Patents by Inventor Hirofumi HAKUBA

Hirofumi HAKUBA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230158483
    Abstract: An object of the present invention is to provide an ion-exchange membrane for simply and inexpensively separating and purifying exosomes present in a biological sample such as serum. The invention relates to a cellulose-based ion-exchange membrane containing a cellulose-based polymer having at least one hydroxyl group or acetyl group at the 2-, 3-, or 6-position being replaced with a positively charged compound. The invention also relates to a method for purifying exosomes, including subjecting a sample containing exosomes to membrane permeation by using the cellulose-based ion-exchange membrane to allow for adsorption of the exosomes, bringing the membrane into contact with a washing liquid to remove impurities, and bringing the membrane into contact with an eluent to allow for desorption of the exosomes.
    Type: Application
    Filed: April 23, 2021
    Publication date: May 25, 2023
    Applicant: TOYOBO CO., LTD.
    Inventors: Ayano Higaki, Hirofumi Hakuba
  • Publication number: 20220030861
    Abstract: The objective of the present invention is to provide a material to inhibit and/or remove a formation of a biofilm which material can be dispersed in water, of which effect can be sustained even in an environment such as water section, and which is highly safe and environmentally friendly. [Solution] The present invention relates to a fine particle comprising a complex consisting of a polycarboxylic acid derivative and a drug, wherein the fine particle is water-dispersible.
    Type: Application
    Filed: September 20, 2019
    Publication date: February 3, 2022
    Applicant: TOYOBO CO., LTD.
    Inventor: Hirofumi HAKUBA