Patents by Inventor Hirofumi Okoshi

Hirofumi Okoshi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Liposomal trimethylsphingosine
    Patent number: 5466716
    Abstract: Liposomal N,N,N-Trimethylsphingosine and pharmaceutical compositions comprising same.
    Type: Grant
    Filed: April 1, 1994
    Date of Patent: November 14, 1995
    Assignee: The Biomembrane Institute
    Inventors: Yasuyuki Igarashi, Mohammad N. Ahmad, Hirofumi Okoshi, Sen-itroh Hakomori
  • Effect of N,N,N-trimethylsphingosine on protein kinase-C activity; melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
    Patent number: 5331014
    Abstract: The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: July 19, 1994
    Assignee: The Biomembrane Institute
    Inventors: Satoshi Kimura, Yasuyuki Igarashi, Sen-itiroh Hakomori, Mohammad N. Ahmad, Hirofumi Okoshi, Kazuko Handa
  • Method of preparing N,N,N-trimethylsphingosine
    Patent number: 5248824
    Abstract: The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
    Type: Grant
    Filed: May 7, 1992
    Date of Patent: September 28, 1993
    Assignee: The Biomembrane Institute
    Inventors: Yasuyuki Igarashi, Mahammad N. Ahmad, Hirofumi Okoshi, Sen-Itiroh Hakomori
  • Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation
    Patent number: 5137919
    Abstract: The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
    Type: Grant
    Filed: December 31, 1990
    Date of Patent: August 11, 1992
    Assignee: Biomembrane Institute
    Inventors: Yasuyuki Igarashi, Mahammad N. Ahmad, Hirofumi Okoshi, Sen-Itiroh Hakomori