups, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Application
    Filed: January 30, 2006
    Publication date: June 15, 2006
    Inventors: Nobert Hofgen, Hildegard Kuss, Karin Steinike, Ute Egerland, Chris Rundfeldt
  • 5-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents
    Publication number: 20040266760
    Abstract: The invention relates to substituted 5-hydroxyindoles with N-oxide groups, processes for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Application
    Filed: April 14, 2004
    Publication date: December 30, 2004
    Inventors: Nobert Hofgen, Hildegard Kuss, Karin Steinike, Ute Egerland, Chris Rundfeldt, Thomas Pfeifer
  • 4-,6- or 7-hydroxyindoles with N-oxide groups and the use thereof as therapeutic agents
    Publication number: 20040242643
    Abstract: The invention relates to substituted 4-,6- or 7-hydroxyindoles with N-oxide groups, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Application
    Filed: April 16, 2004
    Publication date: December 2, 2004
    Inventors: Nobert Hofgen, Hildegard Kuss, Karin Steinike, Ute Egerland, Chris Rundfeldt
  • 7-azaindoles and the use thereof as therapeutic agents
    Publication number: 20040224971
    Abstract: The invention relates to substituted 7-azaindoles, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.
    Type: Application
    Filed: April 16, 2004
    Publication date: November 11, 2004
    Inventors: Nobert Hofgen, Hildegard Kuss, Matthias Olbrich, Ute Egerland, Chris Rundfeldt, Karin Steinike, Rudolf Schindler
  • Novel hydroxyindoles, their use as inhibitors of phosphodiesterase 4, and processes for preparing them
    Publication number: 20040147759
    Abstract: The invention relates to substituted 4- or/and 7-hydroxyindoles, to processes for preparing them, to pharmaceutical preparations which comprise these compounds and to the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active compounds for treating diseases which can be influenced by using the compounds according to the invention to inhibit phosphodiesterase 4 activity in immunocompetent cells (e.g. macrophages and lymphocytes).
    Type: Application
    Filed: November 13, 2003
    Publication date: July 29, 2004
    Inventors: Norbert Hofgen, Hildegard Kuss, Ute Egerland, Chris Rundfeldt, Helge Hartenhauer, Antje Gasparic
  • Hydroxyindoles, their use as inhibitors of phosphodiesterase 4 and process for their preparation
    Patent number: RE38624
    Abstract: The invention relates to new hydroxyindoles of the Formula, their use as inhibitors of phosphodiesterase 4 and processes for their preparation.
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: October 12, 2004
    Assignee: Elbion AG
    Inventors: Norbert Hofgen, Ute Egerland, Hildegard Kuss, Degenhard Marx, Stefan Szelenyi, Thomas Kronbach, Emmanuel Polymeropoulos, Sabine Heer