Patents by Inventor Hinanit Koltai
Hinanit Koltai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240165135Abstract: Compositions capable of reducing viability, inducing cell cycle arrest and/or reducing proliferation and/or migration of Glioblastoma multiforme (GMB) and ovarian cancer cells and methods of use thereof are provided. The compositions and uses thereof comprise phytocannabinoids.Type: ApplicationFiled: October 4, 2023Publication date: May 23, 2024Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Hinanit KOLTAI, Nurit SHALEV, Hadar PEERI
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Publication number: 20240041902Abstract: Compositions capable of reducing viability, initiating apoptosis, inducing cell cycle arrest and/or reducing migration of urothelial carcinoma cells and methods of use thereof are provided. The compositions and uses thereof comprise cannabinoids.Type: ApplicationFiled: December 8, 2021Publication date: February 8, 2024Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Tel HaShomer Medical Research Infrastructure and Services Ltd.Inventors: Hinanit KOLTAI, Omer ANIS
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Patent number: 11833131Abstract: A method of treating an inflammatory disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), wherein the fraction comprises cannabis derived active ingredients other than the THCA.Type: GrantFiled: March 5, 2018Date of Patent: December 5, 2023Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research, Mor Research Applications Ltd.Inventors: Hinanit Koltai, Yoram Kapulnik, Moran Mazuz, Timna Naftali
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Publication number: 20230357712Abstract: A bio-ink comprising: (a) at least one polysaccharide; (b) at least one structural protein; and (c) fibrinogen, wherein the polysaccharide is selected from a group consisting of Sodium alginate Chitosan, Hyaluronic acid, Gellan gum, Dextran, Agarose, Poly(ethylene glycol), Pluronic and Carrageenan and the structural protein is selected from a group consisting of Gelatin, Collagen Vitronectin, Laminins and Fibronectin.Type: ApplicationFiled: July 18, 2023Publication date: November 9, 2023Inventors: Hinanit KOLTAI, Nurit SHALEV
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Publication number: 20230277564Abstract: Cannabinoidal compositions for the treatment of disease are provided. Accordingly, there is provided a method of treating a disease that can benefit from activating macrophages comprising administering to the subject a therapeutically effective amount of a composition comprising a cannabis derived fraction comprising phytocannabinoids, wherein said phytocannabinoids comprise at least 80% CBD and at least one of CBG and THCV. Also provided is a method of treating a cytokine storm comprising administering to the subject a therapeutically effective amount of a synthetic composition comprising phytocannabinoids, wherein said phytocannabinoids comprise at least 80% CBD and at least one of CBG and THCV.Type: ApplicationFiled: April 4, 2023Publication date: September 7, 2023Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Hinanit KOLTAI, Nurit SHALEV, Dvora NAMDAR, Guy MECHREZ
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Publication number: 20230263182Abstract: Described herein are a method of preparing a vegetable oil, comprising pressing a non-fruit tissue of a date palm offshoot, as well as a vegetable oil and a polysaccharide-containing fraction obtained by such a method. Further described herein is an oil comprising esters of fatty acids, wherein at least 10 weight percent of the fatty acids are linolelaidic acid, as well as compositions comprising a variety of ingredients, such as saccharides and amino acids, as characterized herein, and a method of isolating dihydrouracil from an oil and/or composition described herein. Further described is a method of preparing a vegetable oil, comprising pressing date kernel tissue.Type: ApplicationFiled: September 1, 2021Publication date: August 24, 2023Applicant: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research OrganizationInventors: Hinanit KOLTAI, Dvora NAMDAR
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Patent number: 11331301Abstract: A method of treating a malignant disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a first liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), and a therapeutically effective amount of a second liquid chromatography fraction of a cannabis extract comprising at least 75% cannabigerolic acid (CBGA), wherein the first liquid chromatography fraction comprises cannabis derived active ingredients other than the THCA, and the second liquid chromatography fraction comprises cannabis derived active ingredients other than the CBGA, thereby treating the malignant disease in the subject.Type: GrantFiled: March 5, 2018Date of Patent: May 17, 2022Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Volcani Center), Mor Research Applications Ltd.Inventors: Hinanit Koltai, Yoram Kapulnik, Dvora Namdar, Moran Mazuz, Ido Laish, Timna Naftali
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Publication number: 20220040144Abstract: Compositions and methods for the treatment of cutaneous T cell lymphoma (CTCL) are provided. The compositions and uses thereof comprise cannabinoids.Type: ApplicationFiled: December 12, 2019Publication date: February 10, 2022Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.Inventors: Hinanit KOLTAI, Moran MAZUZ, Dvora NAMDAR, Iris AMITAY-LAISH, Emmilia HODAK, Lilach MOYAL ELCHARAR
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Publication number: 20210290712Abstract: The present invention is directed to a composition consisting essentially of epigallocatechin, mannofuranose, ?-D-xylopyranose, gallic acid, palmitic acid, stearic acid, trans-catechin, cis-catechin, and an acceptable carrier, and a method of using same, such as for treating an inflammatory disease.Type: ApplicationFiled: March 29, 2021Publication date: September 23, 2021Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Einav MAYZLISH GATI, Nasser AHMED, Shemer BEN ZION
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Patent number: 10960035Abstract: Polar extracts of Erodium plants are disclosed as well as pharmaceutical compositions and cosmetic compositions comprising same. Uses of the polar extracts are also disclosed.Type: GrantFiled: March 31, 2016Date of Patent: March 30, 2021Assignees: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization (ARO) (Voleaui Center), The Economic Company For The Development Of Ramat Hanegev Ltd.Inventors: Hinanit Koltai, Yoram Kapulnik, Marcelo Fridlender, Einav Mayzlish Gati, Nasser Ahmed, Shemer Ben Zion
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Publication number: 20200222359Abstract: A method of treating an inflammatory disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a liquid chromatography fraction of a cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), wherein the fraction comprises cannabis derived active ingredients other than the THCA.Type: ApplicationFiled: March 5, 2018Publication date: July 16, 2020Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Moran MAZUZ, Timna NAFTALI
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Publication number: 20200030282Abstract: A method of treating a malignant disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of a first liquid chromatography fraction of a Cannabis extract comprising at least 75% tetrahydrocannabinolic acid (THCA), and a therapeutically effective amount of a second liquid chromatography fraction of a Cannabis extract comprising at least 75% cannabigerolic acid (CBGA), wherein the first liquid chromatography fraction comprises Cannabis derived active ingredients other than the THCA, and the second liquid chromatography fraction comprises Cannabis derived active ingredients other than the CBGA, thereby treating the malignant disease in the subject.Type: ApplicationFiled: March 5, 2018Publication date: January 30, 2020Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization, Mor Research Applications Ltd.Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Dvora NAMDAR, Moran MAZUZ, Ido LAISH, Timna NAFTALI
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Publication number: 20190100731Abstract: A method of preparing an ex-vivo intestinal culture model is provided. The method comprising: (a) providing an intestinal tissue sample; (b) treating the intestinal tissue sample with a protease cleaving an extracellular matrix (ECM) component so as to break cell-cell contacts and obtain an intestinal preparation which maintains the overall intestinal tissue structure including villi and/or intestinal tissue layer orientation; (c) washing the preparation; and (d) culturing the preparation.Type: ApplicationFiled: March 17, 2017Publication date: April 4, 2019Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat, Mor Research Applications Ltd.Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Timna NAFTALI
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Patent number: 10208007Abstract: Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.Type: GrantFiled: September 20, 2012Date of Patent: February 19, 2019Inventors: Yoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi
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Publication number: 20180235213Abstract: A composition comprising at least one polymer, characterized by a surface energy having a value that ranges from 20 mJ/m2 to 60 mJ/m2, and an active agent (e.g., a plant hormone) is disclosed. A delivery device comprising the disclosed composition, adapted for installation on a part of a plant, is further disclosed. A method for applying a plant hormone to a plant is further disclosed.Type: ApplicationFiled: May 11, 2016Publication date: August 23, 2018Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Smadar WEININGER
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Publication number: 20180092954Abstract: Polar extracts of Erodium plants are disclosed as well as pharmaceutical compositions and cosmetic compositions comprising same. Uses of the polar extracts are also disclosed.Type: ApplicationFiled: March 31, 2016Publication date: April 5, 2018Inventors: Hinanit KOLTAI, Yoram KAPULNIK, Marcelo FRIDLENDER, Einav MAYZLISH GATI, Nasser AHMED, Shemer BEN ZION
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Publication number: 20140323563Abstract: Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.Type: ApplicationFiled: September 20, 2012Publication date: October 30, 2014Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat, Georgetown UniversityInventors: Yoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi