Patents by Inventor Himashinie DIYABALANAGE

Himashinie DIYABALANAGE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MONITORING AND ASSESSING DEACETYLASE ENZYME ACTIVITY
    Publication number: 20160138077
    Abstract: Disclosed herein are compounds and methods for detecting enzyme activity. In some embodiments, the enzyme is a deacetylase enzyme such as HDAC. The compound of the invention comprises a detectable label, a linker, and an enamide group. The compound can be enzymatically cleaved by the enzyme of interest to produce a nucleophilic fragment that includes the detectable label. Measurement of a signal generated by the detectable label can indicate enzyme activity. The compounds can be used as either in vivo or in vitro enzyme probes.
    Type: Application
    Filed: June 17, 2014
    Publication date: May 19, 2016
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Jacob HOOKER, Himashinie DIYABALANAGE