Patents by Inventor Hirofumi Doi

Hirofumi Doi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190186104
    Abstract: An operational data storage device mounted on an hydraulic excavator is programmed to store operational data including stroke data and movement quantity data. The stroke data represent input operations by the operator of the hydraulic excavator through electric operating levers, and the movement quantity data represent movement quantities of operating members for a front working device equipped with the hydraulic excavator, the operating member being operated according to the input operations. The operational data storage device stores, in an initial state, the operational data in the volatile storage section, generates a save and exit signal if a posture parameter detected at a posture detection sensor included in the hydraulic excavator exceeds a predetermined posture threshold, and responsive to the save and exit signal, switches a write destination of the operational data from the volatile storage section to the non-volatile storage section.
    Type: Application
    Filed: February 13, 2018
    Publication date: June 20, 2019
    Inventors: Takeshi SHIINA, Hiroshi KANEZAWA, Hirofumi MIGITA, Shintaro DOI, Toshiakira TAKAHASHI, Masatoshi SAKURAI, Yoshitaka YANASE, Akiko MAENO
  • Patent number: 9670255
    Abstract: It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: June 6, 2017
    Assignee: SAVID THERAPEUTICS INC.
    Inventors: Akira Sugiyama, Hirofumi Doi, Tatsuhiko Kodama, Tsuyoshi Inoue, Eiichi Mizohata, Tatsuya Kawato, Tomohiro Meshizuka, Motomu Kanai, Yohei Shimizu, Tomohiro Yamamoto
  • Publication number: 20170145063
    Abstract: An object of this invention is to provide a streptavidin mutant reduced in affinity to the naturally-occurring biotin, and to provide a modified biotin which shows a high affinity to such streptavidin mutant reduced in affinity to the naturally-occurring biotin. This invention can provide a compound composed of a dimer of modified biotin, a streptavidin mutant, and usage of them.
    Type: Application
    Filed: February 18, 2015
    Publication date: May 25, 2017
    Applicant: SAVID THERAPEUTICS INC.
    Inventors: Akira SUGIYAMA, Hirofumi DOI, Tatsuhiko KODAMA, Tsuyoshi INOUE, Eiichi MIZOHATA, Tatsuya KAWATO, Tomohiro MESHIZUKA, Motomu KANAI, Yohei SHIMIZU, Noriaki TAKASU, Mari TAKATSU
  • Publication number: 20160226355
    Abstract: A first stator core and a second stator core are configured by arranging pairs of core blocks into an annular shape, the pairs of core blocks being configured by stacking together core blocks so as to be spaced apart axially, the core blocks including circular arc-shaped core back portions and teeth, permanent magnets are each configured so as to be divided into a plurality of magnet blocks that are held between the pairs of core blocks so as to fit inside the pairs of core blocks, and the magnet blocks include a base portion that is held between the core back portions, and that has an external shape in which two circumferential side surfaces are positioned circumferentially inside two circumferential side surfaces of the core back portions.
    Type: Application
    Filed: June 18, 2014
    Publication date: August 4, 2016
    Applicant: MITSUBISHI ELECTRIC CORPORATION
    Inventors: Hideaki ARITA, Akihiro DAIKOKU, Hirofumi DOI
  • Publication number: 20160137704
    Abstract: It is an object of the present invention to provide a mutant streptavidin with a reduced affinity for natural biotin, and also to provide a modified biotin having a high affinity for the mutant streptavidin with a reduced affinity for natural biotin. According to the present invention, there is provided a reagent kit for use in treatments or diagnoses, which comprises: (a) a mutant streptavidin with a reduced affinity for natural biotin or biocytin; and a modified biotin having a high affinity for the above-described mutant streptavidin.
    Type: Application
    Filed: February 18, 2014
    Publication date: May 19, 2016
    Applicant: SAVID THERAPEUTICS INC.
    Inventors: Akira SUGIYAMA, Hirofumi DOI, Tatsuhiko KODAMA, Tsuyoshi INOUE, Eiichi MIZOHATA, Tatsuya KAWATO, Tomohiro MESHIZUKA, Motomu KANAI, Yohei SHIMIZU, Tomohiro YAMAMOTO
  • Patent number: 9051610
    Abstract: A method for identifying the presence of a target gene mRNA is provided, which involves hybridizing one or more oligonucleic acid probes with the target gene mRNA expressed in a tissue sample, and detecting a low-molecular-weight compound label added to at least one of the bases of the oligonucleic acid probes. The oligonucleic acid probes are contacted with the tissue sample for hybridization with the target gene mRNA after pretreating (prehybridizing) one or more dummy oligonucleic acids with the tissue sample, or a mixture of the oligonucleic acid probes and the dummy oligonucleic acids is contacted with the sample tissue to hybridize the oligonucleic acid probes with the target gene mRNA.
    Type: Grant
    Filed: May 19, 2009
    Date of Patent: June 9, 2015
    Assignee: CELISH FD, INC.
    Inventors: Hirofumi Doi, Masahiro Matsuoka, Tatsuhiro Nakano, Chizuru Nagayoshi
  • Patent number: 8546537
    Abstract: It is an object of the present invention to provide a mutant streptavidin wherein the immunogenicity (antigenicity) in mammals of a streptavidin is reduced. The present invention provides a mutant streptavidin, which comprises an amino acid sequence in which (a) the arginine residue at position 72 is substituted with another amino acid residue, and (b) any one or more of the tyrosine residue at position 10, the tyrosine residue at position 71, the glutamic acid residue at position 89, the arginine residue at position 91, and the glutamic acid residue at position 104 are substituted with other amino acid residues, with respect to the amino acid sequence of a core streptavidin as shown in SEQ ID NO: 2, and which has decreased immunogenicity as compared with that of a wild-type streptavidin.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: October 1, 2013
    Assignees: The University of Tokyo, Perseus Proteomics Inc.
    Inventors: Tatsuhiko Kodama, Takao Hamakubo, Hirofumi Doi, Akira Sugiyama, Kouhei Tsumoto
  • Publication number: 20120039879
    Abstract: It is an object of the present invention to provide a mutant streptavidin wherein the immunogenicity (antigenicity) in mammals of a streptavidin is reduced. The present invention provides a mutant streptavidin, which comprises an amino acid sequence in which (a) the arginine residue at position 72 is substituted with another amino acid residue, and (b) any one or more of the tyrosine residue at position 10, the tyrosine residue at position 71, the glutamic acid residue at position 89, the arginine residue at position 91, and the glutamic acid residue at position 104 are substituted with other amino acid residues, with respect to the amino acid sequence of a core streptavidin as shown in SEQ ID NO: 2, and which has decreased immunogenicity as compared with that of a wild-type streptavidin.
    Type: Application
    Filed: February 19, 2010
    Publication date: February 16, 2012
    Applicants: PERSEUS PROTEOMICS INC., THE UNIVERSITY OF TOKYO
    Inventors: Tatsuhiko Kodama, Takao Hamakubo, Hirofumi Doi, Akira Sugiyama, Kouhei Tsumoto
  • Patent number: 8089185
    Abstract: An actuator having an output axis which is moved linearly by a rotatory force, and a boss for holding the above-mentioned output axis in such a way that the output axis can move linearly includes a connecting member for propagating the linear motion of the above-mentioned output axis to an external device. The above-mentioned connecting member is comprised of a joint connected to the above-mentioned output axis, and a link plate having an end rotatably connected to the above-mentioned joint, and another end rotatably connected to the external device. A mechanism for preventing rotation of the above-mentioned output axis is constructed of only a connecting portion for connecting the above-mentioned joint, the above-mentioned link plate, and the above-mentioned external device to one another.
    Type: Grant
    Filed: April 19, 2007
    Date of Patent: January 3, 2012
    Assignee: Mitsubishi Electric Corporation
    Inventors: Kenta Hatano, Hirofumi Doi, Toshihiko Miyake
  • Patent number: 8003346
    Abstract: The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a site which causes, when an N terminal region of the PCNA monomer and a C terminal region of another PCNA monomer act as an interface to form a multimeric complex, an intermolecular interaction of the monomers in an interface region of the monomers.
    Type: Grant
    Filed: July 4, 2006
    Date of Patent: August 23, 2011
    Assignee: Celestar Lexico-Sciences, Inc.
    Inventors: Tadaaki Tokida, Satoshi Hihara, Takashi Kudou, Akira Kawamura, Hirofumi Doi, Yoshizumi Ishino
  • Patent number: 7990001
    Abstract: A terminal structure for a vehicle-mounted motor includes a motor body having a motor terminal 28 connected to a coil, and a circuit body 5 holding a circuit board 18 for controlling a rotation of the motor body and is assembled in the motor body, wherein a stress relaxation section 35 is provided in an intermediate of an intermediate conductor 34, in order to reduce stress acting on the intermediate conductor 34 connecting the motor terminal 28 and the circuit board 18 and to thereby improve the conductive reliability of electrical joint.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: August 2, 2011
    Assignee: Mitsubishi Electric Corporation
    Inventors: Kenta Hatano, Naoki Miyamoto, Toshiyuki Umemoto, Hirofumi Doi
  • Publication number: 20110183331
    Abstract: Disclosed is a method for identifying the presence of a target gene mRNA, which comprises hybridizing one or more oligonucleic acid probes with the target gene mRNA expressed in a tissue sample, and detecting a low-molecular-weight compound label added to at least one of the bases of the oligonucleic acid probes, wherein the oligonucleic acid probes are contacted with the tissue sample for hybridization with the target gene mRNA after pretreating (prehybridizing) one or more dummy oligonucleic acids with the tissue sample, or a mixture of the oligonucleic acid probes and the dummy oligonucleic acids is contacted with the sample tissue to hybridize the oligonucleic acid probes with the target gene mRNA, and wherein the dummy oligonucleic acids are substantially equal in length with the oligonucleic acid probes, and are neither hybridizable with regions of the target gene mRNA with which the oligonucleic acid probes hybridize nor with the oligonucleic acid probes.
    Type: Application
    Filed: May 19, 2009
    Publication date: July 28, 2011
    Applicant: Celish FD, INC.
    Inventors: Hirofumi Doi, Masahiro Matsuoka, Tatsuhiro Nakano, Chizuru Nagayoshi
  • Patent number: 7820423
    Abstract: The present application provides a method for predicting the functional site of a protein using data of the entire proteins of an organism of which genome data or cDNA data is known. More specifically, the present application provides a method for predicting a protein functional site, comprising the steps of calculating the frequency of occurrence of an oligopeptide in the entire proteins, calculating the value of each amino-acid residue contributing to the frequency of occurrence as the representative value of the function, and predicting the protein functional site by using the representative value of function as an indicator. The present also provides a system for predicting a functional site for automatically performing said methods.
    Type: Grant
    Filed: May 31, 2007
    Date of Patent: October 26, 2010
    Assignee: Japan Science And Technology Corporation
    Inventors: Hirofumi Doi, Hideaki Hiraki, Akio Kanai
  • Publication number: 20100231070
    Abstract: An actuator having an output axis which is moved linearly by a rotatory force, and a boss for holding the above-mentioned output axis in such a way that the output axis can move linearly includes a connecting member for propagating the linear motion of the above-mentioned output axis to an external device. The above-mentioned connecting member is comprised of a joint connected to the above-mentioned output axis, and a link plate having an end rotatably connected to the above-mentioned joint, and another end rotatably connected to the external device. A mechanism for preventing rotation of the above-mentioned output axis is constructed of only a connecting portion for connecting the above-mentioned joint, the above-mentioned link plate, and the above-mentioned external device to one another.
    Type: Application
    Filed: April 19, 2007
    Publication date: September 16, 2010
    Inventors: Kenta Hatano, Hirofumi Doi, Toshihiko Miyake
  • Publication number: 20100230907
    Abstract: An actuator equipped with a boot for preventing an intruder from intruding into the actuator by way of an output axis's surface includes a plate formed in a cylindrical shape, having an end in which a flange to which an end portion of the above-mentioned boot is locked is formed and being fitted to the above-mentioned output axis, and a projection formed on an outer surface of the above-mentioned output axis in such away as to lock the above-mentioned plate. A breathing hole for communicating the interior of the above-mentioned boot with the exterior of the above-mentioned boot is disposed between the above-mentioned output axis and the above-mentioned plate.
    Type: Application
    Filed: April 19, 2007
    Publication date: September 16, 2010
    Inventors: Kenta Hatano, Hirofumi Doi, Toshihiko Miyake
  • Publication number: 20100071435
    Abstract: A method of producing a heat shield includes the step of producing a plate-shaped material provided by developing a funnel shape having a plurality of face sections (20, 21, 22) which are adjacent to each other and one (20) of which is a mounting surface and the bending step of bending the plate-shaped material such that the face sections (21, 22) other than the face section (20) corresponding to the mounting surface are orthogonal to the mounting surface section.
    Type: Application
    Filed: December 26, 2007
    Publication date: March 25, 2010
    Inventors: Kenta Hatano, Toshiyuki Umemoto, Hirofumi Doi
  • Publication number: 20100007228
    Abstract: A terminal structure for a vehicle-mounted motor includes a motor body having a motor terminal 28 connected to a coil, and a circuit body 5 holding a circuit board 18 for controlling a rotation of the motor body and is assembled in the motor body, wherein a stress relaxation section 35 is provided in an intermediate of an intermediate conductor 34, in order to reduce stress acting on the intermediate conductor 34 connecting the motor terminal 28 and the circuit board 18 and to thereby improve the conductive reliability of electrical joint.
    Type: Application
    Filed: October 30, 2007
    Publication date: January 14, 2010
    Inventors: Kenta Hatano, Naoki Miyamoto, Toshiyuki Umemoto, Hirofumi Doi
  • Publication number: 20090209003
    Abstract: The present invention is to construct a DNA replication reaction system which is excellent in versatility and is easily used. An amino acid sequence of a PCNA monomer which is one of factors involved in DNA replication is prepared so that amino acid residues causing mutual charge repulsion constitute a site which causes, when an N terminal region of the PCNA monomer and a C terminal region of another PCNA monomer act as an interface to form a multimeric complex, an intermolecular interaction of the monomers in an interface region of the monomers.
    Type: Application
    Filed: July 4, 2006
    Publication date: August 20, 2009
    Inventors: Tadaaki Tokida, Satoshi Hihara, Takashi Kudou, Akira Kawamura, Hirofumi Doi, Yoshizumi Ishino
  • Publication number: 20080262201
    Abstract: The present application provides a method for predicting the functional site of a protein using data of the entire proteins of an organism of which genome data or cDNA data is known. More specifically, the present application provides a method for predicting a protein functional site, comprising the steps of calculating the frequency of occurrence of an oligopeptide in the entire proteins, calculating the value of each amino-acid residue contributing to the frequency of occurrence as the representative value of the function, and predicting the protein functional site by using the representative value of function as an indicator. The present also provides a system for predicting a functional site for automatically performing said methods.
    Type: Application
    Filed: May 31, 2007
    Publication date: October 23, 2008
    Inventors: Hirofumi Doi, Hideaki Hiraki, Akio Kanai
  • Publication number: 20080004355
    Abstract: A method is described for enhancing degradation of telomerase. This method includes inhibiting the binding of TERT (telomerase catalytic subunit) to USP21, the binding of NEDD8-conjugated TERT to USP21, or the NEDD8 deconjugation by USP21 from NEDD8-conjugated TERT. A method of inhibiting telomerase activity is also described. The method includes utilizing the method of enhancing the degradation. A method of identifying a compound that inhibits the binding or the NEDD8 deconjugation is further described. An agent for inhibiting telomerase activity is described. An agent for preventing and/or treating diseases attributable to the enhanced telomerase activity is described and includes an inhibitory agent. Also, a method of preventing and/or treating diseases is described and includes using the inhibition method or the inhibitory agent. Further, a reagent kit is described.
    Type: Application
    Filed: December 27, 2005
    Publication date: January 3, 2008
    Inventors: Naoya Wada, Takashi Okamoto, Keiji Tanigaki, Hirofumi Doi, Kensaku Imai