Patents by Inventor Hiroaki Yasukouchi

Hiroaki Yasukouchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10781193
    Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.
    Type: Grant
    Filed: January 10, 2019
    Date of Patent: September 22, 2020
    Assignee: KANEKA CORPORATION
    Inventors: Hiroaki Yasukouchi, Masaru Mitsuda, Akira Nishiyama, Makoto Funabashi
  • Publication number: 20200207717
    Abstract: A process for producing an organic compound using a flow reactor for a first reaction in which a raw material liquid A and a raw material liquid B are mixed, and reacted in a reactor unit, and a flow reactor for a second reaction in which a first reaction solution discharged from the flow reactor for the first reaction and a raw material liquid C are mixed, and reacted in a reactor unit, wherein the raw material liquid A is a solution in which triphosgene and/or diphosgene is dissolved, wherein the raw material liquid B is a nitrogen-containing organic compound or a solution thereof, wherein the raw material liquid C is a reaction substrate having a functional group capable of reacting with phosgene, or a solution containing the reaction substrate, and wherein a product of the first reaction is phosgene.
    Type: Application
    Filed: March 5, 2020
    Publication date: July 2, 2020
    Applicant: KANEKA CORPORATION
    Inventors: Hiroaki Yasukouchi, Akira Nishiyama, Koji Machida
  • Publication number: 20200139339
    Abstract: The purpose of the present invention is to provide a flow reactor that can ensure safety even if leakage occurs at the connections of the lines. The flow reactor of the present invention is characterized by including one or more line structures, each of the line structures including a raw material feeding line, a reactor unit to react a raw material fed from the raw material feeding line, and a discharge line to discharge a reaction product produced in the reactor unit, wherein the flow reactor includes a vessel in which part or all of the reactor unit and a fluid are accommodated to be capable of being in contact with each other, wherein each of the line structures includes two or more attachable and detachable connections, and wherein at least one of the attachable and detachable connections is accommodated in the vessel.
    Type: Application
    Filed: January 7, 2020
    Publication date: May 7, 2020
    Applicant: KANEKA CORPORATION
    Inventors: Shiori Ozasa, Takahiro Ohishi, Hiroaki Yasukouchi
  • Publication number: 20190300465
    Abstract: A high-purity alcohol compound can be obtained by a method comprising passing a solution containing an ester compound and methanol and/or ethanol through a column packed with an anion exchange resin having methoxide and/or ethoxide as a counter anion to generate a methyl ester and/or ethyl ester, and distilling off the methyl ester and/or ethyl ester together with the methanol and/or ethanol.
    Type: Application
    Filed: June 19, 2019
    Publication date: October 3, 2019
    Applicant: KANEKA CORPORATION
    Inventors: Koji MACHIDA, Hiroaki Yasukouchi, Akira Nishiyama
  • Publication number: 20190177262
    Abstract: The present invention provides a method for safely producing a large amount of chloroformate compound with high yield. The chloroformate compound can be produced by mixing and reacting a solution of triphosgene, an amine and an alcohol compound in a flow reactor. The chloroformate compound can also be produced by mixing and reacting a solution of triphosgene with a solution comprising an amine and an alcohol compound in a flow reactor. The amine is preferably tributylamine, and preferably used in an amount of 0.8 to 3 equivalents relative to an amount of the alcohol compound.
    Type: Application
    Filed: January 10, 2019
    Publication date: June 13, 2019
    Applicant: KANEKA CORPORATION
    Inventors: Hiroaki YASUKOUCHI, Makoto FUNABASHI, Akira NISHIYAMA, Toshihiro TAKEDA, Masaru MITSUDA
  • Publication number: 20190144404
    Abstract: The present disclosure provides a reaction of a chlorine-containing compound using a flow reactor which is less restricted by a solvent to be used. In the present disclosure, an organic compound is produced by supplying a reaction substrate having at least one functional group which can react with chlorine and is selected from the group consisting of hydroxy group, a thiol group, an amino group, a carboxyl group, a thiocarboxyl group, and an acid amide group, and a chlorine-containing compound to a flow reactor together with a trialkyl amine having 9 to 40 carbon atoms and an organic solvent, and allowing the reaction substrate and the chlorine-containing compound to react with each other.
    Type: Application
    Filed: January 10, 2019
    Publication date: May 16, 2019
    Applicant: KANEKA CORPORATION
    Inventors: Hiroaki YASUKOUCHI, Masaru MITSUDA, Akira NISHIYAMA, Makoto FUNABASHI
  • Patent number: 8183413
    Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.
    Type: Grant
    Filed: January 16, 2007
    Date of Patent: May 22, 2012
    Assignee: Kaneka Corporation
    Inventors: Narumi Kishimoto, Hiroaki Yasukouchi, Toshihiro Takeda
  • Publication number: 20090312577
    Abstract: Provided is a process for production of a ?-amino-?-hydroxy carboxamide derivative that is important in production of drugs or the like. In the presence of a predetermined solvent, a ?-(N-protected)amino-?-hydroxycarboxylic acid is reacted with an amine to conversion to a ?-(N-protected)amino-?-hydroxy carboxamide derivative; then the derivative is deprotected for conversion to a ?-amino-?-hydroxy carboxamide derivative; and the derivative is crystallized using a protic solvent to obtain a crystal. The high-purity ?-amino-?-hydroxy carboxamide derivative can be stably produced on an industrial scale by the process.
    Type: Application
    Filed: January 16, 2007
    Publication date: December 17, 2009
    Inventors: Narumi Kishimoto, Hiroaki Yasukouchi, Toshihiro Takeda