Abstract: An objective of the present disclosure is to provide: anticancer agents having an immune cell-activating effect, a cytotoxic activity, or an antitumor activity, but having a low effect on non-tumor tissues such as normal tissues and having few side effects; combination therapies using those anticancer agents and other anticancer agents; and pharmaceutical combinations for use in those combination therapies. Anticancer agents expected to be applied to various types of cancers, which have an immune cell-activating effect, a cytotoxic activity, or an antitumor activity while having a low effect on non-tumor tissues such as normal tissues and having few side effects by using as an active ingredient an anti-CD137 antigen-binding molecule of the present disclosure, the binding activity of which to CD137 changes depending on various substances (for example, low molecular weight compounds) in target tissues, are provided.

Abstract: A carbonaceous refractory material is produced by adding an organic binder to a mixture containing a carbonaceous material comprising a carbonaceous raw material comprising calcined anthracite, calcined coke, artificial graphite or natural graphite or a mixture thereof at 50 to 85% as the principal raw material, alumina particle at 5 to 15%, metal silicon particle at 5 to 15%, and one or two or more of titanium carbide powder, titanium nitride powder and titanium carbonitride powder at 5 to 20% in total, kneading and molding the resulting mixture and baking the molded article under non-oxidizing atmosphere. By using the carbonaceous refractory material as the inner lining material for the side wall and bottom of blast furnace hearth, the consumption of the inner lining material due to the dissolution thereof in melted pig iron can be decreased, and simultaneously, the abrasion due to the flow of melted pig iron can be decreased, which works to prolong the life of the blast furnace.

Abstract: A carbonaceous refractory material is produced by adding an organic binder to a mixture containing a carbonaceous material comprising a carbonaceous raw material comprising calcined anthracite, calcined coke, artificial graphite or natural graphite or a mixture thereof at 50 to 85% as the principal raw material, alumina particle at 5 to 15%, metal silicon particle at 5 to 15%, and one or two or more of titanium carbide powder, titanium nitride powder and titanium carbonitride powder at 5 to 20% in total, kneading and molding the resulting mixture and baking the molded article under non-oxidizing atmosphere. By using the carbonaceous refractory material as the inner lining material for the side wall and bottom of blast furnace hearth, the consumption of the inner lining material due to the dissolution thereof in melted pig iron can be decreased, and simultaneously, the abrasion due to the flow of melted pig iron can be decreased, which works to prolong the life of the blast furnace.

Abstract: It is an object of the present invention to realize a PHS terminal disabling system which can improve the recovery rate of lent PHS terminals. The PHS terminal disabling system includes a PHS terminal, a plurality of cell sites for communicating with the PHS terminal, and an exchange for performing an exchanging operation of the PHS terminal via the cell sites.