Patents by Inventor Hiroaki Matsunami

Hiroaki Matsunami has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR IDENTIFYING LIGANDS OF ODORANT RECEPTORS
    Publication number: 20100248390
    Abstract: The present invention relates to compositions and methods for identifying odorant-odorant receptor interactions. In particular, the present invention relates to in silico methods for identifying odorant receptor-odorant interactions based on chemical and physical properties of odorant receptors and odorants.
    Type: Application
    Filed: March 2, 2010
    Publication date: September 30, 2010
    Applicant: DUKE UNIVERSITY
    Inventors: Hiroaki Matsunami, Joel D. Mainland
  • MODULATORS OF ODORANT RECEPTORS
    Publication number: 20100222561
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Application
    Filed: April 26, 2010
    Publication date: September 2, 2010
    Applicant: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang
  • COMPOSITIONS AND METHODS FOR CHARACTERIZING AND REGULATING OLFACTORY SENSATION
    Publication number: 20100143337
    Abstract: The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations associated with altered olfactory sensation states, as well as methods of screening for therapeutic agents, ligands, and modulators of OR7D4 receptors.
    Type: Application
    Filed: May 8, 2008
    Publication date: June 10, 2010
    Applicants: Duke University, The Rockefeller University
    Inventors: Hiroaki Matsunami, Andreas Keller, Hanyi Zhuang, Qiuyi Chi, Leslie B. Vosshall
  • SOUR TASTE RECEPTOR COMPOSITIONS AND METHODS
    Publication number: 20100136602
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Application
    Filed: December 7, 2009
    Publication date: June 3, 2010
    Applicant: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • Modulators of odorant receptors
    Patent number: 7691592
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: April 6, 2010
    Assignee: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang
  • Sour taste receptor compositions and methods
    Patent number: 7629134
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Grant
    Filed: July 10, 2007
    Date of Patent: December 8, 2009
    Assignee: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • Modulators of odorant receptors
    Patent number: 7625714
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: December 1, 2009
    Assignee: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang
  • MODULATORS OF ODORANT RECEPTORS
    Publication number: 20090124003
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Application
    Filed: October 30, 2008
    Publication date: May 14, 2009
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang
  • MODULATORS OF ODORANT RECEPTORS
    Publication number: 20090123997
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Application
    Filed: October 30, 2008
    Publication date: May 14, 2009
    Inventors: HIROAKI MATSUNAMI, MOMOKA MATSUNAMI, HARUMI SAITO, HANYI ZHUANG
  • MODULATORS THAT PROMOTE CELL SURFACE EXPRESSION OF ODORANT RECEPTORS
    Publication number: 20090092997
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Application
    Filed: September 9, 2008
    Publication date: April 9, 2009
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang
  • Modulators that promote cell surface expression of odorant receptors
    Patent number: 7425445
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: September 16, 2008
    Assignee: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang
  • Modulators of odorant receptors
    Publication number: 20080124742
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Application
    Filed: June 8, 2007
    Publication date: May 29, 2008
    Applicant: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang
  • Sour taste receptor compositions and methods
    Publication number: 20080081345
    Abstract: The present invention relates to sour taste receptors and compositions and methods thereof. In particular, the present invention provides assays and methods of screening for ligands specific for sour taste receptors. Additionally, the present invention provides methods for screening for accessory proteins and mutations, polymorphisms and other potential sour taste receptor protein mutations that are associated with disease states, and therapeutic agents, ligands, and modulators of such proteins. The present invention also provides compositions and methods for modulating sour taste receptors in vitro and in vivo.
    Type: Application
    Filed: July 10, 2007
    Publication date: April 3, 2008
    Applicant: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Yoshiro Ishimaru
  • Modulators of odorant receptors
    Publication number: 20060057640
    Abstract: The present invention relates to polypeptides capable of promoting odorant receptor cell surface localization and odorant receptor functional expression. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for odorant receptor accessory protein polymorphisms and mutations associated with disease states, as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.
    Type: Application
    Filed: June 20, 2005
    Publication date: March 16, 2006
    Applicant: Duke University
    Inventors: Hiroaki Matsunami, Momoka Matsunami, Harumi Saito, Hanyi Zhuang