Patents by Inventor Hinanit Koltai

Hinanit Koltai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240165135
    Abstract: Compositions capable of reducing viability, inducing cell cycle arrest and/or reducing proliferation and/or migration of Glioblastoma multiforme (GMB) and ovarian cancer cells and methods of use thereof are provided. The compositions and uses thereof comprise phytocannabinoids.
    Type: Application
    Filed: October 4, 2023
    Publication date: May 23, 2024
    Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization
    Inventors: Hinanit KOLTAI, Nurit SHALEV, Hadar PEERI
  • Publication number: 20240041902
    Abstract: Compositions capable of reducing viability, initiating apoptosis, inducing cell cycle arrest and/or reducing migration of urothelial carcinoma cells and methods of use thereof are provided. The compositions and uses thereof comprise cannabinoids.
    Type: Application
    Filed: December 8, 2021
    Publication date: February 8, 2024
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Tel HaShomer Medical Research Infrastructure and Services Ltd.
    Inventors: Hinanit KOLTAI, Omer ANIS
  • Patent number: 11833131
    Abstract: A method of treating an inflammatory disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), wherein the fraction comprises cannabis derived active ingredients other than the THCA.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: December 5, 2023
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research, Mor Research Applications Ltd.
    Inventors: Hinanit Koltai, Yoram Kapulnik, Moran Mazuz, Timna Naftali
  • Publication number: 20230357712
    Abstract: A bio-ink comprising: (a) at least one polysaccharide; (b) at least one structural protein; and (c) fibrinogen, wherein the polysaccharide is selected from a group consisting of Sodium alginate Chitosan, Hyaluronic acid, Gellan gum, Dextran, Agarose, Poly(ethylene glycol), Pluronic and Carrageenan and the structural protein is selected from a group consisting of Gelatin, Collagen Vitronectin, Laminins and Fibronectin.
    Type: Application
    Filed: July 18, 2023
    Publication date: November 9, 2023
    Inventors: Hinanit KOLTAI, Nurit SHALEV
  • Publication number: 20230277564
    Abstract: Cannabinoidal compositions for the treatment of disease are provided. Accordingly, there is provided a method of treating a disease that can benefit from activating macrophages comprising administering to the subject a therapeutically effective amount of a composition comprising a cannabis derived fraction comprising phytocannabinoids, wherein said phytocannabinoids comprise at least 80% CBD and at least one of CBG and THCV. Also provided is a method of treating a cytokine storm comprising administering to the subject a therapeutically effective amount of a synthetic composition comprising phytocannabinoids, wherein said phytocannabinoids comprise at least 80% CBD and at least one of CBG and THCV.
    Type: Application
    Filed: April 4, 2023
    Publication date: September 7, 2023
    Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization
    Inventors: Hinanit KOLTAI, Nurit SHALEV, Dvora NAMDAR, Guy MECHREZ
  • Publication number: 20230263182
    Abstract: Described herein are a method of preparing a vegetable oil, comprising pressing a non-fruit tissue of a date palm offshoot, as well as a vegetable oil and a polysaccharide-containing fraction obtained by such a method. Further described herein is an oil comprising esters of fatty acids, wherein at least 10 weight percent of the fatty acids are linolelaidic acid, as well as compositions comprising a variety of ingredients, such as saccharides and amino acids, as characterized herein, and a method of isolating dihydrouracil from an oil and/or composition described herein. Further described is a method of preparing a vegetable oil, comprising pressing date kernel tissue.
    Type: Application
    Filed: September 1, 2021
    Publication date: August 24, 2023
    Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization
    Inventors: Hinanit KOLTAI, Dvora NAMDAR
  • Patent number: 11331301
    Abstract: A method of treating a malignant disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a first liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), and a therapeutically effective amount of a second liquid chromatography fraction of a cannabis extract comprising at least 75% cannabigerolic acid (CBGA), wherein the first liquid chromatography fraction comprises cannabis derived active ingredients other than the THCA, and the second liquid chromatography fraction comprises cannabis derived active ingredients other than the CBGA, thereby treating the malignant disease in the subject.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: May 17, 2022
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Mor Research Applications Ltd.
    Inventors: Hinanit Koltai, Yoram Kapulnik, Dvora Namdar, Moran Mazuz, Ido Laish, Timna Naftali
  • Publication number: 20220040144
    Abstract: Compositions and methods for the treatment of cutaneous T cell lymphoma (CTCL) are provided. The compositions and uses thereof comprise cannabinoids.
    Type: Application
    Filed: December 12, 2019
    Publication date: February 10, 2022
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.
    Inventors: Hinanit KOLTAI, Moran MAZUZ, Dvora NAMDAR, Iris AMITAY-LAISH, Emmilia HODAK, Lilach MOYAL ELCHARAR
  • Publication number: 20210290712
    Abstract: The present invention is directed to a composition consisting essentially of epigallocatechin, mannofuranose, ?-D-xylopyranose, gallic acid, palmitic acid, stearic acid, trans-catechin, cis-catechin, and an acceptable carrier, and a method of using same, such as for treating an inflammatory disease.
    Type: Application
    Filed: March 29, 2021
    Publication date: September 23, 2021
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Einav MAYZLISH GATI, Nasser AHMED, Shemer BEN ZION
  • Patent number: 10960035
    Abstract: Polar extracts of Erodium plants are disclosed as well as pharmaceutical compositions and cosmetic compositions comprising same. Uses of the polar extracts are also disclosed.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: March 30, 2021
    Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Voleaui Center), The Economic Company For The Development Of Ramat Hanegev Ltd.
    Inventors: Hinanit Koltai, Yoram Kapulnik, Marcelo Fridlender, Einav Mayzlish Gati, Nasser Ahmed, Shemer Ben Zion
  • Publication number: 20200222359
    Abstract: A method of treating an inflammatory disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), wherein the fraction comprises cannabis derived active ingredients other than the THCA.
    Type: Application
    Filed: March 5, 2018
    Publication date: July 16, 2020
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Moran MAZUZ, Timna NAFTALI
  • Publication number: 20200030282
    Abstract: A method of treating a malignant disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a first liquid chromatography fraction of a Cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), and a therapeutically effective amount of a second liquid chromatography fraction of a Cannabis extract comprising at least 75% cannabigerolic acid (CBGA), wherein the first liquid chromatography fraction comprises Cannabis derived active ingredients other than the THCA, and the second liquid chromatography fraction comprises Cannabis derived active ingredients other than the CBGA, thereby treating the malignant disease in the subject.
    Type: Application
    Filed: March 5, 2018
    Publication date: January 30, 2020
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Dvora NAMDAR, Moran MAZUZ, Ido LAISH, Timna NAFTALI
  • Publication number: 20190100731
    Abstract: A method of preparing an ex-vivo intestinal culture model is provided. The method comprising: (a) providing an intestinal tissue sample; (b) treating the intestinal tissue sample with a protease cleaving an extracellular matrix (ECM) component so as to break cell-cell contacts and obtain an intestinal preparation which maintains the overall intestinal tissue structure including villi and/or intestinal tissue layer orientation; (c) washing the preparation; and (d) culturing the preparation.
    Type: Application
    Filed: March 17, 2017
    Publication date: April 4, 2019
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat, Mor Research Applications Ltd.
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Timna NAFTALI
  • Patent number: 10208007
    Abstract: Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
    Type: Grant
    Filed: September 20, 2012
    Date of Patent: February 19, 2019
    Inventors: Yoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi
  • Publication number: 20180235213
    Abstract: A composition comprising at least one polymer, characterized by a surface energy having a value that ranges from 20 mJ/m2 to 60 mJ/m2, and an active agent (e.g., a plant hormone) is disclosed. A delivery device comprising the disclosed composition, adapted for installation on a part of a plant, is further disclosed. A method for applying a plant hormone to a plant is further disclosed.
    Type: Application
    Filed: May 11, 2016
    Publication date: August 23, 2018
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Smadar WEININGER
  • Publication number: 20180092954
    Abstract: Polar extracts of Erodium plants are disclosed as well as pharmaceutical compositions and cosmetic compositions comprising same. Uses of the polar extracts are also disclosed.
    Type: Application
    Filed: March 31, 2016
    Publication date: April 5, 2018
    Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Einav MAYZLISH GATI, Nasser AHMED, Shemer BEN ZION
  • Publication number: 20140323563
    Abstract: Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 30, 2014
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat, Georgetown University
    Inventors: Yoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi