Abstract: Systems and methods are disclosed for restoring venous valve function. In some embodiments, for example, a system includes an implantable coil and a deployment device therefor. The implantable coil has a non-coiled configuration in a first state and a coiled configuration in a second state configured to compress incompetent valves. The deployment device includes a handle, an outer sheath, a needle, and a mandrel. The handle includes a first actuator and a second actuator. The outer sheath includes a side opening proximate a distal end. The needle is operatively coupled to the first actuator. The mandrel is operatively coupled to the second actuator. The mandrel is configured to push the implantable coil through a needle tip of the needle, which allows the implantable coil to transition from the first state within the deployment device to the second state outside of the deployment device such as around a vein.

Abstract: A guide wire is described for navigating body channels such as vessels. The guide wire can include an elongated member having a proximal portion and a distal portion, and a fluid passage to transport a fluid from the proximal portion to the distal portion. The distal portion of the elongated member can include a shape memory material with two way memory effect. The shape memory material can have a transition temperature less than a body temperature such that the distal portion has a first shape at the body temperature and a second shape different from the first shape at a temperature less than the transition temperature.

Abstract: A guide wire is described for navigating body channels such as vessels. The guide wire can include an elongated member having a proximal portion and a distal portion, and a fluid passage to transport a fluid from the proximal portion to the distal portion. The distal portion of the elongated member can include a shape memory material with two way memory effect. The shape memory material can have a transition temperature less than a body temperature such that the distal portion has a first shape at the body temperature and a second shape different from the first shape at a temperature less than the transition temperature.

Abstract: A guide wire is described for navigating body channels such as vessels. The guide wire can include an elongated member having a proximal portion and a distal portion, and a fluid passage to transport a fluid from the proximal portion to the distal portion. The distal portion of the elongated member can include a shape memory material with two way memory effect. The shape memory material can have a transition temperature less than a body temperature such that the distal portion has a first shape at the body temperature and a second shape different from the first shape at a temperature less than the transition temperature.