Abstract: The present invention is directed to a gear pump having a housing (10?) with an interior pumping chamber (200) and an inlet (40?) to and outlet (42?) from the chamber, the outlet being spaced from the inlet. A pair of rotating gears (330,332) is located in the chamber, the gears including teeth which mesh during gear rotation. The gears are preferably powder metal construction and fixedly secured on a shaft (230,232) having an axis of rotation. A pair of one-piece bearings (210,212) is located in the chamber and journal one of first and second end portions of each shaft (320). The one-piece bearings provide precise alignment of the first and second end portions of the shafts and maintain the shafts in parallel relation.

Abstract: Compounds of the Formula I ##STR1## wherein: the dotted line indicates that a double bond may be present or absent; R.sup.1 is H, methyl or ethyl; R.sup.2 is .alpha.- or .beta.-C.sub.1-10 straight or branched alkyl; R.sup.3 is CO.sub.2 H, CN, CO.sub.2 R.sup.4, COHNR.sup.4, or CON(R.sup.4).sub.2 ; R.sup.4 is H, C.sub.1-10 straight or branched alkyl, aryl, heteroaryl, or aralkyl; Aryl is phenyl, substituted phenyl, naphthyl, or biphenyl; Heteroaryl is pyridyl, pyrrolyl, thienyl, furanyl or quinolinyl; and Aralkyl is C.sub.1-10 alkyl substituted with one to three phenyl or substituted phenyl moieties; and their pharmaceutically acceptable salts are described. These compounds are 5.alpha.-reductase type 1 inhibitors. They may be used for treating conditions associated with an excess of DHT, either alone or in combination with other 5.alpha.-reductase inhibitors.

Abstract: There are disclosed novel ivermectin compounds and a process for preparing them, the novel ivermectin compounds containing straight chain or branched fatty acid residues of from about C.sub.2 to about C.sub.