Patents by Inventor Hiroaki Kohno

Hiroaki Kohno has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor
    Patent number: 7479371
    Abstract: The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).
    Type: Grant
    Filed: April 9, 2003
    Date of Patent: January 20, 2009
    Assignees: Tokai University, Kyowa Hakko Kogyo Co., Ltd., Kyowa Medex Co., Ltd.
    Inventors: Kiyoshi Ando, Tomomitsu Hotta, Chie Ito, Hidenao Sato, Akiko Furuya, Kenya Shitara, Seiji Sugimoto, Hiroaki Kohno
  • Antidepressants or foods and beverage for antidepression
    Publication number: 20070021355
    Abstract: An object of the present invention is to provide antidepressants or foods and drinks for antidepression. To solve the present problem, the present invention provides antidepressants or foods and drinks for antidepression comprising, as an active ingredient, a compound represented by formula (I): (wherein R1, R2, R3 and R4, which may be the same or different, each represent a hydrogen atom, substituted or unsubstituted lower alkyl, or the like; R5 represents a hydrogen atom, hydroxy, or the like; R6 represents a hydrogen atom, or the like; R7 represents a hydrogen atom or substituted or unsubstituted lower alkyl; and R8, R9, R10 and R11, which may be the same or different, each represent a hydrogen atom or substituted or unsubstituted lower alkyl) or a salt thereof.
    Type: Application
    Filed: May 28, 2004
    Publication date: January 25, 2007
    Inventors: Hiroaki Kohno, Hideaki Kusaka
  • Method of judging leukemia, pre-leukemia or aleukemic malignant blood disease and diagnostic therefor
    Publication number: 20060084122
    Abstract: The present invention relates to a method for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases, a method of discriminating leukemia from pre-leukemia or aleukemic malignant blood diseases, a method of discriminating aplastic anemia from myelodysplastic syndrome, a method of diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells, and a method of diagnosing the graft versus host disease, each of said methods comprising quantifying stem cell growth factor (SCGF). The present invention also makes it possible to provide an agent for diagnosing leukemia, pre-leukemia or aleukemic malignant blood diseases and an agent for diagnosing delayed engraftment of the hematopoietic stem cells after transplantation of the hematopoietic stem cells or an agent for diagnosing graft versus host disease (GVHD), each containing as an active ingredient an antibody reacting with stem cell growth factor (SCGF).
    Type: Application
    Filed: April 9, 2003
    Publication date: April 20, 2006
    Inventors: Kiyoshi Ando, Tomomitsu Hotta, Chie Ito, Hidenao Sato, Akiko Furuya, Kenya Shatara, Seiji Sugimoto, Hiroaki Kohno
  • Method of quantifying denatured lipoprotein, reagents for quantifying denatured lipoprotein, method of detecting circulatory disease and reagents for detecting circulatory disease
    Publication number: 20040241744
    Abstract: The present invention provides a method for quantitatively determining a denatured lipoprotein in a biological sample which comprises contacting the biological sample with an antibody against phosphocholine and determining a formed immune complex, a method for detecting a cardiovascular disease which comprises contacting the biological sample with an antibody against phosphocholine and determining a formed immune complex, a reagent for quantitatively determining a denatured lipoprotein which comprises an antibody against phosphocholine, and a reagent for detecting a cardiovascular disease which comprises an antibody against phosphocholine.
    Type: Application
    Filed: January 8, 2004
    Publication date: December 2, 2004
    Inventors: Hiroaki Kohno, Takashi Yanagisawa, Toshiyuki Masunari
  • Compound 2-amino-3-[2-(&agr;-mannopyranosyl)indol-3-yl]propionic acid, process for preparing the same, and method for inspecting function of living body with the novel compound
    Patent number: 6610502
    Abstract: The present invention relates to a novel endogenous compound 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid; to a method for testing a biological function by quantitating 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid in a collected biological sample and determining the biological function based on the quantitated values; to an antibody specifically reactive with 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid; to a hybridoma that produces the antibody; to a method for immunologically quantitating 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid in a sample by using the antibody; and to a process for producing a 2-amino-3-[2-(&agr;-mannopyranosyl)indole-3-yl]propionic acid derivative.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: August 26, 2003
    Assignees: Kyowa Medex Co., Ltd., Marine Biotechnology Institute Co., Ltd.
    Inventors: Hiroaki Kohno, Osamu Yonekawa, Yutaka Fujise, Kentaro Horiuchi, Kyoko Adachi, Hiroshi Sano