Abstract: Compounds of the formula ##STR1## wherein R.sup.1 is a C.sub.10-24 alkyl group, R.sup.2 is a C.sub.1-4 alkyl group or a phenyl-C.sub.1-3 alkyl group and A.sup.+ is a heterocyclic group containing a quaternized nitrogen, and physiologically acceptable salts thereof have platelet activating factor inhibiting activity and are useful in the prevention and treatment of various circulatory diseases or allergic diseases.

Abstract: 7-Deazapurine derivatives of the formula (I): ##STR1## (R.sup.1 is an acyl group; each of R.sup.2 and R.sup.3 is an alkyl, alkenyl or aralkyl group of alternatively R.sup.2 and R.sup.3, taken together with the adjacent nitrogen atom, form a cyclic amino group, and each of said alkyl group, alkenyl group, aralkyl group and cyclic amino group has a methylene group in .alpha.-position) and salts thereof are of value as intermediates for the production of antitumor agents, biological reagents, etc.

Abstract: New carbamic acid esters, inclusive of salts thereof, which have the formula: ##STR1## wherein n is zero or 1; R.sup.1 and R.sup.2 independently represent --H, --OCH.sub.3 or --OCONHR.sup.6 in which R.sup.6 is C.sub.8-26 aliphatic hydrocarbon residue provided that at least one of R.sup.1 and R.sup.2 is --OCONHR.sup.6 ; and R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen or lower alkyl, or ##STR2## represents cyclic ammonio, exhibit inhibitory activity to multiplication of tumor cells and antimicrobial activity.

Abstract: Novel phospholipids, inclusive of pharmaceutically acceptable salts thereof, of the formula ##STR1## wherein R.sup.1 is an aliphatic hydrocarbon residue of 15 to 20 carbon atoms, R.sup.2 is an alkyl group of 1 to 4 carbon atoms and R.sup.3 is a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, exhibit inhibitory activity to multiplication of tumor cells and are useful for inhibiting multiplication of tumor cells and prolonging the survival time of tumor-bearing warm-blooded animal.

Abstract: New ethylene glycol derivatives, inclusive of salts thereof, which have the formula: ##STR1## wherein n is an integer of 1 to 15; R.sup.1 is an aliphatic hydrocarbon group containing 6 to 26 carbon atoms; R.sup.2, R.sup.3 and R.sup.4 are independently H or lower alkyl, or ##STR2## represents a cyclic ammonio group, exhibit inhibitory activity to multiplication of tumor cells and antimicrobial activity.

Abstract: Ethylene glycol derivatives, inclusive of salts thereof, which have the formula: ##STR1## wherein R.sup.1 is C.sub.8-26 aliphatic hydrocarbon residue; R.sup.2, R.sup.3 and R.sup.4 are each hydrogen or lower alkyl which may be substituted, or --N.sup.+ R.sup.2 R.sup.3 R.sup.4 represents cyclic ammonio, exhibit inhibitory activity to multiplication of tumor cells and antimicrobial activity.

Abstract: Novel deazapurine derivatives of the formula: ##STR1## wherein R.sup.1 is C.sub.1-18 alkyl which may be substituted with di-C.sub.1-3 alkyl amino; C.sub.1-18 alkenyl; C.sub.3-8 cyloalkyl; C.sub.5-8 cycloalkenyl; C.sub.7-13 aralkyl which may be substituted with C.sub.1-4 alkoxy, C.sub.1-4 alkanoyl, C.sub.2-4 alkoxycarbonyl, hydroxy, amino, nitro, trifluoromethyl or C.sub.1-4 alkanoylamido; or C.sub.6-10 aryl andR.sup.2 is hydrogen or C.sub.7-13 aralkyl or,R.sup.1 and R.sup.2, taken together with the adjacent nitrogen atom, form a piperidine ring, and salt thereof are selectively taken up by tumor cells and have antitumor activity.

Abstract: New carbamic acid esters, inclusive of salts thereof, which have the formula: ##STR1## wherein n is zero or 1; R.sup.1 and R.sup.2 independently represent --H, --OCH.sub.3 or --OCONHR.sup.6 ; in which R.sup.6 is C.sub.8-26 aliphatic hydrocarbon residue provided that at least one of R.sup.1 and R.sup.2 is --OCONHR.sup.6 ; and R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen or lower alkyl, or ##STR2## represents cyclic ammonio, exhibit inhibitory activity to multiplication of tumor cells and antimicrobial activity.

Abstract: An electronic timepiece has an alarm function using circuitry and an electroacoustic transducer to generate a selected melody. The frequencies of the generated tones lie close to those of the standard chromatic or diatonic scales, and are produced by dividing the frequency of a time-standard signal. A plurality of notes can be generated.

Abstract: A new and industrially useful method of producing 1(or 1,3-bis)-(tetrahydro-2-furyl)-5-fluorouracil or a mixture thereof by reacting 5-fluorouracil with 2,3-dihydrofuran at elevated temperature in a closed vessel. Depending upon reaction conditions, each of the above 5-fluorouracil derivatives or a mixture of them is produced.1,3-Bis-(tetrahydro-2-furyl)-5-fluorouracil thus formed can be converted to 1-(tetrahydro-2-furyl)-5-fluorouracil by solvolysis under non-acidic conditions.

Abstract: A method of combating bacterial infections in humans involves the administration of an antibacterially effective amount of a compound of the formula: ##STR1## wherein R is phenyl or thienyl group, and R' is a group which constitutes together with the adjacent nitrogen atom a pyridinium group that is unsubstituted or substituted by carbamoyl, or a 4'-methyl-5'-(.beta.-hydroxyethyl)-thiazolium or a pharmaceutically acceptable salt thereof, to a patient. This method is effective particularly against Pseudomonas aeruginosa as well as against other Gram negative and positive microorganisms.

Abstract: Novel cephalosporins shown by the general formula: ##STR1## wherein Y is an acyloxy group, a quaternary ammonium group or a group of the formula: --S--R in which R is a nitrogen-containing heterocyclic group, and pharmaceutically acceptable salts thereof have high antibacterial properties against Gram-positive and Gram-negative bacteria including Pseudomonas aeruginosa and Serratia marcescens.

Abstract: N.sup.1 -(2-tetrahydrofuryl)-5-fluorouracil is produced in high yield by reacting 5-fluorouracil with 2,3-dihydrofuran in the presence of trimethylsilyl chloride and a tertiary amine and treating the resultant mixture with an aqueous alkaline solution.

Abstract: Novel cephalosporins of the formula, ##STR1## wherein R is a hydrogen atom or an alkyl, aryl or thienyl group, and R' is a group which constitutes together with the adjacent nitrogen atom a 5- or 6-membered ring containing 1 or 2 nitrogen atoms, which are effective particularly against Pseudomonas aeruginosa as well as against other Gram negative and positive microorganisms, for example, N-[7-(.alpha.-sulfophenylacetamido)ceph-3-em-3-ylmethyl] pyridinium 4-carboxylate, N-[7-(.alpha.-sulfo-3'-thienylacetamido)ceph-3-em-3-ylmethyl] pyridinium-4-carboxylate, and their pharmaceutically acceptable salts thereof. Sodium salt of the former is prepared by, e.g. reacting sodium 7-(.alpha.-sulfophenylacetamido) cephalosporanate with pyridine in water.

Abstract: Novel cephalosporanic acid derivatives which are active against both Gram positive and Gram negative pathogenic bacteria, particularly Pseudomonas, and which have .alpha.-sulfoacylamino group at 7-position. A few examples of the compounds are 7-(.alpha.-sulfophenylacetamido)-cephalosporanic acid, 7-(.alpha.-sulfopropionamido)-cephalosporanic acid, 7-(.alpha.-sulfocapronamido)-cephalosporanic acid. They are prepared by condensing 7-aminocephalosporanic acid or salts thereof with .alpha.-sulfocarboxylic acid or functional derivatives thereof in the presence of a solvent at -2.degree. - 10.degree. C.

Abstract: Novel cephalosporanic acid derivatives which are active against both Gram positive and Gram negative pathogenic bacteria, particularly Pseudomonas, and which have an .alpha.-sulfoacylamino group at 7-position. A few examples of the compounds are 7-(.alpha.-sulfophenylacetamido)-cephalosporanic acid, 7-(.alpha.-sulfopropionamido)-cephalosporanic acid, 7-(.alpha.-sulfocapronamido)-cephalosporanic acid. They are prepared by condensing 7-aminocephalosporanic acid or salts thereof with .alpha.-sulfocarboxylic acid or functional derivatives thereof in the presence of a solvent at -2.degree. - 10.degree. C.