Patents by Inventor Hirofumi Yamano
Hirofumi Yamano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11670398Abstract: It is intended to conveniently determine the pharmacokinetics of axitinib and to predict the therapeutic effect of axitinib. The present invention provides a method for determining the pharmacokinetics of axitinib, comprising the step of calculating a predicted pharmacokinetic parameter of axitinib using specific gene polymorphisms and background factors regarding a test subject.Type: GrantFiled: May 18, 2018Date of Patent: June 6, 2023Assignees: Yamaguchi University, Toyo Kohan Co., Ltd.Inventors: Hideyasu Matsuyama, Yoshihiko Hamamoto, Yusuke Fujita, Yoshiaki Yamamoto, Ryouichi Tsunedomi, Mitsuyoshi Oba, Hirofumi Yamano, Yukiha Ishikawa
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Patent number: 11111526Abstract: In the case of using a blocking nucleic acid to prevent non-specific hybridization of a target nucleic acid with a nucleic acid probe, further excellent efficiency of detecting the target nucleic acid is achieved. A buffer composition used in hybridization of a target nucleic acid with a nucleic acid probe, wherein the buffer composition for hybridization contains a blocking nucleic acid comprising a nucleotide sequence complementary to a region comprising at least a non-detection target nucleotide in a non-target nucleic acid, in a concentration of one or more times higher than the concentration of a nucleic acid in a nucleic acid mixture consisting of the target nucleic acid and the non-target nucleic acid.Type: GrantFiled: August 2, 2017Date of Patent: September 7, 2021Assignees: Toyo Kohan Co., Ltd., Yamaguchi UniversityInventors: Toshiya Tsuda, Shuichi Kamei, Mitsuyoshi Oba, Hirofumi Yamano, Ryouichi Tsunedomi, Shoichi Hazama, Hiroaki Nagano
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Publication number: 20210158893Abstract: It is intended to conveniently determine the pharmacokinetics of axitinib and to predict the therapeutic effect of axitinib. The present invention provides a method for determining the pharmacokinetics of axitinib, comprising the step of calculating a predicted pharmacokinetic parameter of axitinib using specific gene polymorphisms and background factors regarding a test subject.Type: ApplicationFiled: May 18, 2018Publication date: May 27, 2021Applicants: Yamaguchi University, Toyo Kohan Co., Ltd.Inventors: Hideyasu Matsuyama, Yoshihiko Hamamoto, Yusuke Fujita, Yoshiaki Yamamoto, Ryouichi Tsunedomi, Mitsuyoshi Oba, Hirofumi Yamano, Yukiha Ishikawa
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Publication number: 20200190595Abstract: The present invention easily identifies a genotype for gene mutations related to myeloproliferative neoplasms. The present invention comprises a mutant probe that specifically hybridizes with a gene mutation related to myeloproliferative neoplasms in JAK2, a mutant probe that specifically hybridizes with a gene mutation related to myeloproliferative neoplasms in CALR, and a mutant probe that specifically hybridizes with a gene mutation related to myeloproliferative neoplasms in MPL.Type: ApplicationFiled: June 28, 2018Publication date: June 18, 2020Applicants: Toyo Kohan Co., Ltd., Yamaguchi UniversityInventors: Emi Takamitsu, Mitsuyoshi Oba, Junichi Morihiro, Hirofumi Yamano, Toshiaki Yujiri, Masafumi Matsuguma
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Publication number: 20190161791Abstract: In the case of using a blocking nucleic acid to prevent non-specific hybridization of a target nucleic acid with a nucleic acid probe, further excellent efficiency of detecting the target nucleic acid is achieved. A buffer composition used in hybridization of a target nucleic acid with a nucleic acid probe, wherein the buffer composition for hybridization contains a blocking nucleic acid comprising a nucleotide sequence complementary to a region comprising at least a non-detection target nucleotide in a non-target nucleic acid, in a concentration of one or more times higher than the concentration of a nucleic acid in a nucleic acid mixture consisting of the target nucleic acid and the non-target nucleic acid.Type: ApplicationFiled: August 2, 2017Publication date: May 30, 2019Applicants: TOYO KOHAN CO., LTD., YAMAGUCHI UNIVERSITYInventors: Toshiya TSUDA, Shuichi KAMEI, Mitsuyoshi OBA, Hirofumi YAMANO, Ryouichi TSUNEDOMI, Shoichi HAZAMA, Hiroaki NAGANO
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Publication number: 20170253932Abstract: An object of the present invention is to detect a mutation related to BCR-ABL inhibitor resistance with high accuracy for chronic myelogenous leukemia or the like. A method for detecting the mutation comprises the steps of: amplifying a region including a fusion site and a mutation site related to BCR-ABL inhibitor resistance contained in a BCR-ABL fusion gene using a biological sample collected from a subject; and genotyping of the mutation site related to BCR-ABL inhibitor resistance using nucleic acids amplified in the above step.Type: ApplicationFiled: October 16, 2015Publication date: September 7, 2017Applicants: Toyo Kohan Co., Ltd., Yamaguchi UniversityInventors: Mitsuyoshi OBA, Kenichi ABE, Hirofumi YAMANO, Toshiaki YUJIRI
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Patent number: 9050577Abstract: A solid support for maintaining a uniform spot shape while improving the capacity for immobilization of nucleic acids upon spotting of nucleic acids onto a solid support is provided. A substrate has a base material, an electrostatic layer formed on the base material in order to electrostatically attract nucleic acids, and carboxyl groups formed on the electrostatic layer, wherein the ratio, (COO peak intensity)/(C—C peak intensity) in the C1s spectra obtained by X-ray photoelectron spectrometry (XPS) performed for the surface of the substrate ranges from 0.10 to 0.20. The solid support for immobilizing nucleic acids is produced by active esterification of carboxyl groups of the substrate.Type: GrantFiled: September 9, 2010Date of Patent: June 9, 2015Assignee: Toyo Kohan Co., Ltd.Inventor: Hirofumi Yamano
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Patent number: 8778667Abstract: The present invention relates to a unit to be used for detection of interactions of biologically relevant molecules using a carrier on which the biologically relevant molecules are immobilized, comprising: a hollow holder having an open part at one end with the other end being closed; and a carrier-supporting member that can be inserted into the hollow holder, on which is mounted a carrier upon which biologically relevant molecules are immobilized, wherein: while the carrier-supporting member is being inserted into the hollow holder, a rear-end portion of the carrier-supporting member is engaged with an edge of the open part of the hollow holder, so that the hollow holder is sealed and the positions of the carrier-supporting member and the hollow holder are determined; and the area on the left and the area on the right of the axial center, which are defined by the inner side of the hollow holder and the external side of the carrier-supporting member on which the carrier has been mounted, are approximately thType: GrantFiled: May 26, 2009Date of Patent: July 15, 2014Assignee: Toyo Kohan Co., Ltd.Inventors: Hirofumi Yamano, Shuuichi Kamei, Michifumi Tanga
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Patent number: 8563239Abstract: It is intended to provide a solid support capable of immobilizing nucleic acid molecules in a high proportion, and with a high bond strength to nucleic acid molecules. The solid support comprises a substrate and, provided thereon, an electrostatic layer for electrostatically attracting nucleic acid molecules and functional groups capable of covalently binding to nucleic acid molecules.Type: GrantFiled: October 6, 2008Date of Patent: October 22, 2013Assignee: Toyo Kohan Co., Ltd.Inventors: Hiroshi Okamura, Michifumi Tanga, Hirofumi Yamano, Mitsuyoshi Ohba
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Patent number: 8551765Abstract: It is intended to provide a solid support capable of immobilizing nucleic acid molecules in a high proportion, and with a high bond strength to nucleic acid molecules. The solid support comprises a substrate and, provided thereon, an electrostatic layer for electrostatically attracting nucleic acid molecules and functional groups capable of covalently binding to nucleic acid molecules.Type: GrantFiled: July 3, 2003Date of Patent: October 8, 2013Assignee: Toyo Kohan Co., Ltd.Inventors: Hiroshi Okamura, Michifumi Tanga, Hirofumi Yamano, Mitsuyoshi Ohba
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Patent number: 8497068Abstract: A method for detecting hybridization between a probe polynucleotide and a target polynucleotide on a microarray is presented. The method may be used to determine the accuracy of hybridization and possible causes of inaccuracy, such as insufficient washing or deterioration of the microarray.Type: GrantFiled: June 10, 2010Date of Patent: July 30, 2013Assignee: Toyo Kohan Co., Ltd.Inventors: Koichi Hirayama, Hirofumi Yamano, Michifumi Tanga
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Patent number: 8481461Abstract: Described is a means for objectively determining hybridization failure in addition to performance degradation, insufficient washing and the like in a microarray. In particular a method for detecting the hybridization between a probe polynucleotide and a target polynucleotide by using a microarray is presented.Type: GrantFiled: December 13, 2010Date of Patent: July 9, 2013Assignee: Toyo Kohan Co., Ltd.Inventors: Hirofumi Yamano, Koichi Hirayama, Akane Ito
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Publication number: 20120289427Abstract: Described is a means for objectively determining hybridization failure in addition to performance degradation, insufficient washing and the like in a microarray. In particular a method for detecting the hybridization between a probe polynucleotide and a target polynucleotide by using a microarray is presented.Type: ApplicationFiled: December 13, 2010Publication date: November 15, 2012Applicant: TOYO KOHAN CO., LTD.Inventors: Hirofumi Yamano, Koichi Hirayama, Akane Ito
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Publication number: 20120171503Abstract: A solid support for maintaining a uniform spot shape while improving the capacity for immobilization of nucleic acids upon spotting of nucleic acids onto a solid support is provided. A substrate has a base material, an electrostatic layer formed on the base material in order to electrostatically attract nucleic acids, and carboxyl groups formed on the electrostatic layer, wherein the ratio, (COO peak intensity)/(C—C peak intensity) in the C1s spectra obtained by X-ray photoelectron spectrometry (XPS) performed for the surface of the substrate ranges from 0.10 to 0.20. The solid support for immobilizing nucleic acids is produced by active esterification of carboxyl groups of the substrate.Type: ApplicationFiled: September 9, 2010Publication date: July 5, 2012Applicant: Toyo Kohan, Co., Ltd.Inventor: Hirofumi Yamano
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Publication number: 20120088690Abstract: A method for detecting hybridization between a probe polynucleotide and a target polynucleotide on a microarray is presented. The method may be used to determine the accuracy of hybridization and possible causes of inaccuracy, such as insufficient washing or deterioration of the microarray.Type: ApplicationFiled: June 10, 2010Publication date: April 12, 2012Applicant: Toyo Kohan Co., Ltd.Inventors: Koichi Hirayama, Hirofumi Yamano, Michifumi Tanga
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Publication number: 20110111531Abstract: The present invention relates to a unit to be used for detection of interactions of biologically relevant molecules using a carrier on which the biologically relevant molecules are immobilized, comprising: a hollow holder having an open part at one end with the other end being closed; and a carrier-supporting member that can be inserted into the hollow holder, on which is mounted a carrier upon which biologically relevant molecules are immobilized, wherein: while the carrier-supporting member is being inserted into the hollow holder, a rear-end portion of the carrier-supporting member is engaged with an edge of the open part of the hollow holder, so that the hollow holder is sealed and the positions of the carrier-supporting member and the hollow holder are determined; and the area on the left and the area on the right of the axial center, which are defined by the inner side of the hollow holder and the external side of the carrier-supporting member on which the carrier has been mounted, are approximately thType: ApplicationFiled: May 26, 2009Publication date: May 12, 2011Applicant: TOYO KOHAN CO., LTD.Inventors: Hirofumi Yamano, Shuuichi Kamei, Michifumi Tanga
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Publication number: 20100300527Abstract: [Problem] A substrate for a compound semiconductor solar cell which maintains excellent elasticity even after a high temperature process at the time of forming a thin film is provided. [Means for Resolution] The substrate for a compound semiconductor solar cell is formed of a steel plate, and a Cr layer having a coating film quantity of 300 to 8000 mg/m2 is formed on a surface of the substrate on a side to which a solar cell layer is laminated. The Cr layer having a coating film quantity of 500 to 3000 mg/m2 may be formed on the surface of the substrate on a side to which the solar cell layer is laminated, and a film forming temperature of the solar cell layer is less than 550° C. The Cr layer having a coating film quantity of 2000 to 8000 mg/m2 may be formed on the surface of the substrate on a side to which the solar cell layer is laminated, and a film forming temperature of the solar cell layer is more than 800° C.Type: ApplicationFiled: May 28, 2010Publication date: December 2, 2010Applicant: TOYO KOHAN CO., LTD.Inventors: Hiroshi Okamura, Hirofumi Yamano, Masanobu Matsubara, Shigeyoshi Nishiyama
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Publication number: 20090111113Abstract: It is intended to provide a solid support capable of immobilizing nucleic acid molecules in a high proportion, and with a high bond strength to nucleic acid molecules. The solid support comprises a substrate and, provided thereon, an electrostatic layer for electrostatically attracting nucleic acid molecules and functional groups capable of covalently binding to nucleic acid molecules.Type: ApplicationFiled: October 6, 2008Publication date: April 30, 2009Applicant: Toyo Kohan Co. Ltd.Inventors: Hiroshi Okamura, Michifumi Tanga, Hirofumi Yamano, Mitsuyoshi Ohba
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Publication number: 20090098301Abstract: It is intended to provide a solid support capable of immobilizing nucleic acid molecules in a high proportion, and with a high bond strength to nucleic acid molecules. The solid support comprises a substrate and, provided thereon, an electrostatic layer for electrostatically attracting nucleic acid molecules and functional groups capable of covalently binding to nucleic acid molecules.Type: ApplicationFiled: October 6, 2008Publication date: April 16, 2009Applicant: Toyo Kohan Co, Ltd.Inventors: Hiroshi Okamura, Michifumi Tanga, Hirofumi Yamano, Mitsuyoshi Ohba
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Publication number: 20060204959Abstract: It is intended to provide a solid support capable of immobilizing nucleic acid molecules in a high proportion, and with a high bond strength to nucleic acid molecules. The solid support comprises a substrate and, provided thereon, an electrostatic layer for electrostatically attracting nucleic acid molecules and functional groups capable of covalently binding to nucleic acid molecules.Type: ApplicationFiled: July 3, 2003Publication date: September 14, 2006Applicant: Tokyo Kohan Co. Ltd.Inventors: Hiroshi Okamura, Michifumi Tanga, Hirofumi Yamano, Mitsuyoshi Ohba