Abstract: Aspects of the present disclosure involve a transform domain regression convolutional neural network for image segmentation. Example embodiments include a system comprising a machine-readable storage medium storing instructions and computer-implemented methods for classifying one or more pixels in an image. The method may include analyzing the image to estimate one or more transform domain coefficients using a multi-layered function such as a convolutional neural network. The method may further include generating a segmented image by applying a change of basis transformation to the estimated one or more transform domain coefficients.