Abstract: A method of screening for a substance that acts on a cell mass includes producing a cell mass by three-dimensional culture of primary cancer cells using a tumor tissue, adding a test substance to the cell mass, and evaluating an action of the test substance on the cell mass. The cell mass is produced by culturing cells obtained from the tumor tissue in a medium containing a 5% v/v or less extracellular matrix on a substantially low-adhesive cell culture substrate and producing the cell mass of the primary cancer cells.

Abstract: A pump is provided that includes a tube 1, tube rotors 21A, 21B, and 21C in contact with the tube 1, a case 3 containing the tube 1 and tube rotors 21A, 21B, and 21C, and a drive apparatus 10 that rotates the tube rotors 21A, 21B, and 21C from outside the case 3 without contacting the tube rotors 21A, 21B, and 21C.

Abstract: A method of producing a cell mass by three-dimensional culture of primary cancer cells having proliferative ability and properties of handleability, versatility, and high-throughput performance, in which a tumor tissue is used as a starting material, proliferation of cells such as fibroblasts other than cancer cells is inhibited, and the cell mass includes primary cancer cells as a main component. The object is achieved by providing a method of producing a cell mass by three-dimensional culture of primary cancer cells using a tumor tissue, including: a three-dimensional culture step of culturing cells obtained from the tumor tissue in a medium containing a 5% v/v or less extracellular matrix on a substantially low-adhesive cell culture substrate.

Abstract: The information processing circuit 10 performs operations on layers in deep learning, and includes a product sum circuit 11 which performs a product-sum operation using input data and parameter values, and a parameter value output circuit 12 which outputs the parameter values, wherein the parameter value output circuit 12 is composed of a combinational circuit.

Abstract: An object of the invention is to provide an optical detection method and a quantification method of a product obtained by amplifying a target nucleic acid contained in a paper piece of a blood spot in a filter paper obtained by blotting blood on a filter paper and then drying the blood using nucleic acid amplification reaction by real-time PCR and to further provide a kit used for the methods. The invention provides a method and a kit which can optically detect and quantify a target nucleic acid from a dried blood spot in a filter paper by real-time PCR without any complicated pretreatment, by adjusting the size of the punched piece of the dried blood spot in a filter paper or the whole blood amount contained in the punched piece, the amount of the PCR reaction reagent, or performing the PCR reaction in a PCR reaction tube closed with a cap.

Abstract: Each chip 70 includes weight storage unit for storing weights for each edge determined by learning under the condition that channels in a first layer that is a layer in a neural network and channels in a 0th layer that is a previous layer to the first layer are divided into groups whose number is equal to the number of the chips, respectively, the groups of the channels in the first layer and the groups of the channels in the 0th layer and the chips are associated, an edge is set between the channels belonging to corresponding groups, an edge is set between the channels belonging to non-corresponding groups under a restriction. The weight storage unit stores the weights determined for the edge between the channels, each of which corresponds to each chip including the weight storage unit, belonging to corresponding groups.

Abstract: The determining unit 72 divides channels in the 0th layer and channels in the first layer into groups whose number is equal to the number of chips that are included in an operation device executing an operation of the neural network using a learning result of the weight for each edge, respectively. The determining unit 72 determines association of the groups of the channels in the 0th layer and the groups of the channels in the first layer and the chips included in the operation device, and edges to be removed, and removes the edges to be removed. The weight assignment unit 73 stores the weights of the edges in the weight storage unit in the chip corresponding to the edge.

Abstract: Provided is a solid-state battery in which single cell bodies as a solid-state thin film battery are more suitably stacked. In the solid-state battery technology, an adhesive layer is provided between a plurality of stacked single cell bodies and the adhesive layer is configured to cover each cell element portion.

Abstract: An object detecting device is configured of a laser beam generating unit that generates a laser beam, a light receiving unit that outputs a received light signal based on a laser beam reflected from a detection target object, a distance calculating unit that calculates a distance to the detection target object based on a time required from an emission of the laser beam until a reception of the received light signal, and a wave height value calculating unit that obtains an approximate straight line based on inclinations of a rise and a fall of a waveform of the received light signal at a set threshold, and calculates a wave height value of the received light signal based on the approximate straight line, wherein information regarding the detection target object is collected based on the wave height value, in addition to the distance being calculated.

Abstract: An electro-optic waveguide device may include a slot waveguide including a lower high-refractive-index layer with a first refractive index and an upper high-refractive-index layer with a second refractive index, wherein the lower high-refractive-index layer and the upper high-refractive-index layer have conductivity and are disposed to face each other with a gap; and a slot part formed as a low-refractive-index layer, wherein the low-refractive-index layer is formed of a material producing an electro-optic effect and has a third refractive index lower than the first refractive index and the second refractive index, wherein the low-refractive-index layer is formed in the gap to come into contact with the lower high-refractive-index layer and the upper high-refractive-index layer, and wherein one of the lower high-refractive-index layer or the upper high-refractive-index layer includes a stretch stretching on both sides of a contact portion with the slot part in a width direction intersecting a transmission dir

Abstract: A method of producing a cell mass by three-dimensional culture of primary cancer cells having proliferative ability and properties of handleability, versatility, and high-throughput performance, in which a tumor tissue is used as a starting material, proliferation of cells such as fibroblasts other than cancer cells is inhibited, and the cell mass includes primary cancer cells as a main component. The object is achieved by providing a method of producing a cell mass by three-dimensional culture of primary cancer cells using a tumor tissue, including: a three-dimensional culture step of culturing cells obtained from the tumor tissue in a medium containing a 5% v/v or less extracellular matrix on a substantially low-adhesive cell culture substrate.

Abstract: An electro-optic waveguide device may include a slot waveguide including a lower high-refractive-index layer with a first refractive index and an upper high-refractive-index layer with a second refractive index, wherein the lower high-refractive-index layer and the upper high-refractive-index layer have conductivity and are disposed to face each other with a gap; and a slot part formed as a low-refractive-index layer, wherein the low-refractive-index layer is formed of a material producing an electro-optic effect and has a third refractive index lower than the first refractive index and the second refractive index, wherein the low-refractive-index layer is formed in the gap to come into contact with the lower high-refractive-index layer and the upper high-refractive-index layer, and wherein one of the lower high-refractive-index layer or the upper high-refractive-index layer includes a stretch stretching on both sides of a contact portion with the slot part in a width direction intersecting a transmission dir

Abstract: In an optical transmitter module for combining three or more optical signals different in intensity with an optical multiplexer to generate a PAM signal, the influence of the beat noise and the chromatic dispersion due to the difference in wavelength is reduced. The optical transmitter module includes first through third optical signal sources adapted to output respective optical signals binary intensity modulated with different amplitude from each other, and a combining section. The combining section has a wavelength multiplexer adapted to wavelength-multiplex a plurality of input optical signals having different wavelengths from each other while keeping the respective polarization states, and a polarization multiplexer adapted to polarization-multiplex a pair of input optical signals having respective polarization states perpendicular to each other, and the combining section combines the input optical signals from the first through third optical signal sources with each other to generate a PAM8 signal.

Abstract: To provide a water repellent composition whereby a moisture permeable waterproof film is rendered less likely to be peeled from an article treated by the water-repellent composition. The water repellent composition comprises a copolymer (A) having structural units based on a monomer (a) and structural units based on a monomer (b), a polymer (B) having an amino group, an ammonium salt group or an amide group as a pendant group, and an aqueous medium. The monomer (a) is a compound represented by RF-Q-Z—C(O)C(R)?CH2 (wherein RF is a C4-6 perfluoroalkyl group, Q is either a divalent hydrocarbon group containing no fluorine atom or a single bond, Z is —O— or NH—, and R is a hydrogen atom, a methyl group or a chlorine atom). The monomer (b) is a (meth)acrylate having no polyfluoroalkyl group and having a C12-22 alkyl group.

Abstract: An optical module includes a semiconductor optical device in which an active layer located at one side, an electrode located at the same side, and a mirror that reflects light toward the side opposite the electrode are monolithically integrated, a sub-mount having one surface on which a first wiring pattern is formed, a substrate in which an optical waveguide and a grating coupler are formed in a surface layer of the substrate, a spacer having an upper surface on which a second wiring pattern is formed, and a wire. The sub-mount is mounted on the spacer. The first wiring pattern on the sub-mount faces part of the second wiring pattern on the spacer and is electrically connected thereto. The second wiring pattern on the spacer includes a pad being disposed in a region exposed from the sub-mount and being bonded to the wire.

Abstract: A liquid food composition that can be conveniently ingested or given with a tube and contains reduced aggregates in the composition is provided. A liquid food composition that shows fluidity in the neutral region, but solidifies in the stomach environment is further provided. According to the production method of the present invention, generation of fine particles in the production process of a liquid food composition containing a divalent metal salt, a protein, and water-soluble dietary fibers is reduced. Therefore, emulsification stability of the composition is improved, clogging of aggregates in strainer disposed in the production line etc. are eliminated, and thus the composition can be efficiently produced.

Abstract: In an optical transmitter module for combining three or more optical signals different in intensity with an optical multiplexer to generate a PAM signal, the influence of the beat noise and the chromatic dispersion due to the difference in wavelength is reduced. The optical transmitter module includes first through third optical signal sources adapted to output respective optical signals binary intensity modulated with different amplitude from each other, and a combining section. The combining section has a wavelength multiplexer adapted to wavelength-multiplex a plurality of input optical signals having different wavelengths from each other while keeping the respective polarization states, and a polarization multiplexer adapted to polarization-multiplex a pair of input optical signals having respective polarization states perpendicular to each other, and the combining section combines the input optical signals from the first through third optical signal sources with each other to generate a PAM8 signal.

Abstract: An optical module includes a semiconductor optical device in which an active layer located at one side, an electrode located at the same side, and a mirror that reflects light toward the side opposite the electrode are monolithically integrated, a sub-mount having one surface on which a first wiring pattern is formed, a substrate in which an optical waveguide and a grating coupler are formed in a surface layer of the substrate, a spacer having an upper surface on which a second wiring pattern is formed, and a wire. The sub-mount is mounted on the spacer. The first wiring pattern on the sub-mount faces part of the second wiring pattern on the spacer and is electrically connected thereto. The second wiring pattern on the spacer includes a pad being disposed in a region exposed from the sub-mount and being bonded to the wire.

Abstract: On seed metal layer of first metal, pedestal and counter electrode are formed of second metal by plating, adjacent to free space region. The free space region is filled with first sacrificial layer. By using resist pattern, second sacrificial metal layer is formed, extending from the first sacrificial layer to a portion of the pedestal, and lower structure of third metal is formed on the second sacrificial layer, by contiguous plating, exposing a portion of the pedestal not formed with the second sacrificial layer, the third metal having composition and thermal expansion coefficient equivalent to the second metal. Upper structure of fourth metal having composition and thermal expansion coefficient equivalent to the second and third metals is formed on the pedestal and the lower structure by plating. The first and second sacrificial layers are removed, leaving an electric equipment with a movable portion.

Abstract: An optical module includes a semiconductor optical device in which an active layer located at one side, an electrode located at the same side, and a mirror that reflects light toward the side opposite the electrode are monolithically integrated, a sub-mount having one surface on which a first wiring pattern is formed, a substrate in which an optical waveguide and a grating coupler are formed in a surface layer of the substrate, a spacer having an upper surface on which a second wiring pattern is formed, and a wire. The sub-mount is mounted on the spacer. The first wiring pattern on the sub-mount faces part of the second wiring pattern on the spacer and is electrically connected thereto. The second wiring pattern on the spacer includes a pad being disposed in a region exposed from the sub-mount and being bonded to the wire.