Patents by Inventor Hiroaki Onoe
Hiroaki Onoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220259541Abstract: A cell fiber production system comprises: a first flow path through which a first fluid containing a cell flows; a second flow path for allowing a second fluid for preparing a hydrogel to converge around the first fluid in the first flow path; and an ejection port through which at least the first fluid and the second fluid are discharged together. The cell fiber production system is constructed that, at a start stage of production of a cell fiber, the first fluid is delivered after the second fluid reaches at least a convergence point between the first flow path and the second flow path.Type: ApplicationFiled: November 4, 2019Publication date: August 18, 2022Applicant: CELLFIBER CO., LTD.Inventors: Hiroaki ONOE, Kazuhiro IKEDA, Kayoko SHOJI
-
Patent number: 10221382Abstract: The present invention relates to a hollow microfiber comprising (1) one or more cell-adhesive layers having a cell-adhesive hydrogel, (2) an outer shell layer having a high-strength hydrogel that covers the outer periphery of the cell-adhesive layer that is positioned farthest from the center axis among the one or more cell-adhesive layers, and (3) a cell layer that covers the inner periphery of the cell-adhesive layer that is positioned closest to the center axis among the one or more cell-adhesive layers. The present invention also relates to a method of manufacturing the hollow microfiber and a kit for carrying out the manufacturing method.Type: GrantFiled: May 20, 2015Date of Patent: March 5, 2019Assignee: THE UNIVERSITY OF TOKYOInventors: Shoji Takeuchi, Hiroaki Onoe, Shigenori Miura
-
Patent number: 9969970Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.Type: GrantFiled: March 1, 2016Date of Patent: May 15, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
-
Publication number: 20170130184Abstract: The present invention relates to a hollow microfiber comprising (1) one or more cell-adhesive layers having a cell-adhesive hydrogel, (2) an outer shell layer having a high-strength hydrogel that covers the outer periphery of the cell-adhesive layer that is positioned farthest from the center axis among the one or more cell-adhesive layers, and (3) a cell layer that covers the inner periphery of the cell-adhesive layer that is positioned closest to the center axis among the one or more cell-adhesive layers. The present invention also relates to a method of manufacturing the hollow microfiber and a kit for carrying out the manufacturing method.Type: ApplicationFiled: May 20, 2015Publication date: May 11, 2017Inventors: Shoji TAKEUCHI, Hiroaki ONOE, Shigenori MIURA
-
Publication number: 20160319238Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.Type: ApplicationFiled: March 1, 2016Publication date: November 3, 2016Inventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
-
Patent number: 9476834Abstract: A method for preparing a linearly extended supramolecular fiber or a plurality of linearly aligned supramolecular fibers, which comprises the step of allowing supramolecular monomers to be self-assembled in a microfluidic channel.Type: GrantFiled: September 17, 2010Date of Patent: October 25, 2016Assignee: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Shoji Takeuchi, Hiroaki Onoe, Daisuke Kiriya, Itaru Hamachi, Masato Ikeda
-
Patent number: 9327036Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.Type: GrantFiled: April 8, 2010Date of Patent: May 3, 2016Assignee: The Regents of the University of CaliforniaInventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
-
Patent number: 8999443Abstract: A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.Type: GrantFiled: March 27, 2012Date of Patent: April 7, 2015Assignees: NTT DOCOMO, INC., The University of TokyoInventors: Satoshi Hiyama, Kaori Kuribayashi, Hiroaki Onoe, Shoji Takeuchi
-
Patent number: 8785195Abstract: A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.Type: GrantFiled: October 12, 2010Date of Patent: July 22, 2014Assignee: The University of TokyoInventors: Shoji Takeuchi, Hiroaki Onoe, Yukiko Matsunaga, Daisuke Kiriya, Riho Gojo, Midori Negishi
-
Publication number: 20130136863Abstract: A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.Type: ApplicationFiled: March 27, 2012Publication date: May 30, 2013Applicant: NTT DOCOMO, INC.Inventors: Satoshi Hiyama, Kaori Kuribayashi, Hiroaki Onoe, Shoji Takeuchi
-
Publication number: 20130071948Abstract: A method for preparing a linearly extended supramolecular fiber or a plurality of linearly aligned supramolecular fibers, which comprises the step of allowing supramolecular monomers to be self-assembled in a microfluidic channel.Type: ApplicationFiled: September 17, 2010Publication date: March 21, 2013Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCYInventors: Shoji Takeuchi, Hiroaki Onoe, Daisuke Kiriya, Itaru Hamachi, Masato Ikeda
-
Publication number: 20120301963Abstract: A microfiber showing improved mechanical strength, which comprises a micro gel fiber consisting of collagen gel or the like covered with high strength hydrogel such as alginate gel.Type: ApplicationFiled: October 12, 2010Publication date: November 29, 2012Applicant: THE UNIVERSITY OF TOKYOInventors: Shoji Takeuchi, Hiroaki Onoe, Yukiko Matsunaga, Daisuke Kiriya, Riho Gojo, Midori Negishi
-
Publication number: 20120142088Abstract: The present invention provides conjugates of DNA and cells by linking the DNA to a native functional group on the cell surface. The cells can be without cell walls or can have cell walls. The modified cells can be linked to a substrate surface and used in assay or bioreactors.Type: ApplicationFiled: April 8, 2010Publication date: June 7, 2012Applicant: The Regents of the University of CaliforniaInventors: Shih-Chia Hsiao, Matthew B. Francis, Carolyn Bertozzi, Richard Mathies, Ravi Chandra, Erik Douglas, Amy Twite, Nicholas Toriello, Hiroaki Onoe
-
Publication number: 20100279398Abstract: Provided is a technique for handling a minor amount of a biological material with the purpose of observing selectively the interaction between single cells by controlling cell number and two- or three-dimensional configurations of each of the different cell types. The present invention provides an instrument and a method for handling a minor amount of a biological material. The instrument of the present invention for handling a minor amount of a biological material comprises a construct and a base, wherein: the base holds the construct in a releasable manner; the construct is held on a surface of the base in such a manner that a part of the construct is exposed externally on the outer face of the instrument; and at least a part of a surface of the constructs is exposed externally on the outer face of the instrument being fabricated so as to allow the adhesion of the minor amount of the biological material thereto.Type: ApplicationFiled: January 9, 2009Publication date: November 4, 2010Applicant: The University of TokyoInventors: Shoji Takeuchi, Hiroaki Onoe