Abstract: A method for producing a first vadadustat intermediate represented by the following formula (3) comprising reacting a compound represented by the following formula (1) with glycine or a glycine derivative represented by the following formula (2) or a salt of the glycine or the glycine derivative in the presence of carbon monoxide. The method produces a vadadustat intermediate through a clean reaction with high atom conversion efficiency.

Abstract: A method for producing a (2-methylpyrimidin-5-yl)boronic acid derivative (3) includes the step of decarboxylating a 5-bromopyrimidine derivative (1) to synthesize 5-bromo-2-methylpyrimidine (2). The method enables efficient production of 5-bromo-2-methylpyrimidine (2) with less environmental impact, leading to efficient production of (2-methylpyrimidin-5-yl)boronic acid derivative (3) which is useful as a pharmaceutical intermediate.

Abstract: A method for producing a first vadadustat intermediate represented by the following formula (3) comprising reacting a compound represented by the following formula (1) with glycine or a glycine derivative represented by the following formula (2) or a salt of the glycine or the glycine derivative in the presence of carbon monoxide. The method produces a vadadustat intermediate through a clean reaction with high atom conversion efficiency.

Abstract: An object is to provide a novel flow reactor capable of measuring the internal temperature. The flow reactor including a tubular reaction line, wherein the flow reactor further includes an internal temperature measurement unit provided at one or more location of the tubular reaction line, the internal temperature measurement unit includes a thermometer with a temperature sensor, and the temperature sensor is inserted into the tubular reaction line.

Abstract: An object of the present invention is to provide a method for producing an immobilized microorganism having high filtration properties, and to provide a method for producing an amino acid using the immobilized microorganism. A method for producing an immobilized microorganism is characterized in that a microorganism is contacted with carboxymethyl cellulose sodium salt and then contacted with polyethylenimine and an alkane dial after the first contact with carboxymethyl cellulose sodium salt.

Abstract: A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.

Abstract: The purpose of the present invention is to provide a flow reactor that can ensure safety even if leakage occurs at the connections of the lines. The flow reactor of the present invention is characterized by including one or more line structures, each of the line structures including a raw material feeding line, a reactor unit to react a raw material fed from the raw material feeding line, and a discharge line to discharge a reaction product produced in the reactor unit, wherein the flow reactor includes a vessel in which part or all of the reactor unit and a fluid are accommodated to be capable of being in contact with each other, wherein each of the line structures includes two or more attachable and detachable connections, and wherein at least one of the attachable and detachable connections is accommodated in the vessel.

Abstract: A high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.

Abstract: An object is to provide a novel flow reactor capable of measuring the internal temperature. The flow reactor including a tubular reaction line, wherein the flow reactor further includes an internal temperature measurement unit provided at one or more location of the tubular reaction line, the internal temperature measurement unit includes a thermometer with a temperature sensor, and the temperature sensor is inserted into the tubular reaction line.

Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.

Abstract: A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.

Abstract: The purpose of the present invention is to provide a flow reactor that can ensure safety even if leakage occurs at the connections of the lines. The flow reactor of the present invention is characterized by including one or more line structures, each of the line structures including a raw material feeding line, a reactor unit to react a raw material fed from the raw material feeding line, and a discharge line to discharge a reaction product produced in the reactor unit, wherein the flow reactor includes a vessel in which part or all of the reactor unit and a fluid are accommodated to be capable of being in contact with each other, wherein each of the line structures includes two or more attachable and detachable connections, and wherein at least one of the attachable and detachable connections is accommodated in the vessel.

Abstract: A high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.

Abstract: The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound.

Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.

Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.

Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.