Abstract: Systems and methods for monitoring blood supply to the brain of an individual are presented; the system comprising a sensing unit configured to be placed in a vicinity of at least one blood vessel and operable to collect over time, from the at least one blood vessel, measured data indicative of one or more hemodynamic parameters; and a control and processing unit in communication with the sensing unit, the control and processing unit being operable to receive and analyze said measured data, determine hemodynamic data comprising said one or more hemodynamic parameters, analyze said hemodynamic data and, upon detecting a predetermined change over time in the hemodynamic data, generate output data indicative of a blood supply condition to the brain of the individual.