Abstract: An object of the present disclosure is at least to provide a technique for promoting elimination of a methyl group(s) of a methoxy group(s) in causing a microorganism having a demethylation ability of eliminating a methyl group(s) of a methoxy group(s) from a compound with the methoxy group(s) in a side chain(s) to produce a demethylated compound in which a methyl group(s) of a methoxy group(s) has eliminated from a compound with the methoxy group(s) in a side chain(s).

Abstract: The present invention aims at establishing a novel therapy for facioscapulohumeral muscular dystrophy. An oligonucleotide or a pharmaceutically acceptable salt thereof, wherein the oligonucleotide comprises an oligonucleotide of 15-30 bases consisting of a nucleotide sequence complementary to the region of nucleotide Nos. 502-556 or 578-612 of DUX4-fl mRNA consisting of the nucleotide sequence as shown in SEQ ID NO: 1; the 5? and/or 3? end of the oligonucleotide may be chemically modified; and the oligonucleotide is capable of switching the splice form of the DUX4 gene from DUX4-fl to DUX4-s. A pharmaceutical drug comprising the above oligonucleotide or a pharmaceutically acceptable salt thereof (e.g. therapeutic for facioscapulohumeral muscular dystrophy).

Abstract: An object of the present invention is to provide a non-contact electricity feeding facility that feeds electricity to a rail guided vehicle in a non-contact manner, the facility enabling a temperature abnormality in a feeding cable to be reliably detected using a simple configuration. The present invention provides a non contact electricity feeding facility 7 that feeds electricity to a rail guided vehicle 5 in a non-contact manner, the facility including a thermostat 43 mounted at an end of the feeding cable 9 at a connection between a feeding cable 9 and a bus bar 12 for junction or termination which is required for feeding electricity, the thermostat 43 operating at least a predetermined temperature, and a temperature abnormality detecting circuit 44 that detects that the thermostat 43 has operated.

Abstract: A medicinal composition containing one or more compounds selected from the compounds represented by the following formula (I), salts of these compounds, solvates of these compounds and solvates of these salts and being capable of reducing the contact of the compounds with the components in the bile or pancreatic juice.

Abstract: Provided are vitamin D.sub.3 derivatives expressed by the following general formula [1] ##STR1## [wherein, R.sub.1 and R.sub.2 are each a hydrogen atom, a trialkylsilyl group, an acetyl group, a methoxymethyl group, or a tetrahydropyranyl group; R.sub.3 and R.sub.4 are each a hydrogen atom, a hydroxyl group, an acyloxy group, an alkyloxy group, an alkylthio group or an alkyl group which is optionally substituted; R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are each a hydrogen atom, a hydroxyl group, an alkyl group or an acyloxy group; R.sub.9 is a hydrogen atom, a hydroxyl group, an alkyl group or an alkylthio group; R.sub.10 is a hydrogen atom, an alkyl group or an alkyloxy group; A and B are each a hydrogen atom, a hydroxyl group, or together express a single bond; X and Y express a carbonyl oxygen, or one of them is a hydrogen atom and the other is a hydroxyl group or an acyloxy group; n is an integer of 0 to 2; m is an integer of 0 to 2], and a method for manufacturing the derivatives.

Abstract: The present invention relates to a microbiocidal mat to be installed at the entrance of a clean zone in a biochemical plant, a hospital or a like facility, the mat comprising a mat body 1 containing an alkaline compound 5 as a microbicide. The mat body may further contain a surface active agent and/or a water-retentive agent, the water-retentive agent comprising a substance which is stable against water and has deliquescence. Where the mat body 1 contains the compound and the agents in powdery crystallized states, the mat body 1 is used in a wet state by supplying water thereto after the mat is installed at the entrance. When the mat body 1 is supplied with water, the alkaline compound is dissolved in water within the mat body 1 so that the mat body 1 is imparted with microbiocidal activity.