Patents by Inventor Hiroharu Matsuoka

Hiroharu Matsuoka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methotrexate derivative
    Patent number: 5354753
    Abstract: Disclosed is a compound represented by the formula: ##STR1## wherein R.sup.1 : CH.sub.2, CH.sub.2 CH.sub.2, CH.sub.2 O, CH.sub.2 S, CH.sub.2 SO; R.sup.2 : hydrogen atom, a lower alkyl group having 1 to 4 carbon atoms or a benzyl group; n: an integer of 1 to 4; R.sup.3 : COOR.sup.4, NHCOR.sup.5, CONR.sup.6 R.sup.7, PO.sub.3 H.sub.2, SO.sub.3 H.The compound shows potent antirheumatic function, psoriasis curing function and carcinostatic function and has low toxicity whereby it is available as a medicine.
    Type: Grant
    Filed: February 12, 1993
    Date of Patent: October 11, 1994
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Nobuhiro Ohi, Hiroharu Matsuoka, Katushito Miyamoto, Hiroshi Suzuki, Nobuaki Kato, Keiichiro Tsuji, Yasuhisa Takeda, Masahiko Mihara, Hiromichi Nishina, Shin Shimaoka, Kenichi Akamatsu