Abstract: The present disclosure provides copolymers useful in medical devices. For example, the disclosure provides copolymers comprising the polymerization product ester block, ether blocks and diisocyanates. In certain embodiments, the disclosure provides a medical copolymer for implantation comprising ester blocks and ether blocks, wherein: the ester blocks comprise a negative free energy transfer and the ether blocks comprise a positive free energy transfer, the ether and ester blocks are less than 1/10 the length of said copolymer, and, the blocks are distributed such that no domain of contiguous blocks possessing the same polarity of free energy transfer are less than ? of the molecular weight of the copolymer. The disclosure further provides methods of making the aforementioned polymers, and medical devices comprising the polymers.

Abstract: According to the invention, thermoreversible hydrogels are provided, which are prepared from chain-extended poloxamers, having advantageous properties. In addition, the invention provides thermoreversible hydrogels, including biological materials, and a process for the preparation thereof, thermoreversible hydrogels including living cells, application systems for pharmaceutical applications, and an in-vitro-method for forming a composition on a surface.

Abstract: The present invention relates to a formulation for the preparation of a biocompatible, optionally biodegradable open-cell polyurethane foam having open pores also at its surface without a mechanical post-treatment, i.e., having no skin, such a polyurethane foam as well as a method for the preparation thereof and the use thereof. The present invention further relates to a method for the preparation of a scaffold for cell cultures, tissue cultures as well as for tissue engineering which uses the formulation for the manufacture of the open-cell polyurethane foam, as well as a scaffold obtained by this method.

Abstract: The present invention relates to combinations of a building material and a bath fluid for methods for directly printing visual-aid models or elements, in particular, for the use in the office or at home. Furthermore, the present invention relates to the polymers obtained by the reaction of the building material and the bath fluid and to elements or models produced from the combinations according to the present invention. The use of the combinations according to the present invention in rapid prototyping methods enables the production of elements having varying mechanical properties. Coloured elements can be obtained by adding colourants. The elements made from the building materials according to the present invention exhibit mechanical properties, a thermostability and accuracy in every detail, thus rendering them suitable as visual-aid models and discussion models for design, architectural, constructional and other blueprints.