Abstract: Provided herein are proteins comprising one monovalent human TfR binding domain (“human TfR binding proteins”), proteins comprising one monovalent mouse TfR binding domain (“mouse TfR binding proteins”), conjugates comprising such human or mouse TfR binding proteins, e.g., human TfR binding proteins-dsRNA conjugates, pharmaceutical compositions comprising human TfR binding proteins or conjugates, and methods of treating CNS diseases (e.g., neurodegenerative disease such as neurodegenerative synucleinopathy or tauopathy) using human TfR binding proteins or conjugates.

Abstract: A learning data generation device includes an acquisition unit, an attention level derivation unit, and a selection unit. The acquisition unit acquires sequence data including a plurality of frames that include a target and are consecutive in a sequence. The attention level derivation unit derives an attention level that is feature data in a time axis direction of each of the plurality of frames included in the sequence data by using a trained model. The selection unit selects one or a plurality of frames included in the sequence data as a learning frame to be used for learning data based on the attention level.

Abstract: A collision possibility determination device includes: a detection unit which detects at least one object which moves relatively with respect to a moving body; and a determination unit which determines a collision possibility of the moving body with the object. The determination unit defines a first factor and a second factor which are spaces between the body and the object in a travelling direction and in a width direction of the body respectively. The determination unit determines the possibility based on the two factors when the object is within a farther area from the body, and the possibility based on only the first factor when the object is within a nearer area from the body.

Abstract: A collision possibility determination device includes: a detection unit which detects at least one object which moves relatively with respect to a moving body; and a determination unit which determines a collision possibility of the moving body with the object. The determination unit defines a first factor and a second factor which are spaces between the body and the object in a travelling direction and in a width direction of the body respectively. The determination unit determines the possibility based on the two factors when the object is within a farther area from the body, and the possibility based on only the first factor when the object is within a nearer area from the body.

Abstract: A roadside object present at the side of a subject vehicle travel path and a preceding vehicle at a speed equal to or greater than a predetermined speed are detected based on points derived by transmitting an electromagnetic beam forward of the subject vehicle and projecting reflection points obtained onto a two-dimensional plane, a determination is made when the preceding vehicle passes near the roadside object as to whether it moved toward the travel path within a predetermined time before and after the passage, and the roadside object is not determined to be the obstacle when it is determined to have moved toward the travel path, thereby preventing the roadside object from being misidentified as the obstacle owing to erroneous recognition of it having intruded into the travel path of the subject vehicle when detecting the object using an electromagnetic beam.

Abstract: A roadside object present at the side of a subject vehicle travel path and a preceding vehicle at a speed equal to or greater than a predetermined speed are detected based on points derived by transmitting an electromagnetic beam forward of the subject vehicle and projecting reflection points obtained onto a two-dimensional plane, a determination is made when the preceding vehicle passes near the roadside object as to whether it moved toward the travel path within a predetermined time before and after the passage, and the roadside object is not determined to be the obstacle when it is determined to have moved toward the travel path, thereby preventing the roadside object from being misidentified as the obstacle owing to erroneous recognition of it having intruded into the travel path of the subject vehicle when detecting the object using an electromagnetic beam.

Abstract: The object-detection device for vehicle provides a transmission-and-reception device; a reflection point calculation device; a segment setting device; a median point calculation device; and a relative speed calculation device, wherein the relative speed calculation device eliminates a calculation result of the relative speed in the car width direction, with respect to the reflection points calculated based on the electromagnetic waves which are irradiated to the most downward direction in the specified angle in the vertical direction, in case that the number of difference between the reflection points in the current processing and the reflection points in the previous processing is equal to or greater than a predetermined number.

Abstract: The object-detection device for vehicle provides a transmission-and-reception device; a reflection point calculation device; a segment setting device; a median point calculation device; and a relative speed calculation device, wherein the relative speed calculation device eliminates a calculation result of the relative speed in the car width direction, with respect to the reflection points calculated based on the electromagnetic waves which are irradiated to the most downward direction in the specified angle in the vertical direction, in case that the number of difference between the reflection points in the current processing and the reflection points in the previous processing is equal to or greater than a predetermined number.

Abstract: This invention is in the fields of medicine and neurology, and relates to methods and agents for early diagnosis and monitoring of Alzheimer's disease and other neurological disorders. More particularly, the present invention provides the method for evaluating the health of central nervous system neurons in a human patient, comprising the steps of: a) administering to said patient a population of molecular complexes comprising (i) a polypeptide capable of activating neuronal endocytosis, axonal transport, and synaptic transfer; and (ii) an imaging agent suited for determining location and evaluating neuronal transport of said molecular complexes within said patient; and b) using at least one imaging method to determine location and evaluate neuronal transport of said molecular complexes within said patient.

Abstract: A DLL circuit includes a phase comparator configured to compare timing between a first clock signal and a second clock signal, a delay circuit configured to delay the first clock signal for output as the second clock signal by a delay length responsive to a result of comparison by the phase comparator, and a control circuit configured to suspend supply of the first clock signal to the phase comparator temporarily while the second clock signal is supplied to the phase comparator.

Abstract: In vivo screening is used to identify and isolate ligands that drive endocytosis (internalisation) of molecules into animal cells. These ligands can transport passenger molecules (drug or diagnostic compounds, genetic vectors, etc.) into targeted classes of cells. A population of candidate ligands, such as a phage display or combinatorial library, is placed in a rat leg, in contact with a sciatic nerve bundle, and a ligature is tightened around the same nerve bundle at the hip. After a delay, to enable ligands that bind to endocytotic receptors on the nerve fibers to be internalised and transported within the fibers, fiber segments are harvested from the ligature site in the hip. Ligands that entered the harvested nerve segments can be isolated, sequenced, reproduced, etc. If desired, rats can be transformed to express human endocytotic receptors, to allow selection of ligands that will be transported into targeted human cells.

Abstract: A DLL circuit includes a phase comparator configured to compare timing between a first clock signal and a second clock signal, a delay circuit configured to delay the first clock signal for output as the second clock signal by a delay length responsive to a result of comparison by the phase comparator, and a control circuit configured to suspend supply of the first clock signal to the phase comparator temporarily while the second clock signal is supplied to the phase comparator.

Abstract: A voltage controlled oscillation circuit with an oscillation frequency thereof controlled in accordance with an external voltage is disclosed. An odd number of inversion circuit elements such as inverters for inverting output signals thereof with respect to input signals thereto are connected in series with each other. An output side of the last-stage one of the odd number of the inversion circuit elements is connected to an input side of the first-stage one of the inversion circuit elements to thereby cause an oscillation. A plurality of oscillation frequency variable control units such as variable resistor circuit elements for changing an oscillation frequency in accordance with an external voltage are each inserted between each set of adjacent inversion circuit elements. A plurality of fixed resistor circuit elements each having a fixed resistance value are connected in parallel with a plurality of the oscillation frequency variable control units, respectively.

Abstract: In a radio paging receiver, a CPU selects (SA3) from call signals a specific call signal specific to the receiver and from message signals a specific message signal that follows the specific call signal and represents a specific message, which is displayed (SA23) on a display. The CPU judges (SA20) whether or not the specific message is identical with a predetermined message. An EEPROM memorizes (SA21) an inhibit signal when the specific message is identical with the predetermined message. The CPU puts (SA23-SA25) the receiver out of operation when the EEPROM memorizes the inhibit signal. The CPU makes (SA23) the display display the predetermined message when the EEPROM memorizes the inhibit signal.