Patents by Inventor Hirdesh Kumar

Hirdesh Kumar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS OF BIFUNCTIONAL INHIBITORS OF TETRACYCLINE INACTIVATING ENZYMES AND METHODS OF USE THEREOF
    Publication number: 20260124217
    Abstract: Among the various aspects of the present disclosure is the provision of bifunctional inhibitors of tetracycline inactivating enzymes and methods of use thereof. Herein, compositions for inhibitors of tetracycline inactivating enzymes are described. Additionally, a method of treatment for multidrug resistant bacterial infections using inhibitors of tetracycline inactivating enzymes is disclosed.
    Type: Application
    Filed: March 6, 2025
    Publication date: May 7, 2026
    Applicant: Washington University
    Inventors: Timothy Wencewicz, Gautam Dantas, Niraj Tolia, Emily Williford, Caitlin DeAngelo, Kevin Blake, Hirdesh Kumar
  • Compositions comprising CelTOS immunogens and antibodies and method of use thereof
    Patent number: 12544441
    Abstract: The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.
    Type: Grant
    Filed: March 23, 2023
    Date of Patent: February 10, 2026
    Assignees: Washington University, University of South Florida
    Inventors: Naraj H. Tolia, John Jimah, Hirdesh Kumar, John Adams, Francis Ntumngia, Samantha Barnes
  • Compositions comprising CelTOS immunogens and antibodies and method of use thereof
    Patent number: 12398184
    Abstract: The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: August 26, 2025
    Assignees: Washington University, University of South Florida
    Inventors: Niraj Tolia, John Jimah, Nichole Salinas, Darya Urusova, John Adams, Shulin Xu, Allison Roth, Hirdesh Kumar
  • ENGINEERED PROTEASE POLYPEPTIDES
    Publication number: 20240409912
    Abstract: The present disclosure provides engineered protease polypeptides, recombinant polynucleotides encoding the engineered protease polypeptides, and uses of the engineered protease polypeptides in therapeutic applications.
    Type: Application
    Filed: May 30, 2024
    Publication date: December 12, 2024
    Inventors: Chinping Chng, Ruth L. Cong, Da Duan, Brian Ferrer, Ravi David Garcia, Nikki D. Kruse, Hirdesh Kumar, Stephen Joshua Macaso Millet, Trica Windgassen, Liang Zhu
  • COMPOSITIONS COMPRISING CelTOS IMMUNOGENS AND ANTIBODIES AND METHOD OF USE THEREOF
    Publication number: 20230338536
    Abstract: The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.
    Type: Application
    Filed: March 23, 2023
    Publication date: October 26, 2023
    Inventors: Naraj H. Tolia, John Jimah, Hirdesh Kumar, John Adams, Francis Ntumngia, Samantha Barnes
  • COMPOSITIONS COMPRISING CelTOS IMMUNOGENS AND ANTIBODIES AND METHOD OF USE THEREOF
    Publication number: 20190276506
    Abstract: The present disclosure provides immunogenic compositions and methods for vaccination with a CelTOS immunogen. The immunogenic composition comprises Babesia, Theileria or Cytauxzoon CelTOS. The immunogenic composition may also comprise CelTOS with structural changes that affect immune recognition.
    Type: Application
    Filed: November 1, 2017
    Publication date: September 12, 2019
    Inventors: Niraj Tolia, John Jimah, Nichole Salinas, Darya Urusova, John Adams, Shulin Xu, Allison Roth, Hirdesh Kumar