Patents by Inventor Himani Dhotre

Himani Dhotre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A Process for the Preparation of Methylene Blue
    Publication number: 20230138553
    Abstract: Provided herein is a process for preparation of 3,7-bis-(dimethylamino)-phenothian-5-ium chloride: Formula (I). The said process comprises preparing 3,7-dibromophenothiazin-5-ium bromide wet Crude(III) from phenothiazine (II) along promoter, catalyst and brominating agent in presence of organic solvent; preparing 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide (IV) from 3,7-dibromophenothiazin-5-ium bromide; preparing 3,7-bis (Dimethylamino)-phenothiazin-5-ium chloride from 3,7-bis-(dimethylamino)-phenothiazin-5-ium bromide and subsequently purifying and removing metal content through metal scavenger from 3,7-bis-(dimethylamino)-phenothiazin-5-ium chloride (I). The present process eliminates the additional step of ion exchange column in the reaction and provides 99 to 99.5 percentage of product purity.
    Type: Application
    Filed: February 27, 2021
    Publication date: May 4, 2023
    Inventors: Janmejay Rajnikant Vyas, Himani Dhotre, Denish H. Shah, Krunal Parikh
  • Process for the preparation of indigo carmine
    Patent number: 10738192
    Abstract: The present invention relates to an improved process for preparation of Indigo carmine of Formula (I), in high purity, more than 99.5%.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: August 11, 2020
    Assignee: DISHMAN CARBOGEN AMCIS LIMITED
    Inventors: Janmejay Rajnikant Vyas, Himani Dhotre, Narasimha Sarma, Dilip N. Patel, Piyush Sangani, Arpan Kiritbhai Shah, Babulal R. Patel, Devang Wadia
  • Process for the preparation of isosulfan blue
    Patent number: 10501629
    Abstract: The present invention relates to process for preparation of Isosulfan blue (Formula I) substantially free from desethyl impurity.
    Type: Grant
    Filed: October 1, 2016
    Date of Patent: December 10, 2019
    Assignee: DISHMAN CARBOGEN AMCIS LIMITED
    Inventors: Janmejay Rajnikant Vyas, Yashbir Singh, Chiragkumar Chandrakantbhai Patel, Sandip Babanrao Pawar, Himani Dhotre, K. Narasimha Sarma, Dilip N. Patel, Renish Ghetiya, Babulal R. Patel, Sarika P. Deshmukh, Girish Mavada
  • Process for the preparation of indocyanine green
    Patent number: 10287436
    Abstract: The present invention involves an improved process for the preparation of Indocyanine green of Formula (I) having high purity of about 99%, wherein the process comprises steps of reacting 1,1,2-trimethyl-1H-benzo[e]indole with 1,4-butane sulfone in boiling solvent to give 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate. Followed by reacting 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula (IV) and N-phenyl-N-((1E,3E,5E)-5-(phenylimino)penta-1,3-dienyl)acetamide of formula (V) in presence of sodium acetate and alcohol; and extracting the title compound formula (I) with an ester solvent.
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: May 14, 2019
    Assignee: DISHMAN CARBOGEN AMCIS LIMITED
    Inventors: Janmejay Rajnikant Vyas, Himani Dhotre, Narasimha Sarma, Babulal R. Patel, Dinesh Kumar Sharma, Dilip N. Patel, Ashish A. Soni
  • AN IMPROVED PROCESS FOR THE PREPARATION OF ISOSULFAN BLUE
    Publication number: 20190010330
    Abstract: The present invention relates to process for preparation of Isosulfan blue (Formula I) substantially free from desethyl impurity.
    Type: Application
    Filed: October 1, 2016
    Publication date: January 10, 2019
    Applicant: DISHMAN PHARMACEUTICALS AND CHEMICALS LIMITED
    Inventors: Janmejay Rajnikant Vyas, Yashbir Singh, Chiragkumar Chandrakantbhai Patel, Sandip Babanrao Pawar, Himani Dhotre, K. Narasimha Sarma, Dilip N. Patel, Renish Ghetiya, Babulal R. Patel, Sarika P. Deshmukh, Girish Mavada
  • PROCESS FOR THE PREPARATION OF INDOCYANINE GREEN
    Publication number: 20180346728
    Abstract: The present invention involves an improved process for the preparation of Indocyanine green of Formula (I) having high purity of about 99%, wherein the process comprises steps of reacting 1,1,2-trimethyl-1H-benzo[e]indole with 1,4-butane sulfone in boiling solvent to give 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate. Followed by reacting 4-(1,1,2-trimethyl-1H-benzo[e]indolium-3-yl)butane-1-sulfonate of Formula (IV) and N-phenyl-N-((1E,3E,5E)-5-(phenylimino)penta-1,3-dienyl)acetamide of formula (V) in presence of sodium acetate and alcohol; and extracting the title compound formula (I) with an ester solvent.
    Type: Application
    Filed: November 29, 2016
    Publication date: December 6, 2018
    Applicant: DISHMAN PHARMACEUTICALS AND CHEMICALS LIMITED
    Inventors: Janmejay Rajnikant Vyas, Himani Dhotre, Narasimha Sarma, Babulal R. Patel, Dinesh Kumar Sharma, Dilip N. Patel, Ashish A. Soni
  • PROCESS FOR THE PREPARATION OF INDIGO CARMINE
    Publication number: 20180346727
    Abstract: The present invention relates to an improved process for preparation of Indigo carmine of Formula (I), in high purity, more than 99.5%.
    Type: Application
    Filed: November 25, 2016
    Publication date: December 6, 2018
    Applicant: DISHMAN PHARMACEUTICALS AND CHEMICALS LIMITED
    Inventors: Janmejay Rajnikant Vyas, Himani Dhotre, Narasimha Sarma, Dilip N. Patel, Piyush Sangani, Arpan Kiritbhai Shah, Babulal R. Patel, Devang Wadia