Patents by Inventor Hiroaki Inagaki

Hiroaki Inagaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10933065
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Grant
    Filed: March 4, 2019
    Date of Patent: March 2, 2021
    Assignee: ArQule Inc.
    Inventors: Jean-Marc Lapierre, Sudharshan Eathiraj, Nivedita Namdev, Brian Schwartz, Yusuke Ota, Takayuki Momose, Tomoyuki Tsunemi, Hiroaki Inagaki, Kiyoshi Nakayama
  • Patent number: 10851092
    Abstract: The present invention relates to a compound having RET kinase inhibiting action or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases such as cancer. In particular a compound represented by the following general formula (I) as defined herein: (I) or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: December 1, 2020
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Hiroaki Inagaki, Yoshihiro Shibata, Hidenori Namiki, Hideaki Kageji, Kiyoshi Nakayama, Yasuyuki Kaneta
  • Patent number: 10805094
    Abstract: An example operation may include one or more of receiving a blockchain request from a client application in a blockchain network, receiving validity information of a timestamp included in the blockchain request from one or more endorsing nodes in the blockchain network, modifying the timestamp included in the blockchain request based on the validity information received from the one or more endorsing nodes, ordering the blockchain request among a group of blockchain requests based on the modified timestamp with respect to timestamps of other blockchain requests in the group, and storing the ordered group of blockchain requests within a data block among a hash-linked chain of data blocks.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: October 13, 2020
    Assignee: International Business Machines Corporation
    Inventors: Sachiko Yoshihama, Tatsushi Inagaki, Yohei Ueda, Kohichi Kamijoh, Hiroaki Nakamura
  • Publication number: 20200186369
    Abstract: An example operation may include one or more of receiving a blockchain request from a client application, determining a network latency between the client application and the endorsing node based on a network path between the client application and the endorsing node, extracting a timestamp from the blockchain request, determining whether the extracted timestamp is invalid based on the network latency between the client application and the endorsing node, and in response to determining that the timestamp is valid, generating an endorsement for the blockchain request and transmitting the endorsement to the client application.
    Type: Application
    Filed: February 10, 2020
    Publication date: June 11, 2020
    Inventors: Sachiko Yoshihama, Tatsushi Inagaki, Yohei Ueda, Kohichi Kamijoh, Hiroaki Nakamura
  • Patent number: 10656121
    Abstract: Provided are a method and device for detecting arrangement disorder of fibers in a conductive composite material. A coil (7) is disposed at a position at which the coil (7) faces the conductive composite material, and thereby a current can be applied to the conductive composite material. Thus, work or the like for attaching electrodes to the conductive composite material is not required. As a result, the arrangement disorder of the fibers in the conductive composite material can easily be detected. A method for detecting meandering of fibers in a conductive composite material includes a step of disposing a magnetic field sensor (8) at a position at which the magnetic field sensor (8) faces a surface (Sa) of the conductive composite material such that a direction (D) of a magnetosensitive axis is horizontal with the surface (Sa) and is parallel to coil faces (7e).
    Type: Grant
    Filed: July 8, 2016
    Date of Patent: May 19, 2020
    Assignee: IHI Corporation
    Inventors: Akinori Tsuda, Hiroki Kawai, Hiroaki Hatanaka, Yuichi Yamaguchi, Koichi Inagaki
  • Publication number: 20200112444
    Abstract: An example operation may include one or more of receiving a blockchain request from a client application, determining a network latency between the client application and the endorsing node based on a network path between the client application and the endorsing node, extracting a timestamp from the blockchain request, determining whether the extracted timestamp is invalid based on the network latency between the client application and the endorsing node, and in response to determining that the timestamp is valid, generating an endorsement for the blockchain request and transmitting the endorsement to the client application.
    Type: Application
    Filed: October 8, 2018
    Publication date: April 9, 2020
    Inventors: Sachiko Yoshihama, Tatsushi Inagaki, Yohei Ueda, Kohichi Kamijoh, Hiroaki Nakamura
  • Publication number: 20200112446
    Abstract: An example operation may include one or more of receiving a blockchain request comprising a timestamp added by one or more endorsing nodes included within a blockchain network, identifying that the timestamp added by an endorsing node from among the one or more endorsing nodes is a modification to a previously added timestamp provided by the computing node, determining a reputation value for the endorsing node based on a difference between the timestamp added by the endorsing node and the previously added timestamp provided by the computing node, and transmitting the determined reputation value of the endorsing node to an ordering node within the blockchain network.
    Type: Application
    Filed: October 8, 2018
    Publication date: April 9, 2020
    Inventors: Sachiko Yoshihama, Tatsushi Inagaki, Yohei Ueda, Kohichi Kamijoh, Hiroaki Nakamura
  • Publication number: 20200112445
    Abstract: An example operation may include one or more of receiving a blockchain request from a client application in a blockchain network, receiving validity information of a timestamp included in the blockchain request from one or more endorsing nodes in the blockchain network, modifying the timestamp included in the blockchain request based on the validity information received from the one or more endorsing nodes, ordering the blockchain request among a group of blockchain requests based on the modified timestamp with respect to timestamps of other blockchain requests in the group, and storing the ordered group of blockchain requests within a data block among a hash-linked chain of data blocks.
    Type: Application
    Filed: October 8, 2018
    Publication date: April 9, 2020
    Inventors: Sachiko Yoshihama, Tatsushi Inagaki, Yohei Ueda, Kohichi Kamijoh, Hiroaki Nakamura
  • Patent number: 10605777
    Abstract: Provided is a method for inspecting an electroconductive composite material including disposing a detection magnetic field measurement unit, disposing a correction magnetic field measurement unit, applying a current, acquiring a detection magnetic field strength, acquiring a correction magnetic field strength, and detecting a portion in which arrangement of carbon fibers is disordered. The operation includes calculating a correction coefficient using the correction magnetic field strength and correcting the detection magnetic field strength using the correction coefficient.
    Type: Grant
    Filed: August 15, 2016
    Date of Patent: March 31, 2020
    Assignee: IHI Corporation
    Inventors: Hiroki Kawai, Akinori Tsuda, Hiroaki Hatanaka, Yuichi Yamaguchi, Koichi Inagaki
  • Patent number: 10608829
    Abstract: An example operation may include one or more of receiving a blockchain request from a client application, determining a network latency between the client application and the endorsing node based on a network path between the client application and the endorsing node, extracting a timestamp from the blockchain request, determining whether the extracted timestamp is invalid based on the network latency between the client application and the endorsing node, and in response to determining that the timestamp is valid, generating an endorsement for the blockchain request and transmitting the endorsement to the client application.
    Type: Grant
    Filed: October 8, 2018
    Date of Patent: March 31, 2020
    Assignee: International Business Machines Corporation
    Inventors: Sachiko Yoshihama, Tatsushi Inagaki, Yohei Ueda, Kohichi Kamijoh, Hiroaki Nakamura
  • Publication number: 20200061071
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: November 4, 2019
    Publication date: February 27, 2020
    Inventors: Jean-Marc LAPIERRE, Sudharshan EATHIRAJ, Nivedita NAMDEV, Brian SCHWARTZ, Yusuke OTA, Takayuki MOMOSE, Tomoyuki TSUNEMI, Hiroaki INAGAKI, Kiyoshi NAKAYAMA
  • Publication number: 20200039974
    Abstract: The present invention relates to a compound having RET kinase inhibiting action or a pharmaceutically acceptable salt thereof, useful in the treatment of diseases such as cancer. In particular a compound represented by the following general formula (I) as defined herein: (I) or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 28, 2017
    Publication date: February 6, 2020
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Hiroaki Inagaki, Yoshihiro Shibata, Hidenori Namiki, Hideaki Kageji, Kiyoshi Nakayama, Yasuyuki Kaneta
  • Publication number: 20190358233
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: August 5, 2019
    Publication date: November 28, 2019
    Inventors: Craig BATES, Sudharshan Eathiraj, Hiroaki Inagaki, Jean-Marc Lapierre, Takayuki Momose, Kiyoshi Nakayama, Takashi Odagiri, Masahiro Ota, Yusuke Ota, Yoshihiro Shibata, Manish Tandon, Tomoyuki Tsunemi
  • Publication number: 20190192520
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Jean-Marc LAPIERRE, Sudharshan EATHIRAJ, Nivedita NAMDEV, Brian SCHWARTZ, Yusuke OTA, Takayuki MOMOSE, Tomoyuki TSUNEMI, Hiroaki INAGAKI, Kiyoshi NAKAYAMA
  • Patent number: 10245263
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Grant
    Filed: March 3, 2017
    Date of Patent: April 2, 2019
    Assignee: ArQule, Inc.
    Inventors: Jean-Marc Lapierre, Sudharshan Eathiraj, Nivedita Namdev, Brian Schwartz, Yusuke Ota, Takayuki Momose, Tomoyuki Tsunemi, Hiroaki Inagaki, Kiyoshi Nakayama
  • Publication number: 20180055846
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of BTK, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: August 23, 2017
    Publication date: March 1, 2018
    Inventors: Craig BATES, Sudharshan Eathiraj, Hiroaki Inagaki, Jean-Marc Lapierre, Takayuki Momose, Kiyoshi Nakayama, Takashi Odagiri, Masahiro Ota, Yusuke Ota, Yoshihiro Shibata, Manish Tandon, Tomoyuki Tsunemi
  • Publication number: 20170182053
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Application
    Filed: March 3, 2017
    Publication date: June 29, 2017
    Inventors: Jean-Marc LAPIERRE, Sudharshan EATHIRAJ, Nivedita NAMDEV, Brian SCHWARTZ, Yusuke OTA, Takayuki MOMOSE, Tomoyuki TSUNEMI, Hiroaki INAGAKI, Kiyoshi NAKAYAMA
  • Patent number: 9630968
    Abstract: The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prodrug, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composition comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
    Type: Grant
    Filed: December 23, 2015
    Date of Patent: April 25, 2017
    Assignee: ArQule, Inc.
    Inventors: Jean-Marc Lapierre, Sudharshan Eathiraj, Nivedita Namdev, Brian Schwartz, Yusuke Ota, Takayuki Momose, Tomoyuki Tsunemi, Hiroaki Inagaki, Kiyoshi Nakayama
  • Patent number: 8952010
    Abstract: A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom Ar1 represents a bicyclic heterocyclic group represented by the following formula: ?and Ar2 represents a bicyclic heterocyclic group represented by the following formulae:
    Type: Grant
    Filed: February 6, 2012
    Date of Patent: February 10, 2015
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Hiroaki Inagaki, Tetsunori Fujisawa, Masao Itoh, Aki Yokomizo, Toshifumi Tsuda, Saito Higuchi, Biswajit Das, Rita Katoch, Dilip J. Upadhyay
  • Publication number: 20140187542
    Abstract: A compound represented by the following formula (I) or a salt thereof: wherein R represents a hydrogen atom, a hydroxy group, or a halogen atom Ar1 represents a bicyclic heterocyclic group represented by the following formula: and Ar2 represents a bicyclic heterocyclic group represented by the following formulae:
    Type: Application
    Filed: February 6, 2012
    Publication date: July 3, 2014
    Applicant: DAIICHI SANKYO COMPANY, LIMITED
    Inventors: Hiroaki Inagaki, Tetsunori Fujisawa, Masao Itoh, Aki Yokomizo, Toshifumi Tsuda, Saito Higuchi, Biswajit Das, Rita Katoch, Dilip J. Upadhyay